2013 American Transplant Congress
Prospective and Randomized Trial Comparing Tacrolimus Versus Sirolimus after Simultaneous Pancreas-Kidney Transplantation
Institut de Transplantation-Urologie-Néphrologie, Nantes University Hospital, Nantes, France
Introduction. Minimizing or sparing potentially nephrotoxic and diabetogenic immunosuppressants could represent an advantage following simultaneous pancreas-kidney transplantation (SPK-Tx).Purpose. We report here the actual one-year result…2013 American Transplant Congress
Variability of IMPDH-Activity in Long-Term MPA Mediated Immunosuppression
Purpose of this study was to examine wether the long term exposure for mycophenolate mofetil (MMF) or enteric coated form (EC-MPS) is leading to an…2013 American Transplant Congress
Suppression of Acute Rejection by Administration of Prostaglandin E2 Receptor Subtype 4 (EP4) Agonist in a Rat Heterotopic Small Bowel Transplantation Model
Background: Prostaglandin E2 (PGE2)–PGE2 receptor subtype 4 (EP4) signaling is known to modulate the inflammation process. Several studies have demonstrated the potential utility of EP4-selective…2013 American Transplant Congress
Kidney Injury Molecule-1 and Osteopontin: New Markers for Prediction of Early Kidney Transplant Rejection
Background. Kidney injury molecule-1 (KIM-1) and osteopontin (OPN) play important roles in immune regulation. We hypothesized that serum KIM-1 and OPN might serve as biomarkers…2013 American Transplant Congress
Health-Related Quality of Life and Adherence to Medication in Kidney Transplantation: A Longitudinal Analysis
AimTo analyse the influence of dialysis type on adherence to immunosupressive medications (IS) and HRQoL before and after KT.Material and Methods. Between years 2004-2008 156…2013 American Transplant Congress
Impact of Vitamin D, Bisphosphonate, and Combination Therapy on Bone Mineral Density in Kidney Transplant Patients
Background: Osteoporosis can develop and become aggravated in a large number of kidney transplant patients; however, the best preventive options for post-transplant osteoporosis remain controversial.Methods:…2013 American Transplant Congress
Immune Suppressant Effect of Erythropoietin Alpha on Human Allo-Reactive T Cell Responses
Renal Division, Department of Medicine, Mount Sinai, New York
Recent clinical studies showed that complete correction of anemia with erythropoietin (EPO) therapy improves human kidney transplant outcomes, but mechanisms underlying this protective effect are…2013 American Transplant Congress
Defining pp65 Enemia and qPCR Cut-Offs for Pre-Emptive Therapy of CMV Disease in Low-Risk, Seropositive Renal Transplanted Recipients
Renal Transplant Service, University of São Paulo School of Medicine, Sao Paulo, Brazil
CMV disease mostly invasive gastro-intestinal with low viremia occurs in approximately 16% of CMV seropositive renal transplant recipients not receiving Thymoglobuline (ATG). Pre-emptive therapy (PETh)…2013 American Transplant Congress
2B4 Induced by Selective CD28 Blockade Functionally Regulates Alloreactive Memory CD8+ T Cell Responses
Emory Transplant Center, Emory University, Atlanta, GA; Bristol-Myers Squibb, Princeton, NJ
Studies in both murine and NHP models have shown that CTLA-4Ig-resistant rejection is mediated by CD8+ T cells, particularly memory CD8+ T cells. Because CTLA-4…2013 American Transplant Congress
Bone Marrow and Adipose Tissue Derived Mesenchymal Stem Cells Induce HLA-Specific Lysis by CD8+ T Cells
IntroductionMesenchymal Stem Cells (MSC) are an interesting cell therapy for clinical organ transplantation and are usually isolated from bone marrow (BM-MSC) or adipose tissue (A-MSC)…
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