2013 American Transplant Congress
Donation after Circulatory-Death in the UK
Background: The number of deceased donors in the UK has increased from 809 in 2007-8 to 1088 in 2011-2. This increase can be ascribed, predominantly,…2013 American Transplant Congress
YAP Phosphorylation Is Altered during Liver Regeneration in a Rat Hepatectomy Model
Purpose:The transcription factor YAP has been shown to stimulate hepatocyte proliferation. Furthermore, overexpression of YAP results in liver overgrowth leading to transformation into malignancy. Phosphorylation…2013 American Transplant Congress
Blockade of Phagocytosis Accelerates Cardiac Allograft Rejection
Transplantation Research Center, Brigham&Women's Hospital, Boston, MA
Under physiological conditions, prompt clearance of dying cells provides protection from the release of pro-inflammatory contents, induces T cell tolerance to self-antigens and prevents autoimmunity.…2013 American Transplant Congress
Central Role of Mitochondrial Energy Metabolism in Foxp3+ Treg Cell Function and Allograft Survival
Increasing Foxp3+ regulatory T-cell (Treg) numbers and/or their function are innovative approaches to immunosuppression post-transplantation. T-effector (TE) and Treg cells have differing metabolic needs, but…2013 American Transplant Congress
Long-Term Outcomes of Older Adults after Liver Transplantation in the MELD Era
Since 2002, MELD score has been the basis of liver allocation system. Among older adult liver transplant (LT) recipients, short-term outcomes in MELD era were…2013 American Transplant Congress
Influence of Donor’s and Recipent’s CMV Serostatus on the Allograft Survival and CD8 Cell Compartment Evolution in Kidney Transplant Recipient: A Monocentric Cohort Study
Background : Despite the large body of literature, no clear causal relationship between chronic CMV infection of kidney transplants and long-term graft dysfunction has yet…2013 American Transplant Congress
Are Preemptive Deceased Donor Kidney Transplants Equitable?
University of Chicago, Chicago, IL
Background: The UNOS kidney allocation policy has evolved since first introduced in the 1980s. In 2002 there was a reduction in the number of points…2013 American Transplant Congress
Are Some “High-Risk” Renal Transplants Recipients Higher Risk Than Others?
The Methodist Hospital, Houston
In renal transplantation, African Americans (AA), and nonAA sensitized with >20% panel reactive antibodies (PRA) are commonly accepted as “high-risk” for rejection and thus routinely…2013 American Transplant Congress
Noncompliance as a Major Cause of Late Graft Failure in Kidney Transplantation
While many clinical reports exclude mention of patient noncompliance, our experience includes those who often stop and then restart or even completely stop taking their…2013 American Transplant Congress
Higher IL10 Production by Transitional B Cells in Tolerant Kidney Transplant Recipients
Transplantation tolerance reduces the risk of infection, malignancy and cardiovascular disease caused by immunosupresive drugs. Indices of Tolerance revealed that tolerant kidney transplant recipients had…
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