ATC Abstracts

American Transplant Congress abstracts

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  • 2013 American Transplant Congress

    Alloantigen-Specific Tregs Can Be Identified by Activation-Induced CD154 Expression

    N. Litjens, C. Baan, M. Betjes

    Internal Medicine, Section Nephrology&Transplantation, Erasmus Medical Center, Rotterdam, Netherlands

    IntroductionAntigen (Ag)-specific T cells can be recognized using cell surface expression of markers specifically induced upon T cell receptor interaction with peptides presented in the…
  • 2013 American Transplant Congress

    CD137, a Marker To Detect the Total Alloreactive T Cell Compartment?

    N. Litjens, E. de Wit, C. Baan, M. Betjes

    Internal Medicine, Section Nephrology&Transplantation, Erasmus Medical Center, Rotterdam, Netherlands

    IntroductionAlloreactive T cells are important mediators of rejection or tolerance of the transplanted organ. Detection and isolation of viable alloreactive T cells at the single…
  • 2013 American Transplant Congress

    Agonistic Anti-BTLA mAb (3C10) Induced Prolongation of Murine Cardiac Allograft and Generation of IL-10 Dependent Regulatory CD4+ T Cells, An

    M. Uchiyama, X. Jin, Q. Zhang, L. Yu, H. Bashuda, H. Matsuda, H. Yagita, M. Niimi

    Immunology, Juntendo University Hospital, Tokyo, Japan; Surgery, Harbin Medical University, Harbin, China; Surgery, Teikyo University, Tokyo, Japan

    Background: The co-inhibitory receptor B and T lymphocyte attenuator (BTLA) has been implicated in the regulation of autoimmunity and may potentially play an important role…
  • 2013 American Transplant Congress

    Clinical Outcomes in Sensitized Heart Transplant Patients Bridged with Left Ventricular Assist Devices

    A. Aggarwal, A. Gause, C. Nguyen, I. Balanlayos, G. Bhat

    Center for Heart Transplant and Assist Device, Advocate Christ Medical Center, Oak Lawn, IL

    Background: Patients with pre-transplant left ventricular assist devices (LVAD) develop circulating antibodies with potential donor reactivity after cardiac transplantion. The aim of this study was…
  • 2013 American Transplant Congress

    Effect of Donor Right Hepatectomy on Regeneration of the Liver and the Spleen

    D. Kim, G. Na, T. Hong, Y. Yoo

    Surgery, Seoul St Mary's Hospital, Catholic University of Korea, Seoul, Republic of Korea

    Purpose: Donor hepatectomy for living donor liver transplantation accompanies physiomorphological changes of the liver and the spleen. Therefore, the long-term consequences of these organs should…
  • 2013 American Transplant Congress

    Prospective Surveillance of Kidney Transplant Recipients for BK Viremia Can Reduce or Eliminate BK Virus Associated Nephropathy (BKVAN) Related Graft Loss: Results of a 5-Year Screening Study

    N. Elfadawy, S. Flechner, X. Liu, J. Schold, R. Fatica, T. Srinivas, E. Poggio, R. Avery, S. Mossad

    Glickman Urological and Kidney Institute, Cleveland Clinic Foundation, Cleveland, OH; Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH; Infectious Disease/Medicine Institute, Cleveland Clinic, Cleveland, OH

    Purpose: We aimed to identify the incidence and risk factors for BKVAN as well as measure the impact of immediate therapy on the graft and…
  • 2013 American Transplant Congress

    Effect of Sirtuin 1 Gene Expression on Mouse Islet Graft Survival, The

    Y. Kim, Y. Wee, M. Choi, J. Chang, C. Yun, D. Han

    Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea; Division of Nephrology, Department of Internal Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea; Department of Bioengineering, College of Engineering, Hanyang University, Seoul, Republic of Korea

    Purpose: Islet transplantation is a promising therapy for Type 1 diabetes, however clinical application has not been as successful as organ transplantation due to early…
  • 2013 American Transplant Congress

    Efficacy and Safety of Corticosteroid Withdrawal (CSW) in Kidney Transplant Recipients during Routine Practice: A Prospective, 4-Year Analysis from the Mycophenolic Acid Observational Renal Transplant (MORE) Study

    K. Ueda, A. Wiland, K. McCague, V. Ram Peddi

    California Pacific Medical Center, San Francisco, CA; Novartis Pharmaceuticals Corporation, East Hanover, NJ

    Prospective, long-term data on efficacy and safety outcomes following CSW versus corticosteroid continuation (CSC) in kidney transplant patients during routine clinical practice are largely unavailable.Methods:…
  • 2013 American Transplant Congress

    Efficacy and Safety of 3 vs. 6 Months of Low-Dose Valganciclovir for Prevention of Cytomegalovirus Disease in Moderate-Risk (D+/R+) Renal Transplant Recipients Receiving Antilymphocyte Antibody Induction Therapy

    S. Gabardi, R. Cross, K. DePiero, T. Dick, A. Maldonado, P. Maxwell, J. Nelson, J. Park, K. Ueda, R. Weng, E. Newkirk

    Multicenter CMV Pharmacists Collaborative Study Group, Boston

    The cytomegalovirus (CMV) donor-positive/recipient-positive (D+/R+) population represents the largest group of at-risk renal transplant recipients (RTR). Practice guidelines on the prevention of CMV recommend prophylaxis…
  • 2013 American Transplant Congress

    Intracoronary Treatment with VEGF-C/D Inhibitor Enhances Cardiac Allograft Survival and Prevents Chronic Rejection by Regulating Lymphatic Endothelial Cell Activation

    A. Dashkevich, S. Syrjälä, M. Keränen, R. Tuuminen, R. Krebs, N. Antti, K. Alitalo, K. Lemström

    Transplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki, Finland; Department of Cardiothoracic Surgery, Helsinki University Hospital, Helsinki, Finland; Molecular/Cancer Biology Program, Institute for Molecular Medicine Finland, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland

    Purpose: VEGF-C/D/VEGFR-3 signaling may regulate lymphatic vessel activation and the initiation of alloimmunity after transplantation. However, the mechanisms remain unknown. We investigated the effect of…
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