Am J Transplant, Volume 20, Suppl 3 Archives - Page 98 of 223 - ATC Abstracts

2020 American Transplant Congress
Benefits of Transplantation Over Chronic Dialysis in Septugenerian ESRD Patients with Diabetes
S. Karhadkar, A. Shaik, A. Di Carlo
Temple University School of Medicine, Philadelphia, PA
*Purpose: In 2016, nearly 125,000 adults in the United States began treatment for end-stage renal disease (ESRD) (i.e., kidney failure requiring dialysis or transplantation). Of…
2020 American Transplant Congress
Migration of Passenger Leukocytes During Ex Vivo Warm Perfusion
L. Brasile¹, B. Stubenitsky²
¹Research and Development, BREONICS Inc., Watervliet, NY, ²Plastic, Reconstructive & Aesthetic Surgery, St. Antonius Hospital, Utrecht, Netherlands
*Purpose: Organ transplantation is a unique immunologic situation in which donor and recipient antigen presenting cells (APCs) are present upon reperfusion. Passenger leukocytes (PL) are…
2020 American Transplant Congress
Opioid Use Prior to Liver Transplant is Associated with Increased Risk of Death after Transplant
H. J. Braun, M. P. Schwab, C. Jin, D. Amara, T. Grace, R. Croci, C. E. Freise, J. P. Roberts, R. Hirose, N. L. Ascher
University of California, San Francisco, San Francisco, CA
*Purpose: The impact of the opioid epidemic on liver transplant (LT) candidates and recipients has not been widely studied, but pre-LT opioid use in LT…
2020 American Transplant Congress
Pretransplant BKV-IgG Serostatus and BKV-Specific ELISPOT Assays for the Prediction of BKV Infection
H. Bae¹, J. Jang¹, H. Lee², S. Yun¹, E. Oh³
¹Department of Biomedical Science, Graduate School, Catholic University of Korea, Seoul 137-040, Korea, Republic of, ²Department of Laboratory Medicine, Catholic Kwandong University of Korea, Incheon, Korea, Republic of, ³Department of Laboratory Medicine, Catholic University of Korea, Seoul 137-040, Korea, Republic of
*Purpose: BK Polyomavirus (BK) can lead to major infectious complications and damage to the graft in kidney transplantation (KT). We investigated whether pretransplant BK serostatus…
2020 American Transplant Congress
Th17 Cell Inhibition in a Costimulation Blockade Based Regimen for Vascularized Composite Allotransplantation Using A Non-Human Primate Model
D. P. Moris, A. Atia, M. Rae, M. Song, L. Stempora, F. Leopardi, K. Williams, J. Kwun, W. Parker, A. Cardones, A. D. Kirk, L. C. Cendales
Surgery, Duke, Durham, NC
*Purpose: Vascularized composite allotransplantation (VCA) is challenged by the morbidity of non-specific immunosuppression required to prevent rejection. The use of highly specific biologics has not…
2020 American Transplant Congress
Normothermic Ex-Vivo Kidney Perfusion is Superior to Anoxic and Oxygenated Hypothermic Machine Perfusion for the Preservation of DCD Porcine Kidney Grafts
L. Mazilescu¹, M. Kaths², P. Urbanellis¹, M. Hamar³, T. Goto¹, I. Linares-Cervantes¹, Y. Noguchi¹, A. Konvalinka¹, A. Ghanekar¹, D. Bagli⁴, R. John⁵, L. Robinson⁶, M. Selzner¹
¹Multi Organ Transplant Program, Toronto General Hospital, Toronto, ON, Canada, ²Department of General, Visceral, and Transplantation Surgery, University Hospital Essen, Essen, Germany, ³Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary, ⁴Departments of Surgery(Urology)&Physiology, The Hospital for Sick Children, Toronto, ON, Canada, ⁵Laboratory Medicine & Pathobiology, Toronto General Hospital, Toronto, ON, Canada, ⁶Division of Nephrology, The Hospital for Sick Children, Toronto, ON, Canada
*Purpose: To increase the donor pool, better preservation strategies for the storage of marginal kidney grafts are crucial. Currently, kidney grafts are either stored on…
2020 American Transplant Congress
Desensitization for Deceased Donor Transplantation: Testing a New Paradigm in the Nonhuman Primate
Z. W. Fitch, R. Schmitz, P. M. Schroder, M. Manook, A. Y. Choi, J. Yoon, J. Kwun, S. J. Knechtle
Duke University, Durham, NC
*Purpose: Desensitization regimens have rarely been applied to deceased donor allotransplantation. We hypothesized that belatacept monotherapy during a simulated deceased donor waiting list period would…
2020 American Transplant Congress
Pilot Donor App Users Maintain Higher Transplant Rates Than Matched Controls
L. R. Herbst, A. D. Love, P. Chiang, K. Kumar, B. King, A. Massie, J. Garonzik Wang, D. L. Segev, A. M. Cameron
Johns Hopkins University, Baltimore, MD
*Purpose: We previously conducted a pilot study demonstrating that patients who used the Donor App (DA) were 6.6 times more likely to generate a live…
2020 American Transplant Congress
Peak DSA Levels Pre-Transplant but Not at Transplant Predict Graft Survival
A. Y. Choi¹, D. Olaso¹, T. Risoli Jr², M. Kuchibhatla², Z. Fitch³, R. Schmitz³, P. M. Schroder³, A. Jackson³, M. Manook³, J. Yoon³, A. B. Farris⁴, J. Kwun³, S. J. Knechtle³
¹Duke University School of Medicine, Durham, NC, ²Duke Biostatistics, Epidemiology, and Research Design Core, Duke University, Durham, NC, ³Department of Surgery, Duke University Medical Center, Durham, NC, ⁴Department of Pathology, Emory University Hospital, Atlanta, GA
*Purpose: Immunization to major histocompatibility complex (MHC) antigens is a barrier in kidney transplantation (KTx) due to higher risk of antibody-mediated rejection (AMR) and graft…
2020 American Transplant Congress
The Changes of Transaminases, Lactate Dehydrogenase and pH Levels During Normothermic Liver Preservation Correlate with Early Allograft Dysfunction
C. Bogensperger
Department of Visceral, Transplant and Thoracic Surgery, Medical University Innsbruck, Innsbruck, Austria
*Purpose: Normothermic liver preservation (NMP) has become a clinically established tool to preserve livers in a near-physiological environment. Currently, decreasing lactate and physiological pH-levels are…