Am J Transplant, Volume 20, Suppl 3 Archives - Page 98 of 223 - ATC Abstracts

2020 American Transplant Congress
Pharmacist Initiated Hepatitis B Vaccinations in Liver Transplant Recipients
A. Reid¹, S. Todd¹, M. Morrison², A. Adams¹
¹Emory University Hospital, Atlanta, GA, ²Vanderbilt University Medical Center, Nashville, TN
*Purpose: The risk of developing hepatitis B after liver transplantation remains high in nonimmune patients receiving an allograft from a hepatitis B core antibody positive…
2020 American Transplant Congress
Cardiovascular Improvement after Pancreatic Transplantation
S. Y. Suen¹, T. Sparkes¹, R. Kalil², B. Ravichandran¹
¹Pharmacy, University of Maryland Medical Center, Baltimore, MD, ²Nephrology, University of Maryland Medical Center, Baltimore, MD
*Purpose: Cardiovascular disease is a common cause of mortality in patients with uncontrolled diabetes. The purpose of this study is to assess whether patients receiving…
2020 American Transplant Congress
Pig-To-Baboon Liver Xenotransplantation Utilizing Genetically Modified Swine
D. Detelich¹, C. G. Rickert¹, T. M. Coe¹, S. Kimura¹, I. Rosales¹, H. Deng¹, H. Yeh¹, W. Qin², Y. Kan², J. Layer², M. Youd², W. Westlin², L. Yang², J. F. Markmann¹
¹Massachusetts General Hospital, Boston, MA, ²eGenesis, Cambridge, MA
*Purpose: Pig-to-baboon liver xenotransplant (LXT) continues with significant hurdles, including thrombocytopenia, coagulation dysregulation and rejection with the longest reported survival of 29 days utilizing a…
2020 American Transplant Congress
Improving Access to Transplantation and Outcomes for African American Patients
D. Bekbolsynov, O. Ekwenna, B. Mierzejewska, J. Borucka, S. A. Khuder, M. Rees, R. Green, S. Stepkowski
University of Toledo, Toledo, OH
*Purpose: Black or African American patients are clearly disadvantaged in comparison to Caucasian patients both in terms of the access to kidney transplantation and post-transplant…
2020 American Transplant Congress
Urinary Exosomal Hemopexin, a Validated Diagnostic Marker for Rejection in Kidney Transplant Recipients
J. Lee¹, J. Kim², G. Lee², S. Jeon², H. Noh², J. Lim², H. Jung², J. Choi², J. Cho², S. Park², Y. Kim², C. Kim²
¹Internal Medicine, Daegu Fatima Hospital, Daegu, Korea, Republic of, ²Internal Medicine, Kyungpook National University, Daegu, Korea, Republic of
*Purpose: Urinary exosomal hemopexin was identified as a potential diagnostic candidate for kidney allograft rejection in our previous proteomic study. We validated hemopexin as a…
2020 American Transplant Congress
In Silico Deconvolution of Whole Blood RNA-Seq Data from Iscalimab Phase IIa Study in Renal Transplant Reveals Insights Into Mechanism of Action and Superiority of Iscalimab Compared to Tacrolimus
J. S. Rush
Autoimmunity, Transplantation and Inflammation, Novartis Institutes for Biomedical Research, Basel, Switzerland
*Purpose: A recent Phase 2 clinical study indicated that iscalimab, a pathway blocking, non-depleting anti-CD40 antibody, showed non-inferiority on a composite clinical endpoint, and improved…
2020 American Transplant Congress
Prognostic Impact of Peritumoral Neutrophil Infiltration on Hepatocellular Carcinoma Recurrence Following Liver Transplantation
M. Najjar¹, K. Halazun², M. Mondal¹, A. Srivastava¹, M. Moore¹, E. Rizk¹, R. Gartrell¹, H. Remotti¹, L. Fazlollahi¹, E. Verna¹, A. Griesemer¹, A. Mathur¹, B. Samstein², J. Emond¹, Y. Saenger¹
¹Columbia University Irving Medical Center, New York, NY, ²Weill Cornell Medicine, New York, NY
*Purpose: Peritumoral neutrophil (PMN) infiltration has been associated with poor clinical outcomes in various tumors; however, its role in hepatocellular carcinoma (HCC) remains understudied. Moreover,…
2020 American Transplant Congress
Role of Circulating Exosomes in the Induction of Immune Responses Resulting in Cardiac Allograft Rejection in miR155 Knockout Animals
S. Bansal, Y. Itabashi, M. Smith, R. Bremner, T. Mohanakumar
Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ
*Purpose: Our goal is to define the mechanism by which circulating exosomes with cardiac self-antigens (SAgs), Myosin, Vimentin, and angiotensin Receptor 1 Protein (AGTR1) leads…
2020 American Transplant Congress
Platelets Stimulate Liver Regeneration in a 30% Partial Liver Transplantation Model in Rat
K. Takahashi, C. Liang, N. Ohkohchi, T. Oda
University of Tsukuba, Tsukuba, Japan
*Purpose: Liver transplantation (LT) is one of the most definitive treatments for patients with end-stage liver disease and acute liver failure, and it has been…
2020 American Transplant Congress
Induction of Transplant Tolerance by Modulating the Metabolic Stress Pathways
X. Xiao, L. Zhang, Y. Ying, Y. Wang, P. Arnold, Z. Zhang, X. Li
Houston Methodist Research Institute, Houston, TX
*Purpose: T cell activation and effector differentiation precede graft rejection, and this process is associated with robust metabolic burst to meet the energy demand of…