2013 American Transplant Congress
Proteasome Inhibition Protects Steatotic Liver Graft through Modulation of the AMPK, Akt and mTOR Pathways
Background: Hepatic steatosis presents a major challenge in liver transplantation. Steatotic livers show an increased susceptibility to cold ischemia and reperfusion (CIR) injury. The mechanisms…2013 American Transplant Congress
Critical Analysis of Death within 1 Year after Liver Transplantation, A
Abdominal Transplnatation, University of Arizona, Tucson
Context: In the current era, 15% of liver transplant recipients die within the first year. While this may be viewed as a feat in comparison…2013 American Transplant Congress
Impact of Recipient Body Mass Index in Short and Long Term Survival of Pancreatic Grafts
Background: In pancreas transplantation, the impact of recipient BMI on short and long term pancreas graft survival has not been studied.Methods: We analyzed data from…2013 American Transplant Congress
Combined Costimulatory and OX40L Blockade Significantly Prolongs Transplant Survival in Mice and Non-Human Primates
Emory Transplant Center, Atlanta, GA; Juntendo University, Tokyo, Japan; Roche USA, New York, NY
Belatacept is the first clinically approved transplant immunosuppressant based on costimulatory blockade (CoB). Kidney transplant recipients treated with belatacept had improved long-term renal function, albeit…2013 American Transplant Congress
Open-Label Study of Planned Transition from Tacrolimus to Sirolimus vs Continued Tacrolimus in Renal Allograft Recipients: Demographics and Interim Safety Results
Purpose: Evaluate planned transition from tacrolimus (TAC) to sirolimus (SRL) vs continued TAC in renal allograft recipients.Methods: This open-label, randomized, multinational phase 4 study screened…2013 American Transplant Congress
Clinical Risk Stratification Predicts Ischemic Cardiovascular Complications after Kidney Transplantation with High Sensitivity and Specificity
The predictive value of noninvasive cardiac test remains unclear in the kidney transplant(KT) population. We evaluated the performance of noninvasive tests and clinical risk stratification…2013 American Transplant Congress
Complication Free Heterotopic Cardiac Xenograft Survival by Anti CD40 Antibody Mediated Co-Stimulation Blockade
Introduction: Despite achieving longest reported graft survival by us via anti CD154 mediated co stimulation blockade, many coagulation disorders were witnessed due to direct binding…2013 American Transplant Congress
Alemtuzumab Induction in HCV Seropositive Kidney Transplant Recipients
Transplant Division, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY
Background: Alemtuzumab (AZ) is a humanized anti-CD52 monoclonal antibody used as an induction agent in organ transplantation. The potency of alemtuzumab, is a concern for…2013 American Transplant Congress
Real-Time Three-Dimensional Fourier-Domain Optical Coherence Tomography for Intravital Imaging of Thrombosis after Vascularized Composite Allotransplantation Procedures
Purpose: We sought to apply real-time three-dimensional Fourier-domain optical coherence tomography (3D FD-OCT) for in vivo monitoring of vascular thrombosis and thrombolysis.Methods: 10% Ferric chloride…2013 American Transplant Congress
Discriminating among the Sickest Cohorts in Liver Transplantation: An Application of the SOFT Score
Abdominal Transplantation, University of Arizona, Tucson, AZ
Context: Models that discriminate among the sickest cohorts in liver transplantation are important to optimize outcomes. We introduced the Survival Outcomes Following Liver Transplantation (SOFT)…
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