ATC Abstracts

American Transplant Congress abstracts

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  • 2013 American Transplant Congress

    Early Acute Rejection (AR) Initiates Alloimmune Mechanisms Ultimately Leading to Kidney Graft Failure

    M. El Ters, M. Keddis, E. Rodrigo, A. Muriithi, M. Stegall, F. Cosio

    Nephrology,Transplant Center, Mayo Clinic, Rochester, MN; Surgery, Transplant Center, Mayo Clinic, Rochester, MN

    Introduction: AR increases risk of kidney allograft failure. The exact process by which AR leads to graft loss is yet unclear. We examined the causes…
  • 2013 American Transplant Congress

    Is Dysfunction of the HNF-1 Beta Gene Involved in the Pathogenesis of New-Onset Diabetes after Transplantation?

    G. van Boekel, M. van den Beukel, B. de Kort, C. Lamper, M. Strik, L. Hilbrands

    Nephrology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands

    Background: A dysfunction of the HNF-1beta gene can lead to renal loss of magnesium, hyperuricemia and diabetes mellitus. There is a striking similarity between this…
  • 2013 American Transplant Congress

    Reducing HIV / HCV Infection Transmission from Organ Transplantation through Nucleic Acid Testing of All Potential Deceased Donors: A Cost-Effectiveness Analysis

    J. Lai, J. Kahn, M. Tavakol, M. Peters, J. Roberts

    UCSF, San Francisco

    Background: Compared to antibody (Ab) tests, nucleic acid-amplification tests (NAT) shorten the window period during which HIV/HCV infection cannot be detected. We aimed to evaluate…
  • 2013 American Transplant Congress

    Histology One Year Post-Kidney Transplant Relates to Risk of Alloimmune-Mediated Graft Failure Long Term

    M. El Ters, L. Cornell, E. Rodrigo, M. Keddis, A. Muriithi, M. Stegall, F. Cosio

    Nephrology,Transplant Center, Mayo Clinic, Rochester, MN; Pathology, Mayo Clinic, Rochester, MN; Surgery, Transplant Center, Mayo Clinic, Rochester, MN

    Introduction. One year protocol biopsies (PBx) distinguish a large group of grafts with normal histology/mild fibrosis (GIF) and low risk of failure (LwR) from a…
  • 2013 American Transplant Congress

    Sterile Leukocyturia Predicts Interstitial Fibrosis and Tubular Atrophy in Kidney Allograft Protocol Biopsies

    S. Coelho, O. Bestard, N. Porta, E. Melilli, O. Taco, I. Rivas, J. Grinyo, J. Cruzado

    Nephrology, Hospital Fernando Fonseca, Lisbon, Portugal; Nephrology, Hospital de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain; Biostatistics, UCICEC-CAIBER, IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain

    In kidney allograft protocol biopsies the presence of interstitial fibrosis and tubular atrophy (IF/TA) is associated with graft loss. In this study we sought to…
  • 2013 American Transplant Congress

    Impact of Anatomical Variations and Insufficient Liver Volume on Living Liver Donation, The

    W. Al-hamoudi, N. Allam, H. Elsiesy, A. Hashim, B. Hegab, Y. El-Sheikh, M. Al-sofayan, H. Albahili, D. Broering, M. Al sebayel, F. Abaalkhail

    King Saud University, Riyadh, Saudi Arabia; Liver Transplantatiom, King Faisal Specialist Hospital, Riyadh, Saudi Arabia

    Background and Aims: Organ shortage has been the ongoing obstacle to expand liver transplantation world-wide including Saudi Arabia. Living donor liver transplantation (LDLT) was hoped…
  • 2013 American Transplant Congress

    Project NOTIFY: A Global Database of Serious Adverse Events and Reactions in Organs, Tissues, and Cells

