ATC Abstracts

American Transplant Congress abstracts

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  • 2013 American Transplant Congress

    Overcoming Hyperacute Rejection of Monkey ABO-Incompatible Renal Transplantation Using a Complement Inhibition-Based Strategy

    G. Chen, J. Wang, S. Zhong, S. Chen, X. Wang, L. Wang, Y. Xiang, S. Chen

    Institue of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

    Background: It has been demonstrated that complement inhibition-based strategy enables renal allograft accommodation and long-term engraftment in donor skin-presensitized monkeys. The effect of the same…
  • 2013 American Transplant Congress

    CD3 Antibody-Induced Transplant Tolerance Relies on In Situ TGF-Beta and PD-1 Signaling in T Cells

    M. Baas, A. Besançon, C. Kuhn, C. Mangez, F. Valette, T. Goncalves, L. Chatenoud, S. You

    Unit U1013, INSERM, Paris, France; University Paris Descartes, Paris, France; Department of Nephrology, Radboud University Medical Centre, Nijmegen, Netherlands

    CD3 antibody therapy, successfully used to treat patients with recent onset type 1 diabetes, can restore self-tolerance to autoantigens. We extented these tolerogenic properties to…
  • 2013 American Transplant Congress

    Pretransplant Donor-Specific HLA-Cw Antibodies and Risk of Antibody-Mediated Rejection

    M. Bories, O. Aubert, C. Suberbielle, A. Loupy, F. Martinez, D. Anglicheau, R. Snanoudj, M. Timsit, D. Charron, C. Legendre, R. Sberro Soussan

    Department of Kidney Transplantation, Necker Hospital, Paris, France; Department of Immunology and Histocompatibility, Saint-Louis Hospital, Paris, France; Department of Urology, Georges Pompidou European Hospital, Paris, France

    Donor-specific anti-HLA antibodies (DSA) cause acute and chronic antibody-mediated rejection (AMR) and significantly compromise allograft survival. Clinical relevance of antiHLA-Cw antibodies is still unclear with…
  • 2013 American Transplant Congress

    Renal Graft Survival Post Thoracic and Abdominal Transplant: A Single Center Experience

    R. Nusrat, S. Hariharan, A. Tevar, R. Shapiro, A. Humar, P. Sood

    University of Pittsburgh, Pittsburgh, PA

    Introduction: ESRD is a common complication in patients with non-renal solid organ transplantation and such patients are living longer to receive kidney transplants. There is…
  • 2013 American Transplant Congress

    Is Uric Acid an Independent Risk Factor for Graft Failure in Kidney Transplant Recipients?

    E. Kim, O. Famure, Y. Li, J. Kim

    Multi-Organ Transplant Program, Toronto General Hospital, University of Toronto, Toronto, ON, Canada; Medicine (Nephrology), Toronto General Hospital, University of Toronto, Toronto, ON, Canada

    Background: Hyperuricemia is frequently observed in kidney transplant recipients and it has been implicated in poor allograft function and survival. However, this association remains controversial…
  • 2013 American Transplant Congress

    Liver Retransplantation in HIV-Infected Patients: A Multicenter and Multinational Cohort Study

    M. Gastaca, F. Agüero, S. Peter, G. Paolo, R. Jüergen, A. Kosh, G. Christian, B. Laura Alicia, M. Fernando, M. Marta, R. Antonio, M. Jose, the FIPSE/NIH HIVTR/NEAT023 Investigators

    Cruces University Hospital, Bilbao, Spain; Hosp. Clinic-IDIBAPS. Univ. of Barcelona, Barcelona, Spain; University of California, San Francisco, CA; University of Insubria, Circolo Hospital and Macchi Foundation, Varese, Italy; University of Bonn, Bonn, Germany; King's College Hospital Foundation Trust/King's Health Partners, London, United Kingdom; Clinica Luganese, Lugano, Switzerland; Hospital Italiano, Buenos Aires, Argentina; Hosp. Curry Cabral, Lisbon, Portugal

    We describe the indications, clinical characteristics, and outcome of liver retransplantation (reLT) in HIV-infected patients included in 8 prospective national cohorts.Methods: We analyzed data from…
  • 2013 American Transplant Congress

    Reduction in Mycophenolate in Leukopenic Renal Transplant Patients Is Not Associated with Worse Transplant Outcomes at 1 Year and 3 Year Post-Transplant

    M. Kim, A. Chandraker, S. Gabardi

    Brigham and Women's Hospital, Boston, MA; Harvard Medical School, Boston, MA

    Leukopenia is common in renal transplant recipients (RTRs), and is often managed by dose reduction of causative immunosuppressants, which may in turn increase the risk…
  • 2013 American Transplant Congress

    Back to Bladder Drained Pancreas Transplantation Alone: A Single Centre Experience

    M. Maglione, G. Spoletini, S. Mittal, S. Reddy, R. Ploeg, I. Quiroga, A. Vaidya, J. Gilbert, P. Friend, S. Sinha

    Oxford Transplant Centre, University of Oxford, Churchill Hospital, Oxford, United Kingdom; Nuffield Department of Surgical Sciences, University of Oxford, Churchill Hospital, Oxford, United Kingdom

    Controversy remains whether there is still a role for bladder drainage (BD) in pancreas transplantation. Compared to excellent results in simultaneous pancreas kidney transplantation, pancreas…
  • 2013 American Transplant Congress

    Protects Effect of HIF-1α in Ischemia/Reperfusion-Induced Mitochondrial Injury, The

    Y. Guo, L. Feng, Y. Zhou, M. Xia, G. Sun, S. Li, D. Long, Y. Li

    Key Laboratory of Transpalnt Engineering and Immunology, West China Hospital, Chengdu, Sichuan, China

    Background. Ischemia by itself can trigger cell killing, and reperfusion accelerates the process. Many studies have demonstrated that HIF-1Α play an important role in mitochondrial…
  • 2013 American Transplant Congress

    Utility of Six-Minute Walk Distance in Predicting Waitlist Mortality for Lung Transplant Candidates, The

    A. Castleberry, B. Englum, L. Snyder, M. Worni, A. Osho, R. Pietrobon, S. Palmer, R. Davis, M. Hartwig

    Duke University Medical Center, Durham, NC

    Six-minute walk distance (6MWD) dichotomized over/under 150 feet is one of 15 variables included in the Lung Allocation Score (LAS), however the independent association of…
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