Am J Transplant, Volume 20, Suppl 3 Archives - Page 98 of 223 - ATC Abstracts

2020 American Transplant Congress
Ex Vivo Generated Regulatory B Cells Can Suppress Donor-Specific CD4 T Cells Proliferation In Vivo
G. Huai¹, K. M. Lee¹, Q. Fu¹, K. Deng¹, N. J. Feeney¹, C. Leguern¹, N. Tanimine¹, C. G. Rickert¹, S. Deng², J. F. Markmann¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Organ Transplantation Center, Sichuan Provincial People's Hospital and School of Medicine, University of Electronic Science and Technology of China, Chengdu, China
*Purpose: B cells expanded in vitro via TLR9 agonist CpG and activated by LPS, PMA and ionomycin have been previously denoted “TLR-Bregs” by our team.…
2020 American Transplant Congress
Characterization of CpG-stimulated, Tlr Regulatory, and Expanded Regulatory B Cells by RNA-Seq
Q. Fu, G. C. Rickert, K. Lee, G. Huai, K. Deng, N. Feeney, N. Tanimine, A. Cuenca, S. Deng, J. F. Markmann
Center for Transplant Science, MGH, Boston, MA
*Purpose: Our group previously reported three different types of in vitro generated B cell populations. Expanded regulatory B cells (eBregs), TLR regulatory B cells (TLR-Bregs),…
2020 American Transplant Congress
Activation of Tacrolimus Induced Cytotoxicity Through Apoptotic Pathways
S. Chung, S. Choi
Department of Surgery, Chonnam National University, Gwangju, Korea, Republic of
*Purpose: To elucidate the mechanism of cytotoxicity in FK506-treated Jurkat T cells, signal transduction pathway of TNF-related events was studied.*Methods: Viability of Jurkat T cells…
2020 American Transplant Congress
Decreased Anti-Tumor Activity of Liver-Resident NK Cells via IL-33 Associated with Portal Hypertension after Living Donor Liver Transplantation
Y. Imaoka, M. Ohira, K. Sato, H. Ohdan
Hiroshima Uni., Hiroshima, Japan
*Purpose: It has been reported that increasing portal vein pressure after living donor liver transplantation (LDLT) was associated with a poor prognosis, risk factors for…
2020 American Transplant Congress
Development and Characterization of Decellularized Whole Human Livers for Increasing Donor Pool
A. Acun, R. Oganesyan, B. E. Uygun
Massachusetts General Hospital - Harvard Medical School, Boston, MA
*Purpose: Liver diseases are recognized as the second leading cause of mortality amongst all digestive diseases in the United States. Orthotopic liver transplantation leads to…
2020 American Transplant Congress
Outcomes of Kidney Transplant Recipients with Depression and Anxiety
D. Keys, S. Jackson, S. M. Riad, R. Spong, A. Matas
University of Minnesota, Minneapolis, MN
*Purpose: The outcomes of kidney transplantation in patients with depression and anxiety have been limited by small numbers. This is despite high prevalence of these…
2020 American Transplant Congress
Older Organs Transfer Senescence to Transplant Recipients
J. Iske¹, R. Maenosono¹, M. Seyda¹, T. Heinbockel¹, M. Koichiro¹, Y. Nian¹, T. Tchkonia², J. L. Kirkland², R. Abdi¹, A. Elkhal¹, S. G. Tullius¹
¹Brigham and Women's Hospital, Boston, MA, ²Mayo Clinic, Rochester, MN
*Purpose: Older organs represent an underutilized potential. Organ age, at the same time, augments alloimmune responses resulting into increased acute rejection rates. Senescent cells accumulate…
2020 American Transplant Congress
Clinically Adjudicated Deceased Donor AKI and Graft Outcomes
S. G. Mansour¹, N. Khoury¹, S. Vermani¹, R. Koladi¹, I. Hall², P. Reese³, S. Mohan⁴, M. Doshi⁵, M. Harhay⁶, J. Bromberg⁷, M. Thangamani⁸, P. Singh⁹, Y. Jia¹⁰, H. Thiessen-Philbrook¹⁰, E. Akalin¹¹, F. Weng¹², B. Schroeppel¹³, J. Greenberg¹, D. Moledina¹, F. P. Wilson¹, C. Parikh¹⁰
¹Yale, New Haven, CT, ²Utah Univ, Salt Lake City, UT, ³UPenn, Philadelphia, PA, ⁴Columbia, New York, NY, ⁵Univ of Michigan, Ann Arbor, MI, ⁶Drexel, Philadelphia, PA, ⁷Univ of Maryland, College Park, MD, ⁸Cornell, NY, NY, ⁹Thomas Jefferson, Philadelphia, PA, ¹⁰Johns Hopkins, Baltimore, MD, ¹¹Montefiore, Bronx, NY, ¹²St Barnabas, Livingston, NJ, ¹³Univ Hosp, Ulm, Germany
*Purpose: We previously reported that AKI in deceased donors isn't associated with graft failure. As deceased donors undergo significant hemodynamic changes, we hypothesized that reversible…
2020 American Transplant Congress
Compatible Pairs- Providingan Option to Upgrade
V. Chipman¹, M. Cooper², S. Flechner³, G. Hil⁴, D. Leeser⁵, D. Mandelbrot⁶, M. Ronin⁴, D. Segev⁷, S. Syed⁸, A. Thomas⁹, A. Waterman¹⁰, G. R. Roll¹¹
¹Kidney Transplant, UCSF, San Francisco, CA, ²Georgertown, Washington, DC, ³Cleavland Clinic, Cleavland, OH, ⁴NKR, Babylon, NY, ⁵East Carolina Univ, Greenville, NC, ⁶University of Wisconsin, Madison, WI, ⁷Johns Hopkins, Boltimore, MD, ⁸UCSF, San Francisco, CA, ⁹Johns Hopkins, Baltimore, MD, ¹⁰UCLA and Terasaki Research Institute, Los Angeles, CA, ¹¹Surgery, Division of Transplant, UCSF, San Francisco, CA
*Purpose: Compatible pairs (CPs) can enter an exchange program instead of donating directly. These pairs increase transplants (txp) by providing additional donors within an exchange…
2020 American Transplant Congress
HCV-Positive Donors Are Healthier and Inequitably Utilized in the United States
B. L. Da, T. Kushner, G. Kakked, J. Crismale, G. Ezaz, T. Schiano, B. Saberi
Liver Disease, Icahn School of Medicine at Mount Sinai, New York, NY
*Purpose: Increased utilization of HCV-positive (HCV+) liver allografts has been endorsed as a solution to the national organ shortage. Due to the opioid epidemic, there…