2013 American Transplant Congress
Indoleamine 2, 3-Dioxygenase Inhibition Alters Noncoding RNAs Following Ischemia-Reperfusion Injury of the Kidney
Background: Non-coding RNAs (NCR) arise from the non-protein-coding portion of the genome and include microRNAs, small nucleolar RNAs (snoRNA) and ribosomal RNAs (rRNA). NCR are…2013 American Transplant Congress
Interplay between mTOR and STAT5 Signaling Modulates the Balance between Regulatory and Effective T Cells
West China Hospital, Sichuan University, chengdu, China
Background: Allograft outcome, rejection or tolerance, often depends on the balance between regulatory T cells (Tregs) and effective T cells (Teffs). Rapamycin (Rapa) has been…2013 American Transplant Congress
α-Lipoic Acid Protects the Ischemia Reperfusion Injury in Simultaneous Kidney-Pancreas Transplant Patients
Α-lipoic acid (ALA) is a potent antioxidant. ALA is proposed to mitigate the development of diabetic polyneuropathy by addressing reactive oxygen and nitrogen species. ALA…2013 American Transplant Congress
Sildenafil Enhances Renal Blood Flow but Does Not Protect Against Ischaemia Reperfusion Injury in a Model of Donation after Circulatory Death Kidney Transplantation
IntroductionSildenafil has been used as a pre-conditioning agent to protect against ischaemic kidney injury in a porcine cardio-pulmonary bypass model (Patel NN et al, Ann…2013 American Transplant Congress
Non-Influenza Respiratory Viral Infections in Solid Organ Transplant Patients at Two Midwestern Transplant Centers, 2009-2012
Purpose: Expanded availability of multi-pathogen PCR assays has allowed the detection of common respiratory viruses in clinical specimens. Few studies have investigated the epidemiology and…2013 American Transplant Congress
Acute T-Cell Mediated Rejection with Severe Tubulitis or Mild Intimal Arteritis: Which Histological Lesion Predicts Better Graft Outcome?
Background: Acute T-cell-mediated rejection (TCMR) is divided by Banff classification into tubulo-interstitial rejection and vascular rejection according to the presence of arteritis. Vascular rejection is…2013 American Transplant Congress
Balance between Interleukin 17-Secreting T Helper Cells and Regulatory T Cells after Renal Transplantation: Relation to Graft Function and Survival, The
Background: Repeated attacks of acute rejection can result in chronic allograft dysfunction (CAD) which is the most prevalent cause of graft loss. T helper (Th)…2013 American Transplant Congress
Liver Transportation Time Model and Comparison with Cold Ischemia Time
Background: Prolonged cold ischemia time (CIT) is associated with worse outcomes after deceased donor liver transplant. One factor influencing CIT is transport time, the time…2013 American Transplant Congress
Disappearance of Immunoglobulin Producing Plasmablasts in Kidney Transplant Patients Is Associated with a Diminished Cytokine Producing Capacity by Peripheral Follicular T-Lymphocytes
Internal Medicin & Transplant Immunology, Erasmus MC, Rotterdam, South-Holland, Netherlands
BACKGROUND Follicular T-helper cells (Thf-cells) play a pivotal role in the differentiation of B-cells into Ig secreting cells, i.e. plasmablasts. CD4+CXCR5+ T-cells are their peripheral…2013 American Transplant Congress
Population Pharmacokinetics of Voclosporin: Body Surface Area Optimized Dosing
Objective:To determine the population pharmacokinetics (popPK) of voclosporin (VCS), a new calcineurin inhibitor (CNi), and explore potential covariate relationships to individualize drug dosing.Background:Inter and intra-individual…
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