ATC Abstracts

American Transplant Congress abstracts

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  • 2013 American Transplant Congress

    Novel Candidate Markers Characterizing Cellular Senescence in Aged Zero Hour Kidney Biopsies Predict Post Transplant Outcome

    K. Kotsch, J. Guenther, P. Hutter, H. Schwelberger, M. Biebl, S. Schneeberger, R. Öllinger, A. Weissenbacher, H. Neuwirt, G. Mayer, D. Stauch, A. Pascher, P. Neuhaus, J. Pratschke

    Department for Surgery, Medical University Innsbruck, Innsbruck, Austria; Division of Nephrology, Medical University Innsbruck, Innsbruck, Austria; Department for Surgery, Charité-Universitätsmedizin Berlin, Berlin, Germany

    Advanced donor age adversely affects allograft outcome following renal transplantation. Candidate genes involved in cell-cycle regulation and telomere shortening have been already described as markers…
  • 2013 American Transplant Congress

    Toll Like Receptor Signaling Pathway Activated and Inflammation Amplified in Naked Caspase-3 siRNA Preserved Auto-Transplant Porcine Kidneys

    C. Yang, L. Li, Y. Xue, Z. Zhao, T. Zhao, Y. Jia, R. Rong, M. Xu, M. Nicholson, T. Zhu, B. Yang

    Zhongshan Hospital, Fudan University, Shanghai, Christmas Island; Shanghai Key Laboratory of Organ Transplantation, Shanghai, China; University of Leicester, Leicester General Hospital, Leicester, United Kingdom; Affiliated Hospital of Nantong University, Nantong, China

    Background. In our previous study, naked caspase-3 siRNA infused into the renal artery during cold preservation was effective, but did not protect the auto-transplant kidneys…
  • 2013 American Transplant Congress

    Mesenchymal Stem Cell Induced In-Vitro Generation of Regulatory T-Cells – Future Novel Cellular Therapy for Tolerance Induction in Transplantation?

    S. Dave, A. Vanikar, H. Trivedi

    Department of Pathology, Laboratory Medicine, Transfusion Services and Immunohematology, Institute Of Kidney Diseases & Research Centre (IKDRC)- Dr. H.L. Trivedi Institute of Transplantation Sciences (ITS), Ahmedabad, Gujarat, India; Department of Nephrology and Transplantation Medicine, Institute Of Kidney Diseases & Research Centre (IKDRC)- Dr. H.L. Trivedi Institute of Transplantation Sciences (ITS), Ahmedabad, Gujarat, India

    Introduction:Regulatory T-cells (Tregs) have recently been recognized as key players in transplantation immunobiology with little knowledge about their source and dose for tolerance induction.We present…
  • 2013 American Transplant Congress

    Assessing Cell Mediated Immunity (CMI) Status by the ImmuKnow Assay in Renal Transplant Recipients

    H. Xiang, W. Xue, P. Tian, X. Ding, X. Pan, H. Yan, J. Hou, X. Feng, X. Tian, C. Ding

    Department of Renal Transplant, Center of Nephropathy, The First Affiliated Hospital, Medical College, Xi'an Jiaotong University, Xi'an, China

    BACKGROUND: Transplant recipients have a high risk of infection due to overimmunosuppression. However, underimmunosuppression carries with it the risk of rejection. It would be necessary…
  • 2013 American Transplant Congress

    Antibodies Are Not Necessarily Detrimental to the Graft Survival – Single Centre Experience in Living Donor Renal Transplantation

    A. Vanikar, H. Trivedi, V. Kute, H. Patel, M. Gumber, P. Shah, S. Dave, V. Trivedi

    Department of Pathology, Laboratory Medicine, Transfusion Services and Immunohematology, Institute Of Kidney Diseases & Research Centre (IKDRC)- Dr. H.L. Trivedi Institute of Transplantation Sciences (ITS), Civil Hospital Campus, Ahmedabad, Gujarat, I; Department of Nephrology and Transplantation Medicine, Institute Of Kidney Diseases & Research Centre (IKDRC)- Dr. H.L. Trivedi Institute of Transplantation Sciences (ITS), Civil Hospital Campus, Ahmedabad, Gujarat, India

    Introduction: Antibodies are believed to be detrimental to graft survival. We present a cohort of living donor renal transplant (LDRTx) patients who were subjected to…
  • 2013 American Transplant Congress

    Comparative Ability of Different Metabolic Syndrome Definitions To Predict Major Adverse Cardiovascular Events after Kidney Transplantation

    G. Prasad, M. Huang, S. Silver, A. Allawati, L. Rapi, M. Nash, J. Zaltzman

    Medicine, University of Toronto, Toronto, ON, Canada; Renal Transplant Program, St. Michael's Hospital, Toronto, ON, Canada

    Background: Metabolic syndrome (MS) refers to a clustering of factors that increases cardiovascular risk. There are at least 4 definitions of MS: International Diabetes Federation…
  • 2013 American Transplant Congress

    Over-Expression of miR-499 within Donor Heart Attenuates Cardiac Allograft Vasculopathy

    X. Zhang, Z. Chen, X. Chen, P. Li, J. Yang

    Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Institute of Zoology, Chinese Academy of Sciences, Beijing, China

    Cardiac allograft vasculopathy (CAV) is a major limiting factor in the long-term success of heart transplantation. Ischemia-reperfusion injury plays a critical role in initiation of…
  • 2013 American Transplant Congress

    Novel Monitoring Panel for Tolerance-Inducing Effects of Extracorporal Photopheresis

    M. Dieterlen, H. Bittner, S. Dhein, F. Mohr, M. Barten

    Clinic for Cardiac Surgery, Heart Center Leipzig, Leipzig, Germany; Dept. Cardiothoracic Transplantation and Advanced Cardiac Surgery, Florida Hospital Orlando, Orlando

    Goal: Extracorporal photopheresis (ECP) has been used as a therapeutic option for acute and chronic rejection after transplantation. Tolerance-inducing effects of ECP after transplantation are…
  • 2013 American Transplant Congress

    TLR2 Signaling in Epithelial Cells Initiates Sterile Tissue Inflammation through Recruitment of NK Cells in Renal Ischemia Reperfusion Injury

    H. Cho, B. Kwon, J. Lee, H. Cha, H. Kim, A. Kim, S. Koo, R. Mittler

    Department of Surgery, Ulsan University Hospital,College of Medicine, University of Ulsan, Ulsan, Republic of Korea; School of Biological Sciences, University of Ulsan, Ulsan, Republic of Korea; Department of Internal Medicine, Ulsan University Hospital,College of Medicine, University of Ulsan, Ulsan, Republic of Korea; Biomedical Research Center, Ulsan University Hospital,College of Medicine, University of Ulsan, Ulsan, Republic of Korea; Department of Pathology, Ulsan University Hospital,College of Medicine, University of Ulsan, Ulsan, Republic of Korea; Department of Surgery and Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA

    It is well recognized that damage-associated molecular patterns (DAMPs) released from damaged kidney cells initiate post-ischemic inflammation, an essential step in the progression of kidney…
  • 2013 American Transplant Congress

    Alemtuzumab for Induction Therapy for Small Bowel Transplantation

    T. Vowinkel, J. Hoelzen, C. Anthoni, H. Schmidt, N. Senninger, H. Wolters

    Department of General and Visceral Surgery, University Hospital Muenster, Muenster, Germany; Clinic for Transplantation Medicine, University Hospital Muenster, Muenster, Germany

    IntroductionSmall bowel transplantation can be performed for short bowel syndrome. The ideal immunosuppressive regimen after small bowel transplantation still needs to be defined. Here we…
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