Am J Transplant, Volume 20, Suppl 3 Archives - Page 94 of 223 - ATC Abstracts

2020 American Transplant Congress
Xenoantibody Depletion of Human Blood with Normothermic Machine Perfusion of Porcine Kidney and Lung Prior to Liver Perfusion
T. M. Coe¹, N. Serifis¹, S. Raigani¹, C. Carroll¹, C. G. Rickert¹, R. Matheson¹, D. Detelich², W. Qin³, Y. Kan³, J. Layer³, M. Youd³, W. Westlin³, L. Yang³, A. Azimzadeh¹, J. F. Markmann¹
¹Surgery, Massachusetts General Hospital, Boston, MA, ²Surgery, Tufts Medical Center, Boston, MA, ³eGenesis, Cambridge, MA
*Purpose: Genetic modifications of porcine donors for pig-to-human xenotransplantation have led to significant progress in survival of xenografts in preclinical models. Triple knock-out (TKO) of…
2020 American Transplant Congress
Impact of Desensitization Strategies with Proteosome Inhibition and Costimulation Blockade on Xenoreactive Humoral Responses
B. P. Lovasik¹, A. J. Matar¹, D. A. Faber¹, D. V. Mathews¹, C. P. Breeden¹, S. C. Kim¹, A. J. Tector², A. B. Adams¹
¹Emory University School of Medicine, Atlanta, GA, ²University of Miami, Miami, FL
*Purpose: “Delayed” antibody-mediated xenograft rejection is the one of the most important obstacles to clinical application of pig organ xenografts. The aim of this study…
2020 American Transplant Congress
Native Nephrectomy at the Time of Transplant: Risk for Adrenal Injury?
T. Salinas¹, D. Dadhania¹, J. Lee¹, M. Aull¹, S. Kapur², M. Lubetzky¹
¹Nephrology, NY Presbyterian- Weill Cornell, New York, NY, ²Surgery, NY Presbyterian- Weill Cornell, New York, NY
*Purpose: Living donor studies have demonstrated that native nephrectomy (Nx) is associated with transient but symptomatic loss of adrenal function. Although surgical complications from simultaneous…
2020 American Transplant Congress
Persistent Fibrinolysis Shutdown in Liver Transplant Recipients is Associated with Early Allograph Dysfunction
H. B. Moore¹, T. Nydam¹, J. Pomposelli¹, C. Walker¹, A. Schulick¹, R. Choudhury¹, H. Yaffe¹, M. Adams², M. Cohen³, E. Pomfret¹
¹University of Colorado, Aurora, CO, ²Childrens Hospital, Aurora, CO, ³Denver Health Medical Center, Denver, CO
*Purpose: Early allograph dysfunction (EAD) in liver transplantation has been attributed to microvascular thrombosis. Treating grafts at risk of EAD with tissue plasminogen activator (tPA)…
2020 American Transplant Congress
Identifying Factors Associated with Delayed Graft Function Severity Using the OPTN Database
K. Checchi¹, D. Stewart², A. Toll², J. Case¹, S. Kurian¹, C. Marsh¹
¹Scripps Health, La Jolla, CA, ²United Network for Organ Sharing Research Department, Richmond, VA
*Purpose: Delayed graft function (DGF) is a costly adverse outcome in kidney transplantation with negative implications for both graft and patient survival. Identifying factors associated…
2020 American Transplant Congress
Transplant Relevant MDSC Genetics: Differential Gene Expression Profiles of Immunosuppressive Myeloid-Derived Suppressor Cells Induced by Granulocyte-Colony Stimulating Factor
Y. S. Lee, J. S. Bromberg, J. R. Scalea
Department of Surgery, University of Maryland, Baltimore, MD
*Purpose: Myeloid-derived suppressor cells (MDSC) are expanded in inflammation conditions and can control alloreactive T cell responses. Granulocyte-colony stimulating factor (GCSF) is known to induce…
2020 American Transplant Congress
Risk Stratification in Antibody Incompatible Kidney Transplantation: Can Aggressive Rejection be Avoided?
S. Punjala¹, M. Ibrahim¹, N. Vallant¹, N. Kessaris¹, O. Shaw², N. Mamode¹
¹Department of Nephrology, Renal Transplant and Urology, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom, ²Clinical Transplantation Laboratory, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom
*Purpose: Our experience in antibody incompatible kidney transplantation, and anecdotal reports, suggest that a specific form of rejection, which we term Early Aggressive Antibody Mediated…
2020 American Transplant Congress
Modulation of Ischemia Reperfusion Injury in Renal Transplantation Using Selective Estrogen Receptor Modulators
P. T. Hernandez¹, C. S. O'Brien¹, S. J. Concors¹, L. N. Krumeich¹, W. Hancock², M. H. Levine¹
¹Hospital of the University of Pennsylvania, Philadelphia, PA, ²Children's Hospital of Philadelphia, Philadelphia, PA
*Purpose: Renal ischemia reperfusion injury (IRI) is a major contributor to delayed graft function (DGF) in kidney transplantation. We previously demonstrated lower rates of DGF…
2020 American Transplant Congress
MHC II-Decoy Car-T Cells to Induce Long-Term Allotransplant Organ Tolerance
W. McCall¹, T. Baybutt¹, A. Snook¹, A. Shah²
¹Department of Pharmacology and Experimental Therapeutics, Sidney Kimmel Medical College, Philadelphia, PA, ²Department of Surgery, Division of Transplantation, Sidney Kimmel Medical College, Philadelphia, PA
*Purpose: Allotransplantation represents the definitive therapy for end-stage renal, heart, liver, and lung disease. Current immunosuppressive regimens fail to promote long-term engraftment, leading to chronic…
2020 American Transplant Congress
Valganciclovir for Epstein-Barr Virus Prevention after Pediatric Kidney Transplant
R. Jackson¹, S. Mehra², E. Smith¹, C. Peterson², E. Benefield¹, R. Ensign¹, J. Sherbotie², C. Heyrend¹
¹Intermountain Healthcare, Salt Lake City, UT, ²University of Utah, Salt Lake City, UT
*Purpose: Epstein-Barr virus (EBV) infection after pediatric kidney transplant (pKTx) is common and can lead to post transplant lymphoproliferative disorder (PTLD). Valganciclovir (VGN) is used…