ATC Abstracts

American Transplant Congress abstracts

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  • 2013 American Transplant Congress

    CCR2 Dependent Migration Is Absolutely Required for Myeloid Suppressor Cells To Protect Cell Transplants

    J. Qin, Y. Arakawa, J. Fung, S. Qian, L. Lu

    Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH; General Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH

    Whole organ transplantation gets great success, while the outcomes of cell transplants remain poor, suggesting a critical role of non-parenchymal cells in immune regulation. Through…
  • 2013 American Transplant Congress

    Kidney Transplantation: Pre and Post-Transplant Immunological Evaluation and Outcome of Recipients in Low, Medium, and High Risk of Rejection

    S. Abrahao, R. Oliveira, A. Pereira, F. Junior, M. Maciel, B. Vilela, C. Filho, R. Gontijo, E. Nascimento

    Laboratorio de Histocompatibilidade, Imunogenetica e Imunologia de Transplantes, IMUNOLABTx, Belo Horizonte, Minas Gerais, Brazil; Hospital das Clínicas, Universidade Federal de Minas Gerais, Beloo Horizonte, Minas Gerais, Brazil; MG Transplantes, FHEMIG, Belo Horiznte, Minas Gerais, Brazil; Instituto de Ensino e Pesquisas, Clínica de Transplantes, Santa Casa de Belo Horizonte, Belo Horizonte, Minas Gerais, Brazil

    Specific antibodies (AB) against donor (DSA) have a fundamental role in the mechanism of kidney (K) transplant rejection and represent one of the main barriers…
  • 2013 American Transplant Congress

    Prolonged Cardiac Allograft Survival Due to Treg Expansion in Recipient BAFF-Tg Mice

    M. Saito, G. Zhang, Y. Wang, M. Hu, S. Walters, J. Zhou, A. Sawyer, J. Chapman, S. Grey, S. Alexander

    Centre for Kidney Research, Children's Hospital at Westmead, Sydney, Australia; Centre for Transplant and Renal Research, Westmead Hospital, Sydney, Australia; Gene Therapy & Autoimmunity Group, Immunology and Inflammation Program, Garvan Institute of Medical Research, Sydney, Australia

    Background: B cell activation factor of the TNF family (BAFF) is considered to function as a proinflammatory cytokine. BAFF is crucial for B cell development…
  • 2013 American Transplant Congress

    Induction of Donor Specific Hyporesponsiveness in Kidney Transplantation Using Adoptive Transfer of Ex Vivo Induced Tolerogenic Cells

    I. Koyama, H. Bashuda, K. Seino, K. Kai, T. Murakami, A. Sannomiya, I. Nakajima, S. Fuchinoue, K. Okumura, S. Teraoka

    Tokyo Women's Medical University, Tokyo, Japan; Juntendo University, Tokyo, Japan; Hokkaido University, Sapporo, Japan; International University of Health and Welfare, Atami, Japan

    [Background] Anergic T cells generated ex vivo under conditions of co-stimulatory blockade are reported to have tolerogenic effects. According this finding, we have conducted the…
  • 2013 American Transplant Congress

    Prospective Randomized Trial Aimed To Reduce the Incidence of Cytomegalovirus (CMV) Infection in Kidney Transplant (KT) Recipients, A

    H. Tedesco, C. Felipe, L. Wang, C. Rodrigues, T. Sandes, M. Cristelli, M. Franco, J. Medina-Pestana

    Nephrology Division, Hospital do Rim e Hipertensão, São Paulo, Brazil

    Introduction: CMV infection has been associated with inferior long-term patient and graft survival. This single center prospective study compares the effect of 3 immunosuppressive regimens…
  • 2013 American Transplant Congress

    Indoleamine 2, 3-Dioxygenase Inhibition Alters Noncoding RNAs Following Ischemia-Reperfusion Injury of the Kidney

    T. Merchen, E. Boesen, R. Harbarger, A. Ghaffari, A. Mellor, J. Wynn, R. Podolsky, D. Pollock, N. Nahman Jr

    Surgery, Georgia Health Sciences University, Augusta, GA; Center for Biotechnology and Geonomic, Georgia Health Sciences University, Augusta, GA; Medicine, Georgia Health Sciences University, Augusta, GA; Medicine, Charlie Norwood VAMC, Augusta, GA

    Background: Non-coding RNAs (NCR) arise from the non-protein-coding portion of the genome and include microRNAs, small nucleolar RNAs (snoRNA) and ribosomal RNAs (rRNA). NCR are…
  • 2013 American Transplant Congress

    Interplay between mTOR and STAT5 Signaling Modulates the Balance between Regulatory and Effective T Cells

    J. Shan, L. Feng, Y. Li

    West China Hospital, Sichuan University, chengdu, China

    Background: Allograft outcome, rejection or tolerance, often depends on the balance between regulatory T cells (Tregs) and effective T cells (Teffs). Rapamycin (Rapa) has been…
  • 2013 American Transplant Congress

    α-Lipoic Acid Protects the Ischemia Reperfusion Injury in Simultaneous Kidney-Pancreas Transplant Patients

    D. Guerrieri, J. Petroni, A. Nicolás, V. Arrosagaray, P. Uva, E. Chuluyan, D. Casadei, C. Incardona

    CEFYBO-CONICET, Facultad de Medicina, UBA, Buenos Aires, Argentina; Instituto de Nefrología Buenos Aires, Buenos Aires, Argentina; Fundación GADOR, Buenos Aires, Argentina

    Α-lipoic acid (ALA) is a potent antioxidant. ALA is proposed to mitigate the development of diabetic polyneuropathy by addressing reactive oxygen and nitrogen species. ALA…
  • 2013 American Transplant Congress

    Sildenafil Enhances Renal Blood Flow but Does Not Protect Against Ischaemia Reperfusion Injury in a Model of Donation after Circulatory Death Kidney Transplantation

    L. Randle, S. Hosgood, M. Patel, C. Watson, J. Bradley, M. Nicholson

    Department of Surgery, University of Cambridge, Cambridge, United Kingdom; Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom

    IntroductionSildenafil has been used as a pre-conditioning agent to protect against ischaemic kidney injury in a porcine cardio-pulmonary bypass model (Patel NN et al, Ann…
  • 2013 American Transplant Congress

    Non-Influenza Respiratory Viral Infections in Solid Organ Transplant Patients at Two Midwestern Transplant Centers, 2009-2012

    N. Theodoropoulos, S. Martin, B. Ho, M. Ison

    Division of Infectious Diseases, The Ohio State University College of Medicine, Columbus; Northwestern University, Chicago; Northwestern University Transplant Outcomes Collaboration, Chicago

    Purpose: Expanded availability of multi-pathogen PCR assays has allowed the detection of common respiratory viruses in clinical specimens. Few studies have investigated the epidemiology and…
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