2020 American Transplant Congress
Pig-To-Baboon Liver Xenotransplantation Utilizing Genetically Modified Swine
1Massachusetts General Hospital, Boston, MA, 2eGenesis, Cambridge, MA
*Purpose: Pig-to-baboon liver xenotransplant (LXT) continues with significant hurdles, including thrombocytopenia, coagulation dysregulation and rejection with the longest reported survival of 29 days utilizing a…2020 American Transplant Congress
Extended HLA Typing of Kidney Transplant Pairs is Necessary to Assign Presence of Donor-Specific Anti-HLA Antibodies
*Purpose: The need for extended high-resolution (HR) HLA genotyping in solid organ transplantation is currently widely debated due to higher costs and questioned clinical importance.…2020 American Transplant Congress
Combined Phenotyping to Identify Kidney Transplants at Greatest Risk after Subclinical Acute Rejection
*Purpose: We hypothesize that the combination of protocol biopsy histology and gene expression profiles (GEP) for subclinical acute rejection (subAR) in the blood will improve…2020 American Transplant Congress
Transitional B Cell Cytokines for the Early Prediction of Long-Term Renal Allograft Decline
1Starzl Transplantation Institute, UPMC, Pittsburgh, PA, 2UCL, London, London, United Kingdom
*Purpose: Early prediction of allograft loss using potentially modifiable risk factors is vital for conceiving novel therapeutic interventions to improve outcomes.*Methods: In this prospective, multicenter…2020 American Transplant Congress
Small RNA Extracellular Vesicles Isolated from Liver Perfusate Provides Assessment of Organ Quality and Post Transplantation Graft Function
*Purpose: Donor quality plays a critical role during IRI and early graft outcomes. Extracellular vesicles (EVs) provide a novel source of valuable biomarkers that may…2020 American Transplant Congress
Lateral Flow Assay to Detect Soluble CD25 after Kidney Transplantation
Faculty of Natural Sciences, Institute of Technical Chemistry, Hannover, Germany
*Purpose: Kidney transplantations are one of the most common transplantations in the world; 80.696 kidneys were transplanted in 2017. Despite tremendous improvements in quality and…2020 American Transplant Congress
Single Cell Analysis Reveals Endothelial Activation of Interleukin-6 Mediated Signaling Pathway in Microvascular Inflammation with and without c4d
1University of Michigan, Ann Arbor, MI, 2Henry Ford Hospital, Detroit, MI
*Purpose: Microvascular inflammation (MVI) is a feature of antibody mediated rejection. MVI can be seen with or without activation of other effectors of antibody injury…2020 American Transplant Congress
Autologous Expanded Tregs Promote Bone Marrow Engraftment and Donor Kidney Survival in Non-Human Primate Chimerism Model
*Purpose: Mixed chimerism (MC) induced with non-myeloablative conditioning in monkeys and humans induces tolerance to 70% of kidney grafts transplanted at the time of BMT.…2020 American Transplant Congress
Recurrent Focal Segmental Glomerulosclerosis and the Possibility of Re-Transplantation
1Urology, UCLA, Los Angeles, CA, 2Nephrology, UCLA, Los Angeles, CA
*Purpose: Up to 30% of patients with focal segmental glomerulosclerosis (FSGS) experience recurrent disease after renal transplant, with high rates of progression to allograft failure…2020 American Transplant Congress
Higher State-Level Demand for Renal Transplantation is Associated with Lower Deceased Donor Kidney Transplantation Rate
University of Alabama at Birmingham Hospital, Birmingham, AL
*Purpose: Geographic disparities in deceased donor kidney transplantation (DDKT) persist despite increased allocation system oversight and complexity. The association between poor population health and fewer…
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