2013 American Transplant Congress
Prolonged Cold Ischemia Increases the Early Infiltration and Effector Functions of Memory CD8 T Lymphocytes in Cardiac Allografts
Immunology, Cleveland Clinic, Cleveland, OH
Introduction: During organ transplantation, ischemia-reperfusion injury (IRI) is an inescapable challenge that detrimentally impacts graft outcome. While I/R induced molecular mechanisms mediating injury of ischemic…2013 American Transplant Congress
Impact of HLA-DQ Matching on Alloantibody Production in Primary Renal Transplant Recipients, The
Recent findings have shown the DQ donor specific alloantibodies (DSA) are associated with transplant glomerulopathy and seem to appear more often than other loci DSA.…2013 American Transplant Congress
Early Steroid Avoidance Reduces the Chance for a Subsequent Transplant in Renal Transplant Recipients with Graft Failure
Early steroid avoidance (SA) in renal transplantation has been associated with more acute rejections compared to steroid continuation (SC) protocols. After graft failure, the long…2013 American Transplant Congress
Is There a Clinically Meaningful Difference between "Preformed" and "De Novo" Alloantibodies in Negative Crossmatch Renal Transplantation?
Researchers have long categorized DSA into 2 types: preformed and de novo. However, there have been no studies that directly compare the 2 entities. Herein,…2013 American Transplant Congress
Novel Population of Bone Marrow-Derived Granulocytes Express FasL and Perforin and Mediate Early Ischemic Injury, A
Immunology, Cleveland Clinic, Cleveland, OH
Introduction: Recent studies from our laboratory have documented a novel population of bone marrow derived granulocytes which are induced upon skin inflammation and are required…2013 American Transplant Congress
Tighter Pretransplant Glycemic Control Is Associated with Reduced Cardiovascular Events after Kidney Transplant in Diabetic Patients at 5 and 10 Year Follow-Up
University of Cincinnati, Cincinnati
Data on the impact of pretransplant glycemic control on posttransplant cardiovascular (CV) outcome and survival is limited and inconsistent. We hypothesized that tighter glycemic control…2013 American Transplant Congress
Requirement for T Cell Intrinsic MyD88 for Treg Homeostasis in Transplantation
The TLR-MyD88 signaling pathway enables the innate immune system to sense inflammation and promote adaptive immune responses. TLRs are expressed on T cells as well,…2013 American Transplant Congress
First Year Mild Renal Insufficiency Associated with Increased Mortality after Heart Transplant
Cedars-Sinai Heart Institute, Los Angeles, CA
BACKGROUND: Renal failure has been a consistent risk factor for mortality after heart transplantation. From the ISHLT Registry approximately one third of patients have an…2013 American Transplant Congress
Deceased Kidney Donor Acute Tubular Necrosis and the Development of Delayed Graft Function
Background: Acute kidney injury (AKI) in the donor kidney may contribute to delayed graft function (DGF), heightened immunologic risk, and progressive graft fibrosis, thereby affecting…2013 American Transplant Congress
Outcomes Following Positive Crossmatch Renal Transplantation Despite Failure To Convert to Negative Flow Crossmatch after Desensitization
Purpose: Determine outcomes of positive crossmatch (PXM) renal transplant recipients that failed to convert to negative flow cytometry crossmatch (FCXM) despite desensitization.Methods: All patients that…
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