2020 American Transplant Congress
B Cell Depletion with Anti-CD20 mAb Exacerbates Anti-Donor CD4+ T Cell Responses in Highly Sensitized Transplant Model
Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan
*Purpose: Preformed donor-specific anti-human leukocyte antigen antibodies (DSAs) have been associated with detrimental effects in transplant recipients. To eliminate preformed DSAs, we desensitized DSA-positive recipients…2020 American Transplant Congress
Torc1 Inhibition Protects Activated Human Regulatory T Cells from Self-Inflicted Damage via Granzyme B
Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
*Purpose: The use of Regulatory T cells (Tregs) in adoptive cell therapy has been hindered by their short survival following their adoptive transfer. We have…2020 American Transplant Congress
Tissue Resident Memory T Cells in Mouse Renal Transplantation
1Starzl Transplantation Institute, Pittsburgh, PA, 2American University of Beirut, Beirut, Lebanon
*Purpose: The newly identified tissue resident subset of memory T cells (TRM) provides immune surveillance in the tissue and first response against infections. They are…2020 American Transplant Congress
Intimal Arteritis in Association with Microvascular Inflammation Leads to Inferior Graft Survival Regardless DSA
*Purpose: Intimal arteritis belongs between diagnostic criteria of both antibody-mediated rejection (AMR) and T cell-mediated vascular rejection (TCMRV). Patients with intimal arteritis must be assessed…2020 American Transplant Congress
Application of Image-Guidance Using 2D Illustrations and 3D Modeling of Donor Anatomy During Living Donor Hepatectomy
Transplantation, Samsung Medical Center, Seoul, Korea, Republic of
*Purpose: For living donor liver transplantation, preoperative imaging is required for the safety of donor and recipient. As we started our image-guidance program using 2D…2020 American Transplant Congress
Neoadjuvant Gem/Cis Followed by Transarterial Radioembolization for Locally Advanced iCCA with Intent for Curative Resection
Transplantation Institute, The University of Chicago, Chicago, IL
*Purpose: Locally advanced intrahepatic cholangiocarcinoma (LAiCCA) has a traditionally poor prognosis with few curative surgical options and a high incidence of postop recurrence. The intent…2020 American Transplant Congress
Artificial Intelligence May Detect Donor Liver Steatosis and Predict Early Post-Transplantation Graft Failure
Stanford University, Stanford, CA
*Purpose: To compare the accuracy of donor liver biopsy slides scored by manual histopathologic review versus a computer vision artificial intelligence (CVAI) platform to predict…2020 American Transplant Congress
Pre-Transplant Monocyte HDAC6 Expression and Risk of Primary Graft Dysfunction in Clinical Lung Transplant Recipients
*Purpose: Lung transplantation (Tx) in ~30% of cases is subject to primary graft dysfunction (PGD), the severe acute lung injury that occurs within 72 hours…2020 American Transplant Congress
In-Vivo Application of Ides (Imlifidase) in Nonhuman Primates Results in Xenoreactive Desensitization: A Novel Anti-Humoral Therapy
*Purpose: Antibody-mediated rejection is a formidable barrier to xenograft survival. A novel anti-humoral IdeS therapy, which cleaves serum IgG, represents a promising therapy to reduce…2020 American Transplant Congress
Predicting Kidney Allograft Discard: The Kidney Discard Risk Index
*Purpose: The disparity between the supply and demand for kidney allografts is exacerbated by an 18.9% discard rate. It is our aim to determine predictors…
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