2013 American Transplant Congress
Novel MyD88 Inhibitor Induced Robust Tolerance in Both Cardiac and Skin Transplantation in Mice, A
Background: Toll-like receptors (TLRs) play essential role in the allograft rejection and tolerance induction. The signal transfer of TLRs, except TLR3, depends either entirely or…2013 American Transplant Congress
Strong Protection Against Renal Ischemia-Reperfusion Injury by MyD88 Inhibitor in Mice
Objectives: TLR signaling plays important role in renal ischemia reperfusion injury (IRI). MyD88 is the key adapter molecule in TLR pathway. This study try to…2013 American Transplant Congress
Determination of Ethyl Glucuronide in Hair for Detection of Alcohol Consumption in Patients after Liver Transplantation
Harmful alcohol consumption after OLT is reported in 11-26% of patients and has a negative impact on long-term outcome. Determination of alcohol marker may help…2013 American Transplant Congress
Cordycepin Inhibits Lipopolysaccharide-Induced Inflammation by the Suppression of the MAPK-IκB-NF-κB Pathways in DCs
Background: Dendritic cells(DCs)are professional APC playing key roles in capturing, processing and presenting antigens as the most potent professional antigen presenting cells. Lipopolysaccharide (LPS) is…2013 American Transplant Congress
Reduction in New Onset Diabetes after Renal Transplant with Erythropoietin Stimulating Agents, a Case Control Study
Background: New-onset diabetes mellitus after transplantation (NODAT) adversely affects graft and patient survival. Approximately 10-15 % of post-renal transplant patients require an erythropoietin stimulating agent…2013 American Transplant Congress
Effect of C1-Esterase Inhibitor (Human) on a Murine Acute Liver Failure Model, The
Univeristy of Massachusetts, Worcester
Acute liver failure (ALF) is associated with a high mortality rate. The incidence of ALF is approximately 2000 cases annually. Drug-related hepatotoxicity accounts for more…2013 American Transplant Congress
Effect of C1-Esterase Inhibitor (Human) on Liver Ischemia-Reperfusion Injury and Regeneration, The
University of Massachusetts Medical School, Worcester
Liver ischemia-reperfusion injury (IRI) is a well-known cause of morbidity and mortality following liver transplantation (LT). Activation of the complement system, especially the lectin pathway,…2013 American Transplant Congress
PROTECT Study: 35 Months of Everolimus Monotherapy vs. Calcineurin Inhibitor-Based Therapy Showed To Be a Safe Alternative with Superior Renal Function in Liver Transplant Recipients, The
Post-transplant immunosuppression with calcineurin inhibitors (CNIs) is associated with impaired renal function. The PROTECT study showed that conversion from CNI to the mTOR-inhibitor everolimus (EVR)…2013 American Transplant Congress
Aggravation of Post-Ischemic Liver Injury by Overexpression of IGFBP-3
Insulin-like growth factor binding protein-3 (IGFBP-3) is known to interfere NF-ΚB signaling pathway in response to a diverse range of stimuli. Liver ischemia/reperfusion injury is…2013 American Transplant Congress
TNF-alpha -238 G-Allele Predisposes to Severe Bacterial Infection in Patients with End-Stage Liver Disease Enlisted for Liver Transplantation, The
Background: Augmented susceptibility to infections increases mortality in patients with end-stage liver disease (ESLD). Activation of pro-inflammatory cytokine production via TLR4, which is a major…
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