ATC Abstracts

American Transplant Congress abstracts

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  • 2013 American Transplant Congress

    Maintaining a Calcineurin-Inhibitor after the Diagnosis of PTLD Is Safe and Improves Renal Graft Survival

    E. Morelon, J. Serre, D. Michonneau, E. Bachy, L. Noel, H. Kreis, C. Legendre, M. Mamzer, O. Thaunat

    Renal Transplantation and Immunology, Hospices Civils de Lyon, Lyon, France; Renal Transplantation, APHP, Paris, France; Hematology, Hospices Civils de Lyon, Lyon, France; Pathology, APHP, Paris, France

    Post transplant lymphoproliferative disorder (PTLD) is the second most frequent neoplasia after renal transplantation. This life threatening disease corresponds to an uncontrolled proliferation of lymphocytes…
  • 2013 American Transplant Congress

    ABO Antibody Removal of Plasmapheresis (PP) with Intravenous Immunoglobulin (IVIG) before ABO-Incompatible (ABOI) Kidney Transplantation

    D. Lee, B. Kim, J. Kim

    Medicine, Maryknoll General Hospital, Busan, Republic of Korea; Laboratory Medicine, Maryknoll General Hospital, Busan, Republic of Korea; Surgeon, Maryknoll General Hospital, Busan, Republic of Korea

    Background: ABOI kidney transplantation is an inevitable option to overcome organ shortage. Outcome of ABOI grafts improved and became equivalent to compatible grafts. There were…
  • 2013 American Transplant Congress

    Alpha 1-Antitrypsin (A1AT) Prevents Pulmonary Ischemia Reperfusion Injury in Rats

    J. Zhao, W. Gao, M. Cypel, S. Keshavjee, M. Liu

    Latner Thoracic Surgery Research Laboratories, University Health Network Toronto General Research Institute, Toronto, ON, Canada; Department of Thoracic Surgery, Tangdu Hospital, Forth Military Medical University, Xi'an, Shaanxi, China; Department of Surgery, University of Toronto, Toronto, ON, Canada

    Purpose: Even though lung transplantation has been the effective treatment for patients with end-stage lung diseases, pulmonary ischemia reperfusion (IR) injury continues to be the…
  • 2013 American Transplant Congress

    Conversion from Calcineurin Inhibitors to Everolimus Resulted in Decrease of Serum TGF-beta and Urinary NGAL in Renal Transplant Recipients

    N. Alpay, A. Ozkok, Y. Caliskan, T. Akagun, S. Cinar, G. Deniz, M. Sariyar, A. Yildiz

    Internal Medicine Nephrology Department, Istanbul University Istanbul Medical Faculty, Istanbul, Turkey; Internal Medicine Nephrology Department, Medeniyet University, Istanbul, Turkey; Internal Medicine Nephrology Department, Giresun University, Giresun, Turkey; Institute of Experimental Medical Research, Istanbul University, Istanbul, Turkey; General Surgery Renal Transplantation, Medicana International Hospital, Istanbul, Turkey

    Background and Aim: Calcineurin inhibitor (CNI) treatment has been implicated for chronic allograft dysfunction in renal transplant recipients. We aimed to investigate the effects of…
  • 2013 American Transplant Congress

    Comparison of Pharmacokinetics of Once- and Twice-Daily Tacrolimus in Pediatric Kidney Transplant Recipients

    S. Shishido, Y. Hyoudo, H. Nihei, Y. Hamasaki, M. Muramatsu, Y. Niitsu, T. Kawamura, K. Sakai, A. Aikawa

    Pediatric Nephrology, Toho University, Faculty of Medicine, Tokyo, Japan; Nephrology, Toho University, Faculty of Medicine, Tokyo, Japan

    Aims: Few data is available regarding the pharmacokinetic (Pk) profile of newly developed modified-release once-daily formulation of tacrolimus (MR-Tac) in children. This study investigated Pk…
  • 2013 American Transplant Congress

    TIMP-1 Deficiency Promotes p53 Pathway and Impairs Hepatocyte Proliferation in Liver Ischemia Reperfusion Injury

    S. Duarte, H. Kato, M. Ho, R. Busuttil, A. Coito

    Dumont-UCLA Transplant Center, Los Angeles

    Hepatic ischemia/reperfusion injury (IRI) remains a challenge in organ transplantation. Tissue inhibitor of metalloproteinases-1 (TIMP-1) is the major endogenous regulator of matrix metalloproteinase-9 (MMP-9). While…
  • 2013 American Transplant Congress

    Role of Deletion of Donor-Reactive T Cells in Maintaining Human Allograft Tolerance Achieved via Combined Kidney and Bone Marrow Transplantation (CKBMT)

    H. Morris, Y. Shen, T. Kawai, H. Robins, M. Sykes

    Columbia University Medical Center, New York, NY; Fred Hutchinson Cancer Research Center, Seattle, WA; Massachusetts General Hospital, Boston, MA

    BACKGROUND: The need for tolerance protocols in organ transplantation is underscored by the morbidity associated with chronic immunosuppressant use and the inability to prevent chronic…
  • 2013 American Transplant Congress

    Predictors of Fibrosing Cholestatic Hepatitis Development Following Liver Transplantation: Potential Impact on Donor Selection and CMV Prophylaxis

    C. Yazici, C. Jacobs, W. Ahrens, P. Zamor, P. Schmeltzer, V. Casingal, L. Eskind, D. Levi, D. Hayes, M. Russo

    Center for Liver Diseases, Carolinas Medical Center, Charlotte, NC

    Introduction: Fibrosing cholestatic hepatitis (FCH) is an aggressive form of hepatitis C which is seen following liver transplantation (OLT) and it carries high mortality rate.…
  • 2013 American Transplant Congress

    Deficiencies in Patients' Transplant Knowledge and Learning Activities Predicts Longer Time To Complete Kidney Transplant Evaluation

    M. Freeman, J. Pleis, R. Shapiro, L. Myaskovsky

    University of Pittsburgh School of Medicine, Pittsburgh, PA; University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA

    African-American (AA) end-stage kidney disease (ESKD) patients experience several disparities in kidney transplantation (KT), including an increased time to complete transplant evaluation, as compared to…
  • 2013 American Transplant Congress

    Increased Expression of CTLA-4 and PD-1 and Restricted Functionality as Typical Features of Varizella Zoster Specific T Cells in Patients with Acute Herpes Zoster

    D. Schub, E. Janssen, U. Sester, M. Sester, T. Schmidt

    Transplant and Infection Immunology, Saarland University; Department of Dermatology, ; Internal Medicine IV, Saarland University, Homburg, Saarland, Germany

    Varicella zoster virus (VZV) establishes lifelong persistence and immunocompromised patients such as hemodialysis and transplant recipients are at high risk for virus reactivation presenting as…
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