2013 American Transplant Congress
Prolonged Cold Ischemia Impairs Outcome in Recipients of DCD Kidney Transplants, Despite Machine Perfusion
Introduction: The impact of prolonged cold ischemia time (CIT) on kidney grafts donated after circulatory death (DCD) remains unclear when grafts were preserved by hypothermic…2013 American Transplant Congress
High DSA Is Associated with Steroid-Resistant Rejections in Liver Transplantation
UCLA, Los Angeles, CA; Terasaki Foundation Laboratory, Los Angeles, CA
Aim: To determine the prevalence of DSA in acute rejection episodes after liver transplantation and its role as a predictor of clinical response to treatment.Methods:…2013 American Transplant Congress
Axin2/β-Catenin/Notch1 Sigaling Regulates Innate Immunity in Mouse Model of Liver Ischemia/Reperfusion Injury
Dumont-UCLA Transplant Ctr, Dept of Surgery, UCLA School of Medicine, Los Angeles, CA
Background: Axin2 is a multiple function protein involved in many biological pathways, and its overexpression might regulate Β-catenin activity. The Notch signaling is known to…2013 American Transplant Congress
Association of B Cell Population in Splenic Histology of ABO Incompatible Kidney Transplantation and One-Year Graft and Recipient Survival, The
Purpose: To evaluate the association of plasma cell population (PCs) in splenic histology of ABO incompatible (ABO-i) kidney transplant recipients and one year graft and…2013 American Transplant Congress
IRF-1 Regulates Immune Reactivity in Mouse Hepatic Allografts
Introduction: We have shown previously that Interferon Regulatory factor-1 (IRF-1) contributes to liver I/R injury by activating proinflammatory genes, but its role in host responses…2013 American Transplant Congress
Ex Vivo-Expanded Non-Human Primate Regulatory T Cells Are Resistant to Alemtuzumab-Mediated, Complement-Dependent Cytotoxicity
Background: Alemtuzumab (Campath-1H) is a humanized mAb directed against CD52 that is expressed on all lymphocytes, including CD4+FoxP3+ regulatory T cells (Treg), and that depletes…2013 American Transplant Congress
Renal Transplant Recipients (RTR) with Immune Mediated Graft Injury Display Significant Alterations within the Peripheral B Cell Phenotype
St. James's University Hospital, Leeds, United Kingdom; UCL, London, United Kingdom
Phenotypic characterization of PBMCs constitutes part of the immune signature for operational tolerance in RTR. Alterations in the PBMCs of RTR with biopsy proven microcirculation…2013 American Transplant Congress
Significance of Non-Dipping Blood Pressure Profile on Renal Allograft Function
Washington University School of Medicine, St Louis, MO
Hypertension is common in the post transplant period. A few studies in adults have demonstrated an association between nocturnal hypertension and poor renal and cardiovascular…2013 American Transplant Congress
Impact of Deceased Donor Kidney Risk Significantly Varies by Recipient Characteristics, The
Cleveland Clinic Foundation, Cleveland; Case Western Reserve University, Cleveland
As of May 2012 over 92,000 patients were awaiting a solitary kidney transplant in the United States and new waitlist registrations have been steadily rising…2013 American Transplant Congress
Application of Rejection Reversal as Defined by Efficacy Endpoints in Present Day Renal Transplantation
The Methodist Hospital, Houston, TX
In the 1990s, the Efficacy Endpoints (EE) studies proposed criteria for 'successful' response to rejection treatment based on serum creatinine (Cr) as a marker of…
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