ATC Abstracts

American Transplant Congress abstracts

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  • 2013 American Transplant Congress

    Alpha 1-Antitrypsin (A1AT) Prevents Pulmonary Ischemia Reperfusion Injury in Rats

    J. Zhao, W. Gao, M. Cypel, S. Keshavjee, M. Liu

    Latner Thoracic Surgery Research Laboratories, University Health Network Toronto General Research Institute, Toronto, ON, Canada; Department of Thoracic Surgery, Tangdu Hospital, Forth Military Medical University, Xi'an, Shaanxi, China; Department of Surgery, University of Toronto, Toronto, ON, Canada

    Purpose: Even though lung transplantation has been the effective treatment for patients with end-stage lung diseases, pulmonary ischemia reperfusion (IR) injury continues to be the…
  • 2013 American Transplant Congress

    Conversion from Calcineurin Inhibitors to Everolimus Resulted in Decrease of Serum TGF-beta and Urinary NGAL in Renal Transplant Recipients

    N. Alpay, A. Ozkok, Y. Caliskan, T. Akagun, S. Cinar, G. Deniz, M. Sariyar, A. Yildiz

    Internal Medicine Nephrology Department, Istanbul University Istanbul Medical Faculty, Istanbul, Turkey; Internal Medicine Nephrology Department, Medeniyet University, Istanbul, Turkey; Internal Medicine Nephrology Department, Giresun University, Giresun, Turkey; Institute of Experimental Medical Research, Istanbul University, Istanbul, Turkey; General Surgery Renal Transplantation, Medicana International Hospital, Istanbul, Turkey

    Background and Aim: Calcineurin inhibitor (CNI) treatment has been implicated for chronic allograft dysfunction in renal transplant recipients. We aimed to investigate the effects of…
  • 2013 American Transplant Congress

    Comparison of Pharmacokinetics of Once- and Twice-Daily Tacrolimus in Pediatric Kidney Transplant Recipients

    S. Shishido, Y. Hyoudo, H. Nihei, Y. Hamasaki, M. Muramatsu, Y. Niitsu, T. Kawamura, K. Sakai, A. Aikawa

    Pediatric Nephrology, Toho University, Faculty of Medicine, Tokyo, Japan; Nephrology, Toho University, Faculty of Medicine, Tokyo, Japan

    Aims: Few data is available regarding the pharmacokinetic (Pk) profile of newly developed modified-release once-daily formulation of tacrolimus (MR-Tac) in children. This study investigated Pk…
  • 2013 American Transplant Congress

    TIMP-1 Deficiency Promotes p53 Pathway and Impairs Hepatocyte Proliferation in Liver Ischemia Reperfusion Injury

    S. Duarte, H. Kato, M. Ho, R. Busuttil, A. Coito

    Dumont-UCLA Transplant Center, Los Angeles

    Hepatic ischemia/reperfusion injury (IRI) remains a challenge in organ transplantation. Tissue inhibitor of metalloproteinases-1 (TIMP-1) is the major endogenous regulator of matrix metalloproteinase-9 (MMP-9). While…
  • 2013 American Transplant Congress

    Role of Deletion of Donor-Reactive T Cells in Maintaining Human Allograft Tolerance Achieved via Combined Kidney and Bone Marrow Transplantation (CKBMT)

    H. Morris, Y. Shen, T. Kawai, H. Robins, M. Sykes

    Columbia University Medical Center, New York, NY; Fred Hutchinson Cancer Research Center, Seattle, WA; Massachusetts General Hospital, Boston, MA

    BACKGROUND: The need for tolerance protocols in organ transplantation is underscored by the morbidity associated with chronic immunosuppressant use and the inability to prevent chronic…
  • 2013 American Transplant Congress

    Predictors of Fibrosing Cholestatic Hepatitis Development Following Liver Transplantation: Potential Impact on Donor Selection and CMV Prophylaxis

    C. Yazici, C. Jacobs, W. Ahrens, P. Zamor, P. Schmeltzer, V. Casingal, L. Eskind, D. Levi, D. Hayes, M. Russo

    Center for Liver Diseases, Carolinas Medical Center, Charlotte, NC

    Introduction: Fibrosing cholestatic hepatitis (FCH) is an aggressive form of hepatitis C which is seen following liver transplantation (OLT) and it carries high mortality rate.…
  • 2013 American Transplant Congress

    Deficiencies in Patients' Transplant Knowledge and Learning Activities Predicts Longer Time To Complete Kidney Transplant Evaluation

    M. Freeman, J. Pleis, R. Shapiro, L. Myaskovsky

    University of Pittsburgh School of Medicine, Pittsburgh, PA; University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA

    African-American (AA) end-stage kidney disease (ESKD) patients experience several disparities in kidney transplantation (KT), including an increased time to complete transplant evaluation, as compared to…
  • 2013 American Transplant Congress

    Normative Values for Transplant Health-Related Quality of Life

    D. Radosevich, L. McHugh, H. Doan, R. Bailey, G. Cordner, L. Kathryn, M. Hertz, A. Matas, J. Lake, R. Kandaswamy, M. Colvin-Adams, T. Pruett

    Department of Surgery, University of Minnesota, Minneapolis, MN; Center for Lung Science and Health Medical Director, University of Minnesota, Minneapolis, MN; Department of Medicine, Cardiovascular Division, University of Minnesota, Minneapolis, MN; Transplant Information Services, Fairview Health Services, Minneapolis, MN

    Background. Health-related quality of life (HRQoL) evaluates health from the view point of the individual and preferences the “quality of live versus the quantity of…
  • 2013 American Transplant Congress

    False Hepatitis C Antibody Development in Left Ventricular Assist Device Recipients Who Proceed to Heart Transplantation

    D. Lee, D. Levy, J. Shuter, G. Minamoto, D. Goldstein, D. D'Alessandro, V. Muggia

    Medicine, Division of Infectious Disease, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY; Cardiovascular and Thoracic Surgery, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY

    Purpose: Ventricular assist devices (VAD) have been shown to lead to immune activation and higher frequencies of autoantibodies. Previous research reports a rate of 30%…
  • 2013 American Transplant Congress

    Altered Serum miR-326 and miR-142-3p Profiles during Acute Rejection after Heart Transplantation

    I. Dewi, K. Torngren, O. Gidlöf, B. Kornhall, J. Öhman

    Department of Cardiology, Lund University, Lund, Sweden; Clinic of Heart Failure and Valvular Disease, Skåne University Hospital, Lund, Sweden

    IntroductionCirculating miRNAs may serve the purpose as practicable non-invasive biological marker of allograft status in heart transplanted patients, as they can be detected in serum…
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