ATC Abstracts

American Transplant Congress abstracts

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  • 2013 American Transplant Congress

    Unlicensed NK Cells Differentiated from CD34+Hematopoietic Progenitor Cells Exhibit Anti-HCC and Anti-HCV Activity

    R. Hotta, Y. Tanaka, S. Shimizu, M. Ohira, K. Ishiyama, N. Hiraga, K. Chayama, H. Ohdan

    Hiroshima University, Hiroshima, Japan

    We have previously shown that IL-2–stimulated NK cells derived from the liver exert vigorous cytotoxicity against HCC by their binding to the TRAIL expressed on…
  • 2013 American Transplant Congress

    Risk Factors of Post-Transplant High-Grade CMV Reactivation in CMV-Seropositive Patients in the Modern Immunosuppressive Era

    M. Saito, S. Satoh, K. Numakura, T. Inoue, H. Tsuruta, S. Akihama, N. Tsuchiya, T. Habuchi

    Urology, Akita University Graduate School of Medicine, Akita, Japan

    Backgrounds: Cytomegalovirus (CMV) prophylaxis is recommended for CMV-seronegative kidney transplant recipients (R-) receiving the grafts from CMV seropositive donors (D+). Meanwhile, whether R+ patients need…
  • 2013 American Transplant Congress

    Reperfusion Time Alters Kidney microRNA Expression in Rodent Ischemia-Reperfusion Injury

    T. Merchen, E. Boesen, N. Nahman Jr, R. Podolsky, R. Harbarger, A. Ghaffari, J. Wynn, A. Mellor, D. Pollock

    Surgery, Georgia Health Sciences Center, Augusta, GA; Medicine, Georgia Health Sciences Center, Augusta, GA; Medicine, Charlie Norwood VAMC, Augusta, GA; Center for Biotechnology and Genomics, Georgia Health Sciences Center, Augusta, GA

    Background: Ischemia-reperfusion injury (IRI) in kidney transplantation is associated with delayed graft function and chronic allograft injury. microRNA (miRNA) are part of a population of…
  • 2013 American Transplant Congress

    Does Stress Impair Wound Healing Measured by High-Resolution Ultrasound in Living Kidney Donors? A Pilot Study

    H. Maple, S. Simmonds, M. Tran, J. Chilcot, J. Weinman, N. Mamode

    Abdominal Medicine and Surgery, Guy's and St Thomas' Hospital NHS Foundation Trust, London, United Kingdom; Psychology as Applied to Medicine, Institute of Psychiatry (King's College London), London, United Kingdom

    Background: Stress has been demonstrated as a factor that influences the rate of wound healing. Living kidney donors are an ideal group on which to…
  • 2013 American Transplant Congress

    Delayed Anti-CD3 Therapy Results in Depletion of Alloreactive T Cells and the Dominance of Foxp3+CD4+ Graft Infiltrating Cells

    R. Goto, S. You, M. Zaitsu, L. Chatenoud, K. Wood

    Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom; Université Paris Descartes, Institut National de la Santé et de la Recherche Médicale Unit 1013, Paris, France

    Background. The engineered Fc-nonbinding CD3 antibody has lower mitogenicity and a precise therapeutic window for disease remission in patients with type 1 diabetes. Before anti-CD3…
  • 2013 American Transplant Congress

    Analysis of Motivation and Anonymity in 117 Unspecified (Altruistic) Donors in the UK

    H. Maple, J. Chilcot, L. Burnapp, A. Santhouse, J. Weinman, N. Mamode

    Abdominal Medicine and Surgery, Guy's Hospital, London, United Kingdom; Psychology as Applied to Medicine, King's College London, London, United Kingdom; Organ Donation and Transplantation Directorate, NHS Blood and Transplant, Bristol, United Kingdom; Institute of Psychiatry (King's College London), London, United Kingdom

    Introduction: Unspecified (altruistic) donation is becoming increasingly popular in the UK. Concerns persist about donor motivations, regret and long-term psychosocial outcomes. The aims of this…
  • 2013 American Transplant Congress

    Clinicopathological Analysis of Persistent Hyperparathyroidism after Kidney Transplantation in Long-Term Dialysis Patients

    M. Nakamura, H. Shirai, K. Tanaka, Y. Marui, S. Tomikawa

    Transplant Surgery, Tokai University School of Medicine, Isehara, Kanagawa, Japan; Kidney Center, Toranomon Hospital, Minatoku, Tokyo, Japan

    Background: Deceased donor kidney transplantation in long-term dialysis patients in Japan has been increasing because of a severe lack of donors. Parathyroid glands of long-term…
  • 2013 American Transplant Congress

    Impact of Gamma Chain Cytokines on Cytotoxic T Lymphocyte Function for the Treatment of Viral Infections

    M. Schmueck, S. Sarmadi, B. Weist, N. Babel, H. Volk, P. Reinke

    Institute of Medical Immunology, Charité Universitätsmedizin Berlin, Berlin, Germany; Berlin-Brandenburg Center for Regenerative Therapies, Charité Universitätsmedizin Berlin, Berlin, Germany; Department of Nephrology and Intensive Care, Charité Universitätsmedizin Berlin, Berlin, Germany

    Human cytomegalovirus (CMV) infection or reactivation is a frequent cause of morbidity and mortality in immunocompromised individuals, such as solid organ transplant recipients. The adoptive…
  • 2013 American Transplant Congress

    Duct-to-Duct Biliary Reconstruction in Liver Transplantation for Primary Sclerosing Cholangitis Is Associated with Less Biliary Complications, Compared with Roux-en-Y Hepatico-Jejunostomy

    M. Sutton, R. Bense, T. Lisman, E. van der Jagt, A. van den Berg, R. Porte

    Surgery, University Medical Center Groningen, Groningen, Netherlands; Radiology, University Medical Center Groningen, Groningen, Netherlands; Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, Netherlands

    Background:Although duct-to-duct anastomosis has been shown as a feasible option for biliary reconstruction in patients undergoing orthotopic liver transplantation (OLT) for end-stage primary sclerosing cholangitis…
  • 2013 American Transplant Congress

    Prioritization Due to Dialysis Access Failure Impacts on Patient Survival after Kidney Transplantation

    J. Reusing Jr., P. Souza, N. Galante, F. Agena, F. de Paula, W. Nahas, E. David-Neto

    Renal Transplant Service, Hospital das Clínicas University of São Paulo, São Paulo, Brazil

    Dialysis vascular access failure, recipient of a non-renal solid organ transplantation and previous kidney donation are current indications of priority allocation (PA) for kidney transplant…
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