ATC Abstracts

American Transplant Congress abstracts

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  • 2013 American Transplant Congress

    Impact of Donor Hypoxemia and Hypotension in DCD Liver Transplantation

    K. Kishiyama, R. Girlanda, C. Desai, K. Shetty, J. Laurin, R. Satoskar, E. Island, C. Matsumoto, T. Fishbein

    Medstar Georgetown University Hospital, Washington, DC

    Aim: Donation after cardiac death (DCD) is a valuable source of liver grafts Little is known about the impact of severe hypoxemia and hypotension before…
  • 2013 American Transplant Congress

    Understanding Racial Disparity in Living Donor Kidney Transplantation

    R. Garcia-Roca, N. Choudhury, I. Tzvetanov, H. Jeon, J. Oberholzer, E. Benedetti

    Division of Transplantation, University of Illinois at Chicago, CHicago, IL

    BACKGROUND: There is a large ethnical disparity in the rate of living kidney donation. We analyzed possible causes of this difference.METHOD: We performed a single-center…
  • 2013 American Transplant Congress

    Levels of IL-33 and Soluble IL-33 Receptor (sST2) Distinguish Acute Rejection from Enteritis in Small Bowel Transplant Recipients

    R. Fischer, L. Mathews, Y. Sun, D. Mercer, H. Turnquist

    Pediatric Gastroenterology, Children's Mercy Hospital, Kansas City, MO; Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA; Surgery, Transplantation, University of Nebraska Medical Center, Omaha, NE; Surgery and Immunology, Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA

    BackgroundIL-33 is a member of the IL-1 cytokine family with functions ascribed to its actions on immune cells expressing the IL-33 receptor, ST2. Following heart…
  • 2013 American Transplant Congress

    Incorporating Time from Donation (TFD) to the MDRD and CKD-EPI Formulas Enhances Their Performance in Kidney Donors

    H. Ibrahim, S. Jackson, A. Matas, N. Issa, R. Spong, A. Kukla

    Department of Medicine, University of Minnesota, Minneapolis, MN; Surgery, University of Minnesota, Minneapolis, MN

    Introduction:The reexpressed MDRD study equation is least biased in estimating GFR in former kidney donors. Hyperfiltration is not limited to the first year after donation.…
  • 2013 American Transplant Congress

    In Vivo Interaction between ATG and IVIg May Decrease the Efficacy of Antibody Mediated Rejection Treatment

    C. Kuriakose, P. Warner, K. Nelson, N. Kieran, R. Bakthavatsalam, C. Davis, N. Leca

    Division of Nephrology, University of Washington, Seattle; Puget Sound Blood Center, Seattle; Division of Transplant Surgery, University of Washington, Seattle

    Treatment of antibody mediated rejection(AMR) is not standardized. Anti-thymocyte globulin(ATG) is commonly used in combination with intravenous immunoglobulin(IVIg) and plasmapheresis(Px). Our in vitro data show…
  • 2013 American Transplant Congress

    New OPTN Requirement for DNA-Based HLA Typing for Deceased Donors: Initial Results Show Increased Typing Resolution for Improving Virtual Crossmatches, A

    L. Baxter-Lowe, A. Kucheryavaya, N. Reinsmoen

    UCSF, San Francisco, CA; UNOS, Richmond, VA; Cedars-Sinai, Los Angeles, CA

    Historically HLA typing of deceased donors was performed using serological or DNA-based methods. On 6/1/11, the Organ Procurement and Transplantation Network (OPTN) implemented a new…
  • 2013 American Transplant Congress

    Association of B Cell Population in Splenic Histology of ABO Incompatible Kidney Transplantation and One-Year Graft and Recipient Survival, The

    I. Tzvetanov, L. Bejarano-Pineda, S. Setty, A. Harbhajanka, A. Khan, H. Jeon, R. Garcia-Roca, J. Oberholzer, E. Benedetti

    Department of Surgery, University of Illinois Hospital & Health Sciences System, Chicago, IL; Department of Pathology, Illinois Hospital & Health Sciences System, Chicago, IL

    Purpose: To evaluate the association of plasma cell population (PCs) in splenic histology of ABO incompatible (ABO-i) kidney transplant recipients and one year graft and…
  • 2013 American Transplant Congress

    IRF-1 Regulates Immune Reactivity in Mouse Hepatic Allografts

    S. Kimura, O. Yoshida, J. Klune, S. Yokota, K. Ozaki, N. Murase, A. Thomson, D. Geller

    University of Pittsburgh, School of Medicine, Thomas E. Starzl Transplantation Institute, Pittsburgh, PA

    Introduction: We have shown previously that Interferon Regulatory factor-1 (IRF-1) contributes to liver I/R injury by activating proinflammatory genes, but its role in host responses…
  • 2013 American Transplant Congress

    Ex Vivo-Expanded Non-Human Primate Regulatory T Cells Are Resistant to Alemtuzumab-Mediated, Complement-Dependent Cytotoxicity

    E. Dons, G. Raimondi, H. Zhang, J. Bhama, L. Tu, M. Ezzelarab, J. IJzermans, D. Cooper, A. Thomson

    Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA; Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, PA; Surgery, Erasmus Medical Center Rotterdam, Rotterdam, Netherlands; Immunology, University of Pittsburgh, Pittsburgh, PA

    Background: Alemtuzumab (Campath-1H) is a humanized mAb directed against CD52 that is expressed on all lymphocytes, including CD4+FoxP3+ regulatory T cells (Treg), and that depletes…
  • 2013 American Transplant Congress

    Renal Transplant Recipients (RTR) with Immune Mediated Graft Injury Display Significant Alterations within the Peripheral B Cell Phenotype

    A. Cherukuri, A. Salama, C. Carter, B. Clark, R. Baker

    St. James's University Hospital, Leeds, United Kingdom; UCL, London, United Kingdom

    Phenotypic characterization of PBMCs constitutes part of the immune signature for operational tolerance in RTR. Alterations in the PBMCs of RTR with biopsy proven microcirculation…
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