2013 American Transplant Congress
Levels of IL-33 and Soluble IL-33 Receptor (sST2) Distinguish Acute Rejection from Enteritis in Small Bowel Transplant Recipients
BackgroundIL-33 is a member of the IL-1 cytokine family with functions ascribed to its actions on immune cells expressing the IL-33 receptor, ST2. Following heart…2013 American Transplant Congress
Incorporating Time from Donation (TFD) to the MDRD and CKD-EPI Formulas Enhances Their Performance in Kidney Donors
Introduction:The reexpressed MDRD study equation is least biased in estimating GFR in former kidney donors. Hyperfiltration is not limited to the first year after donation.…2013 American Transplant Congress
In Vivo Interaction between ATG and IVIg May Decrease the Efficacy of Antibody Mediated Rejection Treatment
Treatment of antibody mediated rejection(AMR) is not standardized. Anti-thymocyte globulin(ATG) is commonly used in combination with intravenous immunoglobulin(IVIg) and plasmapheresis(Px). Our in vitro data show…2013 American Transplant Congress
New OPTN Requirement for DNA-Based HLA Typing for Deceased Donors: Initial Results Show Increased Typing Resolution for Improving Virtual Crossmatches, A
UCSF, San Francisco, CA; UNOS, Richmond, VA; Cedars-Sinai, Los Angeles, CA
Historically HLA typing of deceased donors was performed using serological or DNA-based methods. On 6/1/11, the Organ Procurement and Transplantation Network (OPTN) implemented a new…2013 American Transplant Congress
Association of B Cell Population in Splenic Histology of ABO Incompatible Kidney Transplantation and One-Year Graft and Recipient Survival, The
Purpose: To evaluate the association of plasma cell population (PCs) in splenic histology of ABO incompatible (ABO-i) kidney transplant recipients and one year graft and…2013 American Transplant Congress
IRF-1 Regulates Immune Reactivity in Mouse Hepatic Allografts
Introduction: We have shown previously that Interferon Regulatory factor-1 (IRF-1) contributes to liver I/R injury by activating proinflammatory genes, but its role in host responses…2013 American Transplant Congress
Ex Vivo-Expanded Non-Human Primate Regulatory T Cells Are Resistant to Alemtuzumab-Mediated, Complement-Dependent Cytotoxicity
Background: Alemtuzumab (Campath-1H) is a humanized mAb directed against CD52 that is expressed on all lymphocytes, including CD4+FoxP3+ regulatory T cells (Treg), and that depletes…2013 American Transplant Congress
Renal Transplant Recipients (RTR) with Immune Mediated Graft Injury Display Significant Alterations within the Peripheral B Cell Phenotype
St. James's University Hospital, Leeds, United Kingdom; UCL, London, United Kingdom
Phenotypic characterization of PBMCs constitutes part of the immune signature for operational tolerance in RTR. Alterations in the PBMCs of RTR with biopsy proven microcirculation…2013 American Transplant Congress
Impact of Deceased Donor Kidney Risk Significantly Varies by Recipient Characteristics, The
Cleveland Clinic Foundation, Cleveland; Case Western Reserve University, Cleveland
As of May 2012 over 92,000 patients were awaiting a solitary kidney transplant in the United States and new waitlist registrations have been steadily rising…2013 American Transplant Congress
Application of Rejection Reversal as Defined by Efficacy Endpoints in Present Day Renal Transplantation
The Methodist Hospital, Houston, TX
In the 1990s, the Efficacy Endpoints (EE) studies proposed criteria for 'successful' response to rejection treatment based on serum creatinine (Cr) as a marker of…
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