2013 American Transplant Congress
Oral Ribavirin Therapy for Respiratory Syncytial Virus Infections in Moderately to Severely Immunocompromised Patients
BackgroundRespiratory syncytial virus (RSV) can be fatal in immunocompromised patients. Aerosolized ribavirin is used for treatment but it is costly, teratogenic, and inconvenient. We aimed…2013 American Transplant Congress
Utilization of Kidneys from Donors after Circulatory Death in China: An Initial Report from a Single Center
In 2007, a landmark decision that is supported by the international transplant community, the Chinese national government has established regulations to gradually abolish the use…2013 American Transplant Congress
Outcomes of Switching to Belatacept from a Calcineurin Inhibitor in Kidney Transplant Recipients: 3 Year Results from the Long-Term Extension of a Phase II Study
Introduction: There remains a need for immunosuppressive agents which offer long-term preservation of renal function and an acceptable safety profile in the switch setting. Here…2013 American Transplant Congress
Polyoma BK-Virus-Specific T Cells as a Surrogate Marker for Polyomavirus-Associated Nephropathy after Pediatric Kidney Transplantation
After kidney transplantation (KTx) immunosuppressive therapy causes impaired cellular immune defense resulting in increased risk of polyomavirus-associated nephropathy (PVAN). Prognostic markers for the outcome of…2013 American Transplant Congress
Molecular Markers To Distinguish Modes of Renal Graft Rejection
Renal transplant recipients may suffer serious consequences from graft rejection. We sought to develop an accurate, noninvasive test that can detect and distinguish acute cellular…2013 American Transplant Congress
Role of Commensal Microbiota in Skin Allograft Rejection
Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL
A multitude of recent studies have demonstrated that the intestinal microbiota influences systemic autoimmunity and immune responses to infection. Organs associated with commensal bacteria, including…2013 American Transplant Congress
Time to Presentation of Donor Derived Infection
Background: Differentiating donor-derived infection (DDI) from other causes of illness after solid organ transplantation (SOT) can be challenging. Early recognition of potential DDI allows treatment/prevention…2013 American Transplant Congress
CD40-Dependent Help by CD4 T Cells Is Required for CD8 T Cell Recovery after Antithymocyte Globulin Lymphoablation
The Cleveland Clinic, Cleveland
Antithymocyte globulin (ATG) is a lymphoablative agent used in transplant patients. However, ATG treated recipients eventually reconstitute their T cell repertoire, develop anti-donor immune responses…2013 American Transplant Congress
Significant Impact of Prolonged Brain Death Duration on Patient Survival after Kidney Transplantation
Introduction: In renal transplantation, graft survival using organs from deceased donors is inferior to results after living donation. Little however is known about the effect…2013 American Transplant Congress
Follicular Helper T Cell Modulation by Costimulation Blockade Prevents Antibody-Mediated Rejection in Nonhuman Primate Renal Transplantation
Surgery, Emory University, Atlanta, GA; Pathology, Emory University, Atlanta, GA
[Background] De novo donor-specific antibody (DSA) after organ transplantation promotes antibody-mediated rejection (AMR) and causes late graft loss. Nearly a third of transplant recipients develop…
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