2013 American Transplant Congress
Antibody Targeting the TCR β-Chain Selectively Abrogates Antigen-Specific T Cell Responses by Modulating T Cell Transcriptional Patterns
Medical Microbiology & Immunology, University of Toledo College of Medicine, Toledo, OH
Background: T cells are the master regulators of the immune system and represent critical targets for immune therapies. In this study we aimed to understand…2013 American Transplant Congress
Incidence of Iron Deficiency in Kidney Transplant Candidates Based on the Updated KDIGO Guideline for Anemia, The
Kidney Transplant Program, University of Utah Health Care, Salt Lake City
BACKGROUND: Kidney transplant (tx) candidates often receive iron replacement therapies to manage anemia of CKD. At the time of tx, ongoing iron deficiency may delay…2013 American Transplant Congress
New Evidence for CMV-Associated Polyfunctional T Cells Expressing Both CD57 and PD-1
Emory Transplant Center, Atlanta
In models of chronic viral infection such as HIV, the canonical markers of T cell senescence (CD57) and exhaustion (PD-1) have been assumed to be…2013 American Transplant Congress
New Onset Proteinuria after Conversion to Sirolimus in Renal Transplantation
To avoid nephrotoxicity calcineurin inhibitors are frequently replaced by mTOR-inhibitors like Sirolimus (SRL). Worsening of proteinuria has been reported after conversion to mTOR-inhibitors. We aimed…2013 American Transplant Congress
Nonadherence Related to Psychosocial Issues Predominates in the Majority of Acute Rejections during Early Posttransplant Period
Kidney Transplantation, St. Vincent Hospital, Indianapolis, IN
BACKGROUND: Nonadherence (NA) is a known cause of acute rejection (AR) and graft loss in this modern era of immunosuppression. However, extent of contribution of…2013 American Transplant Congress
Sarcopenia of Cirrhosis Does Not Reverse after Liver Transplantation
Sarcopenia (loss of muscle mass) is common in patients with end stage liver disease (ESLD). Sarcopenia is potentially reversible after liver transplantation (LT) but no…2013 American Transplant Congress
Persistent Asymptomatic C4d Staining in the First-Year after Heart Transplantation Is a Marker for Cardiac Allograft Vasculopathy
Cedars-Sinai Heart Institute, Los Angeles, CA
BACKGROUND: Antibody-mediated rejection (AMR) after heart transplantation has recently been defined as a pathological diagnosis. This would include immunopathology which includes C4d staining and histologic…2013 American Transplant Congress
Extended Criteria Donor (ECD) Renal Allograft Use in Older Recipients in a Short Wait Time Center: Is There an Advantage?
Surgery, Univeristy of Florida, Gainesville, FL; Medicine, Univeristy of Florida, Gainesville, FL
Merion et al. (JAMA, 2005) concluded that ECD renal grafts benefit a recipient if they are older than 40 with hypertension or diabetes, and have…2013 American Transplant Congress
TOL101 Signaling Pathways, a Novel CD3 Independent T Cell Inactivation & Treg Induction Cascade
In a Phase 2 renal transplant study, the anti-ΑΒ TCR antibody TOL101 inhibited T cell function in transplant patients at a range of doses. When…2013 American Transplant Congress
Living Donor Kidney Transplantation in the Pediatric Population: Risk Factors for Adverse Outcomes
Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Purpose: To review the pediatric recipients of laparoscopic donor nephrectomy (LDN) at our institution and examine predictors of adverse outcomes, particularly in patients ≤5 years…
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