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American Transplant Congress abstracts

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  • 2013 American Transplant Congress

    Hand Transplantation in Its Thirteenth Year: The Innsbruck Clinic Experience

    A. Weissenbacher, G. Pierer, M. Gabl, M. Ninkovic, T. Hautz, B. Zelger, W. Löscher, M. Kumnig, M. Rieger, R. Margreiter, J. Pratschke, G. Brandacher, S. Schneeberger

    Department of Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Innsbruck, Tyrol, Austria; Department of Plastic-, Reconstructive and Aesthetic Surger, Innsbruck Medical University, Innsbruck, Tyrol, Austria; Department of Traumatology, Innsbruck Medical University, Innsbruck, Tyrol, Austria; Institute of Pathology, Innsbruck Medical University, Innsbruck, Tyrol, Austria; Department of Neurology, Innsbruck Medical University, Innsbruck, Tyrol, Austria; Center of Psychiatry and Psychotherapy, Innsbruck Medical University, Innsbruck, Tyrol, Austria; Department of Diagnostic Radiology, Innsbruck Medical University, Innsbruck, Tyrol, Austria

    Introduction: We describe here the outcome after two bilateral hand, one bilateral forearm and one unilateral hand transplantation at 12.5, 9.5, 6.5 and 3.5 years…
  • 2013 American Transplant Congress

    Kidney Transplantation Does Not Reverse the Premature T Cell Ageing in End-Stage Renal Disease Patients

    R. Meijers, N. Litjens, E. de Wit, A. Langerak, C. Baan, W. Weimar, M. Betjes

    Internal Medicine Section Nephrology and Transplantation, Erasmus MC, Rotterdam, Netherlands; Immunology, Erasmus MC, Rotterdam, Netherlands

    Background End-stage renal disease (ESRD) patients have a defective T cell mediated immune system which is related to excessive premature ageing of the T cell…
  • 2013 American Transplant Congress

    Comparison of Transumbilical and Conventional Laparoscopic Donor Nephrectomy

    M. Minz, V. Kaji, A. Sharma, S. Singh, D. Kenwar

    Department of Renal Transplant Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India

    Forty-eight healthy voluntary renal donors between 18 and 60 years of age with BMI less than 30 who were planned for laparoscopic left side donor…
  • 2013 American Transplant Congress

    Liver Transplantation: Do Senescence and Autophagy Modulate the Development of Chronic Pathology

    J. Brain, E. Thompson, D. Jones, A. Burt, J. Kirby

    ICM, Newcastle University, Newcastle upon Tyne, United Kingdom; Clinical Deanery, Newcastle University, Newcastle uon Tyne, United Kingdom

    During the past 20 years there has been a reduction in the incidence of both acute cellular rejection (ACR) and chronic ductopenic rejection following liver…
  • 2013 American Transplant Congress

    Efficacy of Everolimus with Reduced Cyclosporine in Japanese De Novo Renal Transplant Recipients: 24-Month, Randomized, Multicenter Study

    K. Saito, K. Uchida, S. Takahara, N. Yoshimura, S. Teraoka, C. Cornu-Artis, E. Kobayashi, K. Takahashi

    Niigata University, Niigata, Japan; Aichi Medical University, Aichi, Japan; Osaka University, Osaka, Japan; Kyoto Prefectural University of Medicine, Kyoto, Japan; International University of Health and Welfare, Atami Hospital, Shizouka, Japan; Novartis Pharma AG, Basel, Switzerland; Jichi Medical University, Tochigi, Japan

    Introduction: Results from study A1202 showed that everolimus (EVR) plus reduced dose cyclosporine (rCsA) prevents acute rejection, preserves renal function, and reduces incidence of viral…
  • 2013 American Transplant Congress

    Positive Flow Crossmatches in Renal Patients without “Detectable” Anti-Donor HLA Antibodies; Maximizing Renal Transplant Rate by Decreasing False Positive Crossmatches

    R. Cirocco, J. Mendiolina, L. Biondi, M. Moritz

    HLA Laboratory and the Transplant Center, Lehigh Valley Health Network, Allentown, PA

    A recurring problem in recipient selection for deceased donor renal transplantation is a positive crossmatch in a “non-donor antigen sensitized “individuals. We initiated a study…
  • 2013 American Transplant Congress

    IL-33: Friend or Foe?

    D. Abendroth, M. Marzinzig, M. Stangl

    Center of Surgery, University of Ulm, Ulm, Germany; Visceral and Transplant Surgery, Ludwig-Maximilians-University, Munich, Germany

    Introduction We hypothesize that innate inflammatory response either preexistent in the recipient or released by injured allografts during transplantation may influence graft outcome. In a…
  • 2013 American Transplant Congress

    Effects of Everolimus and Tacrolimus Exposure on Efficacy and Renal Function in Liver Transplant Recipients at 24 Months in a Randomized Trial (H2304)

    L. Fischer, G. Kaiser, B. Koneru, L. Toselli, F. Durand, N. Heaton, K. Shetty, G. Dong, P. Lopez, G. Junge, J. Kovarik

    For the H2304 Study Group, Hamburg, Germany; Novartis Pharma AG, Basel, Switzerland

    Purpose: The present analysis aims to explore the effect of everolimus (EVR) and tacrolimus (TAC) exposure on efficacy and safety events of interest in de…
  • 2013 American Transplant Congress

    Everolimus-Facilitated Reduction of Tacrolimus in De Novo Liver Transplant Recipients Achieves Comparable Overall Efficacy with Fewer Biopsy-Proven Acute Rejections Versus Standard Tacrolimus: 24-Month Results of a Randomized Trial

    J. Fung, K. Chavin, Y. Moysyuk, S. Orloff, S. Yantorno, R. Jones, P. Neuhaus, G. Dong, P. Lopez, G. Junge, F. Nevens

    For the H2304 Study Group, Cleveland; Novartis Pharmaceuticals Corporation, New Jersey; Novartis Pharma AG, Basel, Switzerland

    Purpose: The H2304 (NCT00622869) study compared the efficacy and safety of concentration-controlled everolimus (EVR) to eliminate or to reduce tacrolimus (TAC) vs standard TAC (TAC-C)…
  • 2013 American Transplant Congress

    Lack of Clinical Factors Increasing Quantitative Interstitial Fibrosis after Renal Transplantation under a Lower Target Trough Strategy of Tacrolimus

    N. Komine, S. Satoh, K. Numakura, M. Saito, T. Inoue, S. Narita, Y. Miura, N. Tsuchiya, H. Kagaya, M. Miura, T. Habuchi

    Urology, Akita University, Akita, Japan; Division of Renal Replacement Therapeutic Science, Akita University, Akita, Japan; Pharmacy, Akita University, Akita, Japan

    INTRODUCTION AND OBJECTIVES: Chronic allograft injury is a multi-factorial process based on immunologic and non-immunologic factors. Patients with the CYP3A5*3/*3 genotype (non-expressers) require a lower…
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