2013 American Transplant Congress
Liver Grafts from Anti-HBc Positive Donors for Anti-HBc Negative Recipients in Liver Transplantation Using Combined Antiviral Prophylaxis
IntroductionDue to organ shortage the use of so called „marginal livers“ is increasing in deceased donor liver transplantation. Herein we investigate the long term outcome…2013 American Transplant Congress
Regulatory Molecular Profile of Early Ischemia Reperfusion Injury after Liver Transplantation
UVA, Charlottesville; VCU, Richmond
Background: Graft function post liver transplantation (LT) depends on donor quality and the degree of hepatocyte post-ischemia reperfusion injury (IRI). Hereby, we evaluated early-deregulated molecular…2013 American Transplant Congress
Examination of Infectious Complications with Plasmapheresis in Combination with Anti-Thymocycte Globulin for the Treatment of Acute Rejection
Background: Due to the complex nature of acute rejection (AR), multiple therapeutic modalities may be employed. The benefit of plasmapheresis (PP) with anti-thymocyte globulin (ATG)…2013 American Transplant Congress
Potential Contributions to the Direct Pathway by Donor Dendritic Cells at Vascularized Graft
It is widely known that resident dendritic cells (DC) in tissue, or donor DC (dDC), are able to traffic to the secondary lymphoid tissues of…2013 American Transplant Congress
Complement-Activating DSA: Which Assay in Which Setting?
Imperial College Renal & Transplant Centre, Hammersmith Hospital, London, United Kingdom
The presence of pre-formed and de novo donor specific antibodies [DSA] are associated with an increased incidence of antibody mediated rejection [AMR] and graft loss…2013 American Transplant Congress
Regulatory Effect of microRNAs in Ischemia Reperfusion Injury Post Liver Transplantation: Looking for Therapeutic Targets
Background: MicroRNAs (miRNA) exert regulatory effects in biological mechanisms and had been recently targeted for therapeutic interventions. In Liver Transplantation (LT), graft function post reperfusion…2013 American Transplant Congress
Complement-Activating Low-Level Preformed Donor-Specific Antibodies Detected by C1qScreen™ Predict Early Antibody-Mediated Rejection in Renal Allografts
Imperial College Renal & Transplant Centre, Hammermsith Hospital, London, United Kingdom
Renal transplant recipients with negative CDC [CDC-XM] and Flow crossmatch [Flow-XM] and low level DSA [by Luminex] have worse outcomes than non-sensitized patients. The aim…2013 American Transplant Congress
Microvascular Inflammation as a Core Element of Diagnostic Criteria of Antibody-Mediated Rejection (ABMR): C4d Positivity Is Not Reliable Element in Diagnosis of ABMR
Although the current Banff criteria requires positive C4d peritubular capillary (PTC) staining for a definitive diagnosis of ABMR, it has become clear that C4d is…2013 American Transplant Congress
Genomic-Derived Markers for Early Detection of Calcineurin Inhibitor Toxicity Post-Kidney Transplantation: Contribution to Chronic Allograft Dysfunction Progression
UVA, Charlottesville; VCU, Richmond
Background. Use of calcineurin inhibitors (CNIs) after kidney transplantation (KT) induces vasoconstriction of renal afferent arterioles, leading to functional changes and potentially irreversible chronic ischemic…2013 American Transplant Congress
In-Vivo Persistence, Trafficking and Phenotypic Stability of Autologous, Ex-Vivo Expanded Rhesus Macaque Natural Regulatory T Cells
Emory Univ, Atlanta; Univ of Minnesota, Minneapolis
Infusion of ex-vivo expanded natural regulatory T cells (Tregs) is emerging as a promising cellular therapy for the induction of allograft tolerance. However, the lack…
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