2013 American Transplant Congress
Endodermal Precursor Cells Derived from Embryonic Stem Cells Can Engraft in Mouse Liver
Surgery, University of Florida, Gainesville, FL
Purpose: Embryonic stem (ES) cells have been shown to have great value therapeutically due to their limitless capacity for self-renewal and proliferation, and their ability…2013 American Transplant Congress
Determinants of Late Acute Rejection in Pediatric & Adolescent Kidney Transplant Recipients
Pediatric Nephrology, Children's National Medical Center, Washington, DC
Background: Long-term graft function has not kept pace with short-term graft survival in children. Late Acute Rejection (LAR) episodes are in part responsible for the…2013 American Transplant Congress
Immune Cell Derived C3a and C5a Mediate Human Alloreactive T Cell Immunity
Renal Division, Department of Medicine, Mount Sinai School of Medicine, New York, NY
Background: Murine studies showed immune cell derived C3a/C5a are costimulatory intermediaries required for T cell activation. We investigated how these concepts apply to human alloreactive…2013 American Transplant Congress
Nonmyeloablative Conditioning Regimen with B Cell Depletion and Long-Term Outcome of HLA Mismatched Combined Kidney and Bone Marrow Transplantation without Maintenance Immunosuppression
Background: We report the long-term results (up to 10 years) of one-haplotype HLA mismatched kidney transplantation without maintenance immunosuppression (IS) following combined kidney and bone…2013 American Transplant Congress
Role of Eosinophils in the Induction and Maintenance of the Alloantibody Response, The
Department of Medicine, Mount Sinai School of Medicine, New York
Background: Delineating mechanisms of alloantibody formation and maintenance could guide development of novel therapies aimed at treating antibody mediated transplant rejection. Published work from 2011…2013 American Transplant Congress
Factors Implicated in the Expression of Selenium Binding Protein 1 in Chronic Allograft Vasculopathy
Background: Selenium binding protein-1 (SBP-1) has been implicated in intracellular protein trafficking and secretion. In a rhesus monkey kidney transplant model we previously demonstrated that…2013 American Transplant Congress
Spectrum of Renal Pathology and Gene Expression Profiles of Kidney Biopsies in Patients with Cirrhosis Listed for Liver Transplantation
Transplantation, Montefiore Medical Center, Bronx, NY
Introduction: We previously demonstrated universal glomerular abnormalities in kidney biopsies after orthotopic liver transplantation (OLT). We hypothesize that these changes exist prior to OLT and…2013 American Transplant Congress
Where Are the Real Barriers in Post Mortem Organ Donation?
Low organ donation rate from deceased donors (DD) is believed to result from the societal misperception and non-acceptance of brain death.However, it has been shown…2013 American Transplant Congress
Unique Role of Antibodies to MHC Class I in the Induction of Inflammatory Cellular Infiltration: Selective Role for CD4 and CD8 Cells in Development of Autoimmunity and Obliterative Airway Disease
Surgery, Pathology & Immunology, Washington University School of Medicine, St. Louis, MO
Background: Anti-MHC class I administration into lungs results in cellular infiltration, epithelial damage, immune responses to lung associated self-antigens(SAgs), KΑ1 tubulin (KΑ1T) and Collagen V…2013 American Transplant Congress
IL-2 Antagonist Induction Therapy Preserves Renal Function in Liver Transplant Recipients
Pharmacy, MUSC, Charleston, SC; Transplant, MUSC, Charleston, SC
Background: Studies have produced varying results regarding whether IL-2 antagonist induction improves outcomes, including renal function and patient and graft survival in liver transplantation. This…
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