ATC Abstracts

American Transplant Congress abstracts

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  • 2013 American Transplant Congress

    Human Adipose Tissue Derived Mesenchymal Stem Cells Aggravate Chronic Cyclosporin Nephrotoxicity by the Induction of Oxidative Stress

    B. Chung, S. Lim, K. Doh, S. Piao, S. Heo, C. Yang

    Internal Medicine, Seoul St. Mary's Hospital, Seoul, Korea

    Cyclosporine (CsA) induced nephrotoxicity is an important complications to limit the long term allograft outcome in kidney transplantation. The aim of this study was to…
  • 2013 American Transplant Congress

    Addition of Anti-CMV Ig to Routine CMV Prophylaxis in EBV High Risk Kidney Transplant Recipients Is Associated with Reduced PTLD Incidence

    A. Shields, E. Woodle, R. Alloway, S. Safdar, S. Huang, M. Cardi

    Transplant, University of Cincinnati; Transplant, The Christ Hospital

    Epstein-Barr virus (EBV) seronegative patients (pts) who receive a kidney from an EBV seropositive donor carry the highest risk for EBV-related PTLD. We report our…
  • 2013 American Transplant Congress

    Genetic Polymorphism rs10912564 in TNFSF4 of the TNF Superfamily Is Associated with HCT Outcomes

    P. Jindra, S. Conway, S. Ricklefs, S. Porcella, G. Alterovitz, T. Wang, S. Spellman, D. McDermott, R. Abdi

    Transplant Research Center, Renal Division, Brigham and Women's Hospital and Children's Hospital, Boston, MA; Genomics Unit, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MO; Children&s Hospital Informatics, Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Boston, MA; Division of Biostatistics, Medical College of Wisconsin, Milwaukee, WI; Center for International Blood and Marrow Transplant Research, Minneapolis, MN; Molecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD

    TNFSF4 is a costimulatory molecule that is important for T cell activation. In this study, we used multivariate Cox regression models to determine whether a…
  • 2013 American Transplant Congress

    Racial and Ethnic Differences in Determinants of Live Donor Kidney Transplantation in the United States

    T. Purnell, P. Xu, N. Leca, Y. Hall

    Johns Hopkins University, Baltimore; University of Washington, Seattle

    Purpose: Our objective was to examine racial/ethnic differences in determinants of live-donor kidney transplantation (LDKT) across all major US racial/ethnic groups.Methods: We performed a retrospective…
  • 2013 American Transplant Congress

    APOL1 and MHY9 Gene Variants and Allograft Outcomes in Kidney Transplantation

    A. Israni, W. Guan, D. Schladt, W. Oetting, P. Jacobson, A. Matas, for DEKAF Genomics Study

    Medicine, Hennepin County Medical Center, University of Minneosta (UMN), Minneapolis, MN; Biostatistics, UMN, Minneapolis; MMRF, Minneapolis; Pharmacy, UMN, Minneapolis; Surgery, UMN, Minneapolis

    Background: Single nucleotide polymorphisms (SNPs) in APOL1 and nearby MHY9 gene have been consistently associated with increased risk of ESKD in African Americans (AA) in…
  • 2013 American Transplant Congress

    Outcomes of Influenza Infection in Adult Hematopoietic Stem Cell Transplant and Lung Transplant Recipients Compared to Non Transplant Patients

    A. Guedes de Morais, D. van Duin, N. Shrestha, S. Mossad

    Infectious Disease, Cleveland Clinic, Cleveland, OH

    Background:After the Influenza A H1N1 pandemic infection of 2009 there was increased concern regarding worse clinical presentations in transplant recipients. We compared outcomes of influenza…
  • 2013 American Transplant Congress

    Impact of Induction Agent on Repeat Kidney Transplant Outcomes in Patients on Maintenance Immunosuppression

    N. Wilson, W. Manitpisitkul, M. Jason, B. Noell, M. Weir, S. Bartlett, J. Bromberg, A. Haririan

    University of MD Medical Ctr, Baltimore

    Background: 12% of kidney transplant recipients each year have undergone previous transplantation. The optimal induction therapy in the subgroup of patients who are on maintenance…
  • 2013 American Transplant Congress

    Locally-Delivered CD4+CD25highFoxp3+ Regulatory T Cells Combined with Systemic KRP203 Therapy Induces Tolerance to Islet Allografts

    C. Baum, M. Khattar, R. Deng, B. Kahan, P. Schroder, T. Phan, L. Rutzky, S. Stepkowski

    Medical Microbiology & Immunology, University of Toledo College of Medicine, Toledo, OH; Division of Immunology & Organ Transplantation, Department of Surgery, University of Texas Medical School, Houston, TX

    Background: KRP203, a structural FTY720 analog, has 5-fold greater selectivity for binding to sphingosine-1-phosphate receptor 1 (S1PR1) versus S1PR3 and 100-fold greater selectivity versus S1PR2…
  • 2013 American Transplant Congress

    BK Virus (BKV) Infection in Renal Transplantation: Excellent Outcomes with a Protocol of Intensive Post-Transplant Screening with Reduction in Immunosuppression & Treatment with Leflunomide and/or Low Dose Cidofovir

    C. Varma, G. Cipollina, M. Le, M. Gupta, A. Kotru

    Transplant & Liver Surgery, Geisinger Medical Center, Danville, PA

    Purpose: BKV infection is associated with a progressive decline in renal function in renal transplant recipients with a significant incidence of graft loss (30-40%) in…
  • 2013 American Transplant Congress

    Disparate Performance of Two Commonly Used Glomerular Filtration Rate Estimation Equations in Lung Transplant Patients

    B. Stephany, E. Poggio, E. Wehbe

    Nephrology & Hypertension, Cleveland Clinic, Cleveland, OH; The Kidney Institute, Nephrology, Dialysis & Transplantation, Houston, TX

    Purpose: The abbreviated Modification of Diet in Renal Disease (MDRD) and CKD-Epi equations employ the same variables (creatinine, race, gender) and are both commonly used…
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