Am J Transplant, Volume 20, Suppl 3 Archives - Page 86 of 223 - ATC Abstracts

2020 American Transplant Congress
Multi-Center, Open-Label Trial of Pre-Emptive Glecaprevir/Pibrentasvir (G/P) to Treat Recipients of Transplanted Kidneys from Deceased Donors with Hepatitis C Virus (MYTHIC)
M. Sise¹, D. Goldberg², J. Kort³, D. Schaubel⁴, R. Alloway⁵, C. Durand⁶, R. Fontana⁷, J. Friedewald⁸, R. Brown⁹, S. Prenner¹⁰, R. Landis⁴, P. Reese¹¹, R. Chung¹
¹Internal Medicine - Nephrology, MGH, Boston, MA, ²Hepatology and Transplantation, U Miami, Miami, FL, ³Abbvie, Chicago, IL, ⁴Department of Biostatistics, U Penn, Philadelphia, PA, ⁵Department of Internal Medicine - Nephrology and Hypertension, U Cincinnati, Cincinnati, OH, ⁶Department of Medicine, JHU, Baltimore, MD, ⁷Internal Medicine - Gastroenterology, U Michigan, Ann Arbor, MI, ⁸Internal Medicine - Nephrology and Hypertension, Northwestern, Chicago, IL, ⁹Internal Medicine - Hepatology, Weill Cornell, NYC, NY, ¹⁰Internal Medicine - Gastroenterology, U Penn, Philadelphia, PA, ¹¹Transplant Nephrology, U Penn, Philadelphia, PA
*Purpose: Kidneys from Hepatitis C virus (HCV)-infected deceased donors continue to be discarded at high rates despite small, successful studies of HCV-viremic donors into uninfected…
2020 American Transplant Congress
Outcomes of Heart Transplantation in Adults with Congenital Heart Disease Since UNOS Allocation System Change: UNOS Registry Analysis
P. Genyk, K. Yang, J. Nattiv, G. Liu, P. Banankah, P. Kingsford, J. Li, S. Nuno, K. Pandya, A. Vaidya, E. DePasquale
Department of Cardiology, Keck Medical Center of University of Southern California, Los Angeles, CA
*Purpose: We sought to examine the waiting list and post-HT outcomes in patients with congenital heart disease (CHD) within UNOS registry since the implementation of…
2020 American Transplant Congress
Notch Signaling Inhibition via Blockade of Delta-Like Ligand 4 Prevents Co-Stimulation Blockade Resistant Allograft Rejection
A. J. Matar, B. P. Lovasik, Y. Dong, D. A. Faber, J. Habib, C. A. Breeden, J. Regenold, A. Ghosh, A. Stephenson, W. H. Kitchens, A. B. Adams
Surgery and Transplantation, Emory University, Atlanta, GA
*Purpose: Co-stimulation blockade (CoB) has emerged as a promising immunosuppression strategy with the advent of Belatacept, a novel CTLA4-Ig fusion protein that blocks CD28-mediated T…
2020 American Transplant Congress
Highly Effective Short Course Therapy to Prevent Infection after Transplantation from HCV-Infected Organ Donors to Uninfected Recipients across Multiple Organ Types
A. Humar¹, M. Cypel¹, D. Kumar¹, H. Dahari², R. Vanin Pinto Ribeiro¹, N. Marks¹, N. Kamkar¹, I. Bahinskaya¹, F. Onofrio³, M. A. Zahoor³, O. Cerrochi³, K. Tinckam¹, S. J. Kim¹, T. W. Reichman¹, M. McDonald¹, T. K. Waddell¹, G. Sapisochin¹, M. Selzner¹, S. Keshavjee¹, H. L. Janssen³, B. E. Hansen³, L. Singer¹, J. Feld³
¹Transplant Centre, Toronto General Hospital, Toronto, ON, Canada, ²Loyala University, Chicago, IL, ³Toronto General Hospital, Toronto, ON, Canada
*Purpose: An increasing percentage of potential organ donors are infected with hepatitis C virus (HCV). Establishment of HCV infection in uninfected recipients is near-universal with…
2020 American Transplant Congress
Beyond the Margin: Using Kidneys from Donors on Dialysis
P. S. Patel¹, S. Karir², V. R. Peddi¹, H. Mahanty¹, S. Katznelson¹, J. Bellingham¹, N. Neidlinger¹, A. Hassoun¹, A. Sandhu¹, N. Garg¹, L. Mayen³, W. Bry¹
¹CPMC Dept of Transplantation, San Francisco, CA, ²Lewis and Clark College, Portland, OR, ³Donor Network West, San Ramon, CA
*Purpose: Outcomes for transplantation from donors with acute kidney injury have been favorable. The definition and severity of AKI have been variable. Donors who are…
2020 American Transplant Congress
Hydroxychloroquine is Associated with Better Patient and Graft Survival in Kidney Transplant Patients with Lupus Nephritis as Cause of ESRD
T. Singh¹, S. Garg², S. Panzer¹
¹Nephrology, University of Wisconsin, Madison, WI, ²Rheumatology, University of Wisconsin, Madison, WI
*Purpose: Hydroxychloroquine (HCQ) use leads to better patient and renal survival in patients with lupus nephritis (LN). Whether the clinical benefits of HCQ extends to…
2020 American Transplant Congress
Incidence of Chronic Kidney Disease after Liver Transplantation Using Measured GFR
N. R. Mazumder¹, J. Levitsky¹, G. Saracