2013 American Transplant Congress
Multicenter Valdiation of Urinary Biomarkers in Kidney Transplantation: Urinary CXCL9 Protein Correlates with Acute Rejection and Deterioration of Kidney Function
Noninvasive biomarkers to diagnose and/or predict outcomes in kidney transplant recipients are needed to assess post-transplant risk and ultimately to guide management of immunosuppression. Results…2013 American Transplant Congress
Peri-Transplant Absolute Lymphocyte Count Is a Reliable Predictive Factor for Advanced Recurrence of Hepatitis C Following Liver Transplantation
Aim: Lymphocytes play an active role in immunity against HCV. The aim of this study was to investigate the impact of peri-transplant absolute lymphocyte counts…2013 American Transplant Congress
Long-Range, CIS-Regulatory Architecture of the IL-2 and IL-21 Multi-Locus Region
IL-2 is a crucial cytokine with roles in both immunity and tolerance, and IL-21 mediates inflammation by promoting B cell and CTL differentiation. These cytokines…2013 American Transplant Congress
Antibodies to K-α1 Tubulin and IL 17 Induces Periostin Dependent Pro-Fibrotic Signaling Cascades: A Novel Biomarker Involved in the Pathogenesis of Chronic Lung Allograft Rejection
Surgery, Medicine, Pathology & Immunology, Washington University School of Medicine, St. Louis, MO
Background: Antibodies (Abs) to K-Α1-tubulin (KΑ1T), an epithelial gap junction cytoskeletal protein, and Interleukin (IL)-17, have been implicated in the pathogenesis of bronchiolitis obliterans syndrome…2013 American Transplant Congress
Impact of Donor Age on Three-Year Outcomes in Recipients of Extended Criteria Kidneys Treated with Belatacept vs Cyclosporine in BENEFIT-EXT Trial
Introduction: Belatacept (bela) was associated with improved renal function & similar pt/graft survival & AR rates vs CsA through 3 yrs follow-up in BENEFIT-EXT, the…2013 American Transplant Congress
Outcomes at Five Years in Black/African-American Kidney Transplant Recipients from the Long-Term Extension of the Belatacept BENEFIT and BENEFIT-EXT Studies
Introduction: Previously reported long-term results of BENEFIT & BENEFIT-EXT demonstrated a consistent safety profile & sustained improvement in renal function vs CsA over time. Here…2013 American Transplant Congress
Role of Foxp3 for Augmented Homeostatic Proliferation of Treg, The
Thomas E. Starzl Transplantation Institute, Pittsburgh, PA
CD4+Foxp3+ Tregs play a critical role in transplant tolerance. Foxp3 does not initiate thymic differentiation of natural Treg (nTreg), but is essential for later differentiation…2013 American Transplant Congress
Circulating MicroRNAs Correlate with Diabetic Nephropathy and Systemic Microvascular Damage and Normalize after Simultaneous Pancreas-Kidney Transplantation
Aim: Simultaneous pancreas-kidney transplantation (SPK) is an advanced treatment option for patients with type I diabetes with extensive microvascular disease and nephropathy (DN). Circulating microRNAs…2013 American Transplant Congress
Irradiation and T Cell Depletion Augment Bone Marrow-Derived Chimerism at the Cost of Morbidity and Mortality in a Non-Human Primate Model of Vascularized Composite Allotransplantation
PurposeWe have shown that vascularized bone marrow (VBM) prolongs vascularized composite allograft survival in nonhuman primates (NHP). To explore the potential for chimerism and tolerance,…2013 American Transplant Congress
Liver Transplant for NASH: We Need To Spare the Nephron!
Pharmacy, MUSC, Charleston, SC; Transplant, MUSC, Charleston, SC
Background: The aim of this study was to evaluate outcomes of patients transplanted for NASH cirrhosis compared to those without NASH.Methods: Single center retrospective longitudinal…
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