ATC Abstracts

American Transplant Congress abstracts

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  • 2013 American Transplant Congress

    Salvage Transplantation Aligns Survival for Small and Large Hepatocellular Carcinomas in the Modern Era of Liver Surgery

    M. Kluger, J. Salceda, A. Laurent, C. Tayar, D. Azoulay, D. Cherqui

    HPB Surgery & Liver Transplantation, NYPH-Weill Cornell Medical Center, New York; Chirurgie Hépatobiliaire, Hôpital Henri Mondor, Créteil, France

    INTRODUCTIONOperative management is standard treatment of hepatocellular carcinoma (HCC). In select patients, resection can offer cure or a bridge to transplantation. This study analyzed resection…
  • 2013 American Transplant Congress

    Divided Daily Prednisolone Dosing Reduces Hyperglycemia after Kidney Transplantation

    S. Cohney, S. Fourlanos, P. Colman, C. Yates

    Medicine, University of Melbourne, Melbourne, Victoria, Australia; Nephrology, Western Hospital, Melbourne, Victoria, Australia; Epidemiology and Preventative Medicine, Monash University, Melbourne, Victoria, Australia; Diabetes and Endocrinology, Royal Melbourne Hospital, Melbourne, Victoria, Australia

    The pharmacokinetics of prednisolone indicate that divided twice daily (BD) dosing would produce more even drug exposure and may improve glycemia compared with daily (QD)…
  • 2013 American Transplant Congress

    Surveillance for Hyperglycemia Post Kidney Transplantation: Afternoon Glucose Superior to Conventional Tests in the First 6 Weeks

    S. Cohney, S. Fourlanos, P. Colman, C. Yates

    Medicine, University of Melbourne, Melbourne, Victoria, Australia; Nephrology, Western Hospital, Melbourne, Victoria, Australia; Epidemiology and Preventative Medicine, Monash University, Melbourne, Victoria, Australia; Diabetes and Endocrinology, Royal Melbourne Hospital, Melbourne, Victoria, Australia

    Optimal screening for hyperglycemia after kidney transplantation remains uncertain. As plasma glucose peaks 7-8 hours after prednisolone administration, fasting plasma glucose (FPG) and oral glucose…
  • 2013 American Transplant Congress

    Clinical Pharmacokinetics of Once-Daily Prolonged-Release Tacrolimus (Graceptor) in De Novo Kidney Transplantation

    Y. Nakagawa, K. Saito, M. Ikeda, M. Tasaki, K. Takahashi

    Division of Urology, Department of Regenerative and Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan

    (Introduction)Graceptor (GCT) is a new formulation of tacrolimus (TRL), allows once-daily administration while showing similar efficacy and safety to the conventional Prograf (PGF), which is…
  • 2013 American Transplant Congress

    Course of BK Virus Infection in Renal Transplant Recipients Treated with Cidofovir

    S. Kuten, S. Patel, R. Knight, L. Gaber, A. Gaber

    The Methodist Hospital, Houston, TX

    In renal transplantation, BK virus may contribute to graft dysfunction and graft loss. While reduction in immunosuppression is considered standard therapy for infection, data has…
  • 2013 American Transplant Congress

    Superior Renal Function Sustained for 24 Months through Early Everolimus-Facilitated Reduction of Tacrolimus Versus Standard Tacrolimus in De Novo Liver Transplant Recipients: Results of a Randomized Trial

    P. De Simone, O. Detry, G. Kintmalm, J. Goss, P. McCormick, M. Rossi, A. Moya, P. Lopez, G. Junge, G. Dong, D. Joseph, C. Duvoux

    For the H2304 Study Group, Pisa, Italy; Novartis Pharma AG, Basel, Switzerland; Novartis Pharmaceuticals Corporation, New Jersey

    mTOR inhibitors have the potential to reduce calcineurin inhibitor nephrotoxicity by minimizing or eliminating the need for their use. The 12 month (M) results of…
  • 2013 American Transplant Congress

    Impact of mTOR and Calcineurin Inhibition on Lipid and Glucose Metabolism – 24 Month Assessment in De Novo Liver Transplant Recipients Treated with Everolimus and Tacrolimus

    L. Fischer, P. De Simone, F. Saliba, J. Fung, G. Dong, P. Lopez, S. Kohler, G. Junge

    For the H2304 Investigators, Hamburg, Germany; Novartis Pharma AG, Basel, Switzerland

    Immunosuppressants, particularly corticosteroids (CS) and calcineurin inhibitors used after liver transplantation (LTx) can adversely affect lipid metabolism. mTOR inhibition blocks insulin-stimulated lipoprotein lipase and can…
  • 2013 American Transplant Congress

    There Is No Difference in Patient Survival after Liver Transplantation between Induction with Rabbit ATG and Basiliximab in Recipients with HCV, However, There Appears To Be Less Severe Fibrosis with rATG

    M. Montenovo, J. Brandenberger, R. Bakthavatsalam, J. Haldorson, A. Dick, J. Perkins, R. Carithers, R. Bhattacharya, L. Yu, I. Liou, C. Landis, M. Yey, J. Reyes, S. Rayhill

    University of Washington, Seattle

    rATG has gained acceptance for induction in liver transplantation. However, due to its strength as an immunosuppressive agent, there is concern that it may be…
  • 2013 American Transplant Congress

    Soluble FGL2 Mediates Acute Rejection in Renal Allograft Recipients by Inducing Tubular Epithelial Cells Apoptosis

    Z. Zhao, C. Yang, L. Wang, L. Li, T. Zhao, D. Wu, R. Rong, M. Xu, T. Zhu

    Zhongshan Hospital, Fudan University, Shanghai, China; Shanghai Key Laboratory of Organ Transplantation, Shanghai, China

    Background: Acute rejection (AR), initiated by infiltrating alloreactive T cells, hampers renal allograft survival. Tubular epithelial cells (TECs) are primary target in AR. TECs apoptosis…
  • 2013 American Transplant Congress

    Effect of Nrf2-keap1 Pathway Activation on Human Pancreatic β Cells, The

    Y. Masuda, S. Li, A. Le, M. Hajighasemi-Ossareh, C. Foster, N. Vaziri, H. Ichii

    Surgery, University of California Irvine, Irvine, CA; Medicine, University of California Irvine, Irvine, CA

    Backgrounds: Islets are known to contain low level of antioxidants which renders them vulnerable to oxidative stress. It is also known that islets are exposed…
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