ATC Abstracts

American Transplant Congress abstracts

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  • 2013 American Transplant Congress

    Regulatory Effect of microRNAs in Ischemia Reperfusion Injury Post Liver Transplantation: Looking for Therapeutic Targets

    R. Gehrau, V. Mas, C. Dumur, J. Suh, M. Wardus, B. Kane, S. Luebbert, D. Maluf

    Surgery, Division of Transplantation, University of Virginia, Charlottesville, VA; Pathology, VCU, Richmond, VA

    Background: MicroRNAs (miRNA) exert regulatory effects in biological mechanisms and had been recently targeted for therapeutic interventions. In Liver Transplantation (LT), graft function post reperfusion…
  • 2013 American Transplant Congress

    Complement-Activating Low-Level Preformed Donor-Specific Antibodies Detected by C1qScreen™ Predict Early Antibody-Mediated Rejection in Renal Allografts

    C. Lawrence, M. Willicombe, P. Brookes, C. Clarke, E. Santos-Nunez, C. Roufosse, A. Warrens, D. Taube

    Imperial College Renal & Transplant Centre, Hammermsith Hospital, London, United Kingdom

    Renal transplant recipients with negative CDC [CDC-XM] and Flow crossmatch [Flow-XM] and low level DSA [by Luminex] have worse outcomes than non-sensitized patients. The aim…
  • 2013 American Transplant Congress

    Microvascular Inflammation as a Core Element of Diagnostic Criteria of Antibody-Mediated Rejection (ABMR): C4d Positivity Is Not Reliable Element in Diagnosis of ABMR

    K. Sai, K. Omoto, T. Tanabe, H. Shirakawa, M. Setoguchi, T. Shimizu, K. Honda, H. Ishida, K. Tanabe

    Urology, Tokyo Wemen's Medical University, Tokyo, Japan; Hokkaido University, Hokkaido, Japan; Ohkubo Hospital, Tokyo, Japan; Toda Central General Hospital, Saitama, Japan; Pathology, Tokyo Wemen's Medical University, Tokyo, Japan

    Although the current Banff criteria requires positive C4d peritubular capillary (PTC) staining for a definitive diagnosis of ABMR, it has become clear that C4d is…
  • 2013 American Transplant Congress

    Genomic-Derived Markers for Early Detection of Calcineurin Inhibitor Toxicity Post-Kidney Transplantation: Contribution to Chronic Allograft Dysfunction Progression

    V. Mas, J. Suh, R. Gehrau, A. King, K. Brayman, J. Lee, D. Maluf

    UVA, Charlottesville; VCU, Richmond

    Background. Use of calcineurin inhibitors (CNIs) after kidney transplantation (KT) induces vasoconstriction of renal afferent arterioles, leading to functional changes and potentially irreversible chronic ischemic…
  • 2013 American Transplant Congress

    In-Vivo Persistence, Trafficking and Phenotypic Stability of Autologous, Ex-Vivo Expanded Rhesus Macaque Natural Regulatory T Cells

    K. Singh, L. Stempora, A. Garrett, A. Kirk, C. Larsen, B. Blazar, L. Kean

    Emory Univ, Atlanta; Univ of Minnesota, Minneapolis

    Infusion of ex-vivo expanded natural regulatory T cells (Tregs) is emerging as a promising cellular therapy for the induction of allograft tolerance. However, the lack…
  • 2013 American Transplant Congress

    Heparin Induced Thrombocytopenia in Cardiac Transplant Recipients: Incidence and Complications

    Y. Alkhatib, S. Hassan, M. Qayum, U. Qayum, S. Amer, C. Mittal, P. Kuriakose

    Department of Medicine, Henry Ford Hospital, Detroit, MI; Department of Medicine, King Edward Medical University, Lahore, Pakistan

    Background: Heparin induced thrombocytopenia (HIT) is a prothrombotic, complication of heparin therapy, which can lead to serious thromboembolic events and cause significant morbidity and mortality.…
  • 2013 American Transplant Congress

    Non-Alcoholic Fatty Liver Disease (NAFLD) Epidemic and Its Implications for Liver Transplantation

    N. Kemmer, G. Neff, E. Parkinson, E. Cece, A. Alsina

    Tampa General Medical Group, Tampa, FL

    NAFLD is increasingly recognized as the most common chronic liver disease in the western world. With the increasing prevalence of the risk factors of NAFLD…
  • 2013 American Transplant Congress

    Liver Transplantation for Neonatal Hemochromatosis: Analysis of the UNOS Database

    S. Sheflin-Findling, R. Annunziato, R. Ragusa, J. Chu, N. Kerkar, R. Arnon

    Division of Pediatric Hepatology, Mount Sinai Medical Center, New York; Division of Pediatric Gastroenterology, Mount Sinai Medical Center, New York; Psychology Department, Fordham University, Bronx; Recanati/Miller Transplantation Institute, Mount Sinai Medical Center, New York

    Neonatal hemochromatosis (NH) is a rare condition of unclear etiology and remains the most common identifiable cause of acute liver failure in the neonate. Liver…
  • 2013 American Transplant Congress

    Conversion to a Sirolimus-Based Regimen Is Associated with Lower Incidence and Faster Resolution of BK Viremia in Low Risk Kidney Transplant Recipients

    F. Tohme, R. Kalil, C. Thomas

    Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa city, IA

    Background: BK nephropathy is a leading cause of early graft loss in kidney transplant recipients. It is not known if a specific immunosuppressive agent is…
  • 2013 American Transplant Congress

    Acute Kidney Injury in Kidney Transplant Patients According to the Rifle and Akin Criteria

    T. Filiponi, A. Silva-Filho, L. Requião-Moura, E. Tonato, E. Arruda, R. Chinen, L. Mello, A. Bertocci, M. Durão Junior

    Renal Transplantation, Albert Einstein Israelita Hospital, São Paulo, Brazil

    A. PurposeTo assess the incidence, risk factors and outcomes associated with acute kidney injury (AKI) in kidney transplant in-patients using RIFLE (R-risk, I-Injury, F-failure, L-loss,…
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