2013 American Transplant Congress
Adverse Events of Over-Immunosuppression Are Dependent on Tofacitinib Exposure in Kidney Transplant (KT) Patients
Background: In a prior Phase 2b study in de novo KT pts, a CNI-free tofacitinib fixed-dose regimen achieved comparable rate of biopsy-proven acute rejection (BPAR),…2013 American Transplant Congress
Donor CD4 T Cells Trigger Costimulation Blockade-Resistant Donor Bone Marrow Rejection through Bystander Activation Requiring Interleukin 6
Division of Transplantation, Department of Surgery, Medical University of Vienna, Vienna, Austria
Background:Donor T cells have pleiotropic effects in allogeneic bone marrow transplantation (BMT). Co-transplanting high doses of donor T cells with donor BM causes rejection of…2013 American Transplant Congress
Mycophenolic Acid (MPA) Dosing: Effect on Efficacy to 4 Years after Kidney Transplantation in the Mycophenolic Acid Observational Renal Transplant (MORE) Study
Maintaining adequate MPA dose may be important to optimize efficacy after kidney transplantation, but prospective long-term data are rare.Methods. MORE was a prospective, observational study…2013 American Transplant Congress
Epigenetic Analysis of the TSDR of FOXP3 Demonstrates That Natural Treg Infiltrate the Cardiac Allograft Already before an Acute Rejection Episode
IntroductionTwo subtypes of FOXP3+ regulatory T cells (Treg) have been identified. Natural (n) Treg originate in the thymus, while antigen specific induced (i) Treg are…2013 American Transplant Congress
How To Handle a Missed or Delayed Dose Intake? A Pharmacokinetic Study of Cyclosporine and Tacrolimus in Renal Transplant Patients
BACKGROUND and OBJECTIVES: Despite the efforts made to optimize adherence, every transplant patient will, at least occasionally, miss doses or take them outside the prescribed…2013 American Transplant Congress
Natural History of the Arteriovenous Access and Risk Factors Affecting Spontaneous Closure after Successful Kidney Transplantation, The
Purpose; After successful kidney transplantation (KT), arteriovenous access (AVA) is neither used nor useful. There are many debates whether to preserve an AVA or to…2013 American Transplant Congress
Does African American (AA) Ethnicity Affect Kidney Transplant Outcomes at Four Years? An Analysis of the Mycophenolic Acid Observational Renal Transplant (MORE) Study
Prospective data regarding kidney transplant outcomes in AA kidney transplant patients using modern immunosuppressive regimens are limited.Methods: MORE was a 4-year, prospective, observational study at…2013 American Transplant Congress
Cost of Sepsis in a Program Utilizing Indefinite Sulfamethoxazole-Trimethoprim Prophylaxis in Renal Transplant Recipients
Pharmacy, Barnes-Jewish Hospital, St. Louis, MO; Medicine, Washington University, St. Louis, MO
Background: Sepsis represents a significant cost and disease burden to the renal transplant recipient, adversely impacting both patient and graft survival. Sulfamethoxazole-trimethoprim (SMX-TMP) is a…2013 American Transplant Congress
Outcomes of Transplantation for Uncontrolled HCC and Rescue with Marginal Quality Grafts
Surgery, University of Pennsylvania, Philadelphia, PA
Introduction We examined the survival of patients transplanted for progressive hepatocellular cancer (HCC) not controlled with locoregional therapy (LRT) and the impact of the strategy…2013 American Transplant Congress
Liver Transplantation for Severe Hepatopulmonary Syndrome
Background:Liver transplantation (LT) for hepatopulmonary syndrome (HPS) is well established. However, the outcomes of LT in severe HPS are not widely reported.Methods:Review of a Liver…
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