Am J Transplant, Volume 20, Suppl 3 Archives - Page 94 of 223 - ATC Abstracts

2020 American Transplant Congress
Using HCV Infected Organs and the Challenge of Third-Party Payers
R. Daloul, A. Michaels, L. Sobotka, T. Pesavento, K. Washburn
Comprhensive Transplant Center, The Ohio State University, Columbus, OH
*Purpose: The practice of transplanting organs from hepatitis C viremic donors (HCV NAT+) into negative recipients hinges on the ability to ensure direct acting antiviral…
2020 American Transplant Congress
Associations of Chronic Kidney Disease with Temperature, Ancestry and Employment
A. A. Connor, B. I. Shaw, K. V. Ravindra
Surgery, Duke University, Durham, NC
*Purpose: We sought to assess the suggested associations of chronic kidney disease (CKD) of unknown origin, also known as Mesoamerican Nephropathy, with temperature, ancestry and…
2020 American Transplant Congress
Microbiota Modulates Ischemia-Reperfusion Injury in Mouse Liver Transplantation
S. Kageyama¹, H. Kojima¹, K. Kadono¹, H. Hirao¹, K. J. Dery¹, K. Nakamura², T. Dong³, J. Jacobs³, R. W. Busuttil¹, J. W. Kupiec-Weglinski¹
¹Surgery, Dumont-UCLA Transplant Center, Los Angeles, CA, ²Surgery, Nishi Kobe Medical Center, Kobe, Japan, ³The Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, Los Angeles, CA
*Purpose: Ischemia-reperfusion injury (IRI) is a major risk factor in orthotopic liver transplantation (OLT). As host microbiota may associate with health or disease, antibiotics (Abx)…
2020 American Transplant Congress
Noninvasive Genotyping of Donor’s HLA in Kidney Transplant Patients by Target Capture Sequencing
T. Jiang, L. Shu, F. Liu, H. Liu, J. Ge
AlloDx, Shanghai; Suzhou, China
*Purpose: Antibody-mediated rejection (ABMR) is the major cause of kidney transplant failure, which requires donor-specific antibodies (DSA) for a definitive diagnosis based on Banff 2013.…
2020 American Transplant Congress
Induction of Delayed Immune Tolerance after Reconstructive Transplantation by Combining Donor Bone Marrow Transplantation and High-Dose Cyclophosphamide Treatment
Y. Guo¹, F. Messner¹, B. Oh¹, G. Furtmüller¹, W. Lee¹, D. Cooney¹, L. Luznik², G. Brandacher¹
¹Plastic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, ²Hematology, Johns Hopkins University School of Medicine, Baltimore, MD
*Purpose: Immunosuppression avoidance by induction of immune tolerance represents a primary goal in the field of transplantation. Yet, success of this concept relies on extensive…
2020 American Transplant Congress
Evaluation of Pretransplant Serologies and Vaccination Rates in Kidney Transplant Candidates
S. Schneider, C. Truax, A. Carlson, B. Clark, B. Sirandas, L. Smith
Department of Pharmacy Services, University of Utah Health, Salt Lake City, UT
*Purpose: Assessing serologic status presents opportunities to provide live vaccinations to solid organ transplant (SOT) candidates. This is especially important given the increased risk of…
2020 American Transplant Congress
Noninvasive Detection of Subclinical Rejection in Urine RNA
K. S. Keslar¹, D. Margeta¹, J. J. Friedewald², M. Abecassis², R. B. Mannon³, P. S. Heeger⁴, R. L. Fairchild¹
¹Cleveland Clinic, Cleveland, OH, ²Northwestern University, Chicago, IL, ³University of Alabama at Birmingham, Birmingham, AL, ⁴Icahn School of Medicine, New York, NY
*Purpose: Subclinical rejection may lead to long-term graft injury and can currently only be detected by repeated biopsies. A noninvasive method is needed to monitor…
2020 American Transplant Congress
Renal Immunoproteasome Function: A Possible Cause for Macrophage Associated Organ Damage During Renal Transplantation?
N. Parajuli, A. Khakurel
University of Arkansas for Medical Sciences, Little Rock, AR
*Purpose: A major hurdle in the field of renal transplantation is the shortage of suitable donor kidneys. Renal transplantation using living-donor organs perform better when…
2020 American Transplant Congress
ANG-3777, A Hepatic Growth Factor Mimetic, Attenuates Mercuric Chloride-Induced Renal Dysfunction and Mortality in Rats
P. Narayan, I. D. Goldberg
Angion Biomedica, Uniondale, NY
*Purpose: ANG-3777 is a small-molecule mimetic of hepatocyte growth factor (HGF). In vitro models have shown ANG-3777 to have protective effects in renal cell lines,…
2020 American Transplant Congress
Ex Vivo Generated Regulatory B Cells Can Suppress Donor-Specific CD4 T Cells Proliferation In Vivo
G. Huai¹, K. M. Lee¹, Q. Fu¹, K. Deng¹, N. J. Feeney¹, C. Leguern¹, N. Tanimine¹, C. G. Rickert¹, S. Deng², J. F. Markmann¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Organ Transplantation Center, Sichuan Provincial People's Hospital and School of Medicine, University of Electronic Science and Technology of China, Chengdu, China
*Purpose: B cells expanded in vitro via TLR9 agonist CpG and activated by LPS, PMA and ionomycin have been previously denoted “TLR-Bregs” by our team.…