ATC Abstracts

American Transplant Congress abstracts

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  • 2013 American Transplant Congress

    Flow Is Critical for Maintaining a Protective Phenotype in Renal Proximal Tubular Cells

    M. Timsit, W. Adams, A. Laguna-Fernandez, T. Ichimura, J. Bonventre, G. Garcia-Cardena, S. Tullius

    Transplant Surgery Research Lab, Harvard Medical School, Brigham and Women's Hospital, Boston, MA; Laboratory for Systems Biology, Center for Excellence in Vascular Biology, Harvard Medical School, Brigham and Women's Hospital, Boston, MA; Renal Division, Harvard Medical School, Brigham and Women's Hospital, Boston, MA; Université Paris Descartes, Sorbonne Paris Cité, Paris, France

    Background. The impact of flow cessation on proximal tubular cell homeostasis and glomerulotubular balance is of clinical significance during renal ischemia and organ preservation. Consequences…
  • 2013 American Transplant Congress

    Pre-Transplant Immediately Early-1-Specific T-Cell Responses Provides Protection for CMV Infection after Kidney Transplantation

    O. Bestard, M. Lucia, E. Crespo, J. Cruzado, D. Palacio, E. Melilli, J. Torras, S. Gil-Vernet, J. Grinyó

    Renal Transplant Unit, Nephrology Department, Bellvitge University Hospital, Barcelona, Spain; Experimental Nephrology Department, IDIBELL, Barcelona, Spain; Nefrology Department, Hospital San Vicente de Paul, Bogota, Colombia

    Human cytomegalovirus (CMV) infection is still a major complication after kidney transplantation. Although it is well known that cytotoxic CMV-specific CD8+ T cells play a…
  • 2013 American Transplant Congress

    Hypothermic Machine Perfusion To Optimise the Timing of Renal Transplantation

    A. Guy, M. Field, H. Krishnan, N. Inston, A. Ready

    Renal Surgery, University Hospitals Birmingham NHS Foundation Trust, Birmingham, West Midlands, United Kingdom

    BackgroundConflict has always existed between Cold Ischaemic Time (CIT) and safe, timely transplantation. Keeping CIT short may entail operating on complex patients with considerable co-morbidity…
  • 2013 American Transplant Congress

    Soluble BAFF Levels Correlate with De Novo DSA Development and Progression to Chronic Active Antibody-Mediated Rejection in Pediatric Recipients of First Kidney Transplants

    P. Comoli, G. Quartuccio, M. Cioni, A. Parodi, I. Fontana, S. Basso, A. Magnasco, A. Tagliamacco, A. Nocera, M. Cardillo, F. Ginevri

    Pediatric Hematology/Oncology, IRCCS Fondazione S. Matteo, Pavia, Italy; Pediatric Nephrology, G. Gaslini Institute, Genova, Italy; Department of Surgery, IRCCS San Martino, Genova, Italy; Transplantation Immunology, Fondazione Cà Granda Ospedale Maggiore Policlinico, Milano, Italy

    De novo donor-specific antibody (dnDSA) development is associated with late/chronic active antibody-mediated rejection (CAMR) and graft failure in low-risk kidney recipients. It has been recently…
  • 2013 American Transplant Congress

    Effects of Hepatic Impairment on Single and Multiple Oral Dose Pharmacokinetics of Voclosporin (VCS)

    L. Aspeslet, D. Freitag, R. Huizinga, P. Mayo, S. Ling, R. Foster

    Isotechnika Pharma Inc, Edmonton, AB, Canada

    Objective:To determine the pharmacokinetic profile of VCS in subjects with hepatic impairment after single or multiple doses.Methods:VCS 0.4 mg/kg was administered to subjects with hepatic…
  • 2013 American Transplant Congress

    Simple Cardiovascular Risk Score Predicts Mortality in Kidney Transplant Candidates, A

    C. Lawrence, S. Cruickshank, A. Manoj, S. Mathavakkannan, S. Chandna, S. Fluck, K. Farrington

    Renal Unit, Lister Hospital, Stevenage, United Kingdom

    For patients with renal failure kidney transplantation (KTx) confers improved quality and length of life. The survival benefit from KTx is limited by death from…
  • 2013 American Transplant Congress

    Dual Kidney Transplants from Marginal Donors: Double or Nothing

    Y. Al-shraideh, A. Farney, J. Rogers, G. Orlando, U. Farooq, R. Stratta

    Surgery, Wake Forest School of Medicine, Winston Salem, NC

    The purpose of this study was to review retrospectively our single center experience with adult dual kidney transplants (DKT) from marginal donors with limited nephron…
  • 2013 American Transplant Congress

    Concomitant Azathioprine and Warfarin Warrants Significant Warfarin Dosage Increase

    L. Bowman, K. Bain, J. Hagopian, J. Iuppa, J. Shuster, T. Horwedel

    Barnes-Jewish Hospital, St. Louis, MO

    Purpose: The concomitant use of azathioprine (AZA) and warfarin (WAR) occurs commonly in solid organ transplant (SOT) recipients. Case reports in non-SOT patients have suggested…
  • 2013 American Transplant Congress

    Liver Allografts Do Not Always Protect from Kidney Allograft Rejection in Sensitized Recipients of Simultaneous Liver-Kidney Transplants

    O. Bestard, J. Cruzado, O. Taco, L. Lladó, E. Melilli, J. Fabregat, S. Gil-Vernet, A. Rafecas, J. Grinyó

    Renal Transplant Unit, Nephrology Department, Bellvitge University Hospital, Barcelona, Spain; Liver Transplant Unit, Bellvitge University Hospital, Barcelona, Spain; Nefrology Department, Hospital San Vicente de Paul, Bogota

    Objectives: To determine the impact of pre-existing and de novo circulating anti-HLA antibodies (DSA or not, in simultaneous liver-kidney transplants (SLKT).Methods: Thirty-nine adult recipients underwent…
  • 2013 American Transplant Congress

    Coronary Angiography in Asymptomatic Kidney Transplant Candidates?

    C. Lawrence, S. Cruickshank, A. Manoj, S. Mathavakkannan, S. Chandna, S. Fluck, K. Farrington

    Renal Unit, Lister Hospital, Stevenage, United Kingdom

    Patients with end stage renal failure are at high risk of coronary artery disease (CAD). In transplant patients death with function due to cardiovascular disease…
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