    M. Ison, D. Strong, D. Fehily, E. Chatzixiros, A. Costa, L. Noel

    Divisions of Infectious Diseases & Organ Transplantation, Northwestern University, Chicago; Orthopaedics and Sports Medicine, University of Washington, Seattle; National Transplant Center (CNT), Rome, Italy; Department of Essential Health Technologies, World Health Organization, Geneva, Switzerland

    Background: Serious adverse reactions and events (SAREs) are a threat to the safety and outcome of transplantation. World Health Assembly Resolution WHA 63.22 urges Member…
  • 2013 American Transplant Congress

    Pharmacokinetics of Voclosporin (VCS) in Renal Impairment, The

    L. Aspeslet, D. Freitag, R. Huizinga, P. Mayo, S. Ling, R. Foster

    Isotechnika Pharma Inc, Edmonton, Canada

    Objective:To determine the pharmacokinetic profile of VCS in subjects with renal impairment.Methods:VCS 0.4 mg/kg was administered to subjects with Normal, Mild, Moderate, or Severe renal…
  • 2013 American Transplant Congress

    Intrahepatic Cholangiocarcinoma (I-CC) or Mixed Hepatocellular-Cholangiocarcinoma (HCC-CC) in Patients Undergoing Liver Transplantation (LT). A Spanish Case Control Multicenter Study

    R. Charco, G. Sapisochin, C. Rodriguez-Lope, M. Gastaca, J. Ortiz de Urbina, R. Lopez-Andujar, F. Palacios, E. Ramos, J. Fabregat, J. Castroagudin, E. Varo, J. Pons, P. Parrilla, M. Gonzalez-Dieguez, M. Rodriguez, A. Otero, M. Vazquez, G. Zozaya, J. Herrero, G. Sanchez Antolin, B. Perez, R. Ciria, S. Rufián, Y. Fundora, J. Ferrón, A. Guiberteau, G. Blanco, M. Varona, M. Barrera, M. Suarez, J. Santoyo, J. Bruix

    Hosital Universitario Vall d'Hebron, Barcelona, Spain; Hospital Clinic, University of Barcelona, IDIBAPS, Barcelona, Spain; Hospital Universitario de Cruces. Universidad del Pais Vasco, Bilbao, Spain; Hospital Universitario La Fe, Valencia, Spain; Hospital Universitraio de Bellvitge, L'Hospitalet de Llobregat, Spain; Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain; Hospital Virgen de la Arrixaca, Murcia, Spain; Hospital Central de Asturias, Oviedo, Spain; Hospital Universitario de A Coruña, La Coruña, Spain; Clinica Universitaria de Navarra, Pamplona, Spain; Hospital Rio Hortega, Valladolid, Spain; Hospital Universitario Reina Sofia, Córdoba, Spain; Hospital Universitraio Virgen de las Nieves, Granada, Spain; Hospital Universitario Infanta Cristina, Badajoz, Spain; Hospital Universitario Nuestra Señora de la Candelaria, Santa Cruz de Tenerife, Spain ; Hospital Carlos Haya, Malaga, Spain

    Aim: to evaluate the outcome of patients with HCC-CC or I-CC at explant pathology after LT for suspected HCC.Methods:A case-control study 1:2. Study group(n=42) formed…
  • 2013 American Transplant Congress

    Flow Is Critical for Maintaining a Protective Phenotype in Renal Proximal Tubular Cells

    M. Timsit, W. Adams, A. Laguna-Fernandez, T. Ichimura, J. Bonventre, G. Garcia-Cardena, S. Tullius

    Transplant Surgery Research Lab, Harvard Medical School, Brigham and Women's Hospital, Boston, MA; Laboratory for Systems Biology, Center for Excellence in Vascular Biology, Harvard Medical School, Brigham and Women's Hospital, Boston, MA; Renal Division, Harvard Medical School, Brigham and Women's Hospital, Boston, MA; Université Paris Descartes, Sorbonne Paris Cité, Paris, France

    Background. The impact of flow cessation on proximal tubular cell homeostasis and glomerulotubular balance is of clinical significance during renal ischemia and organ preservation. Consequences…
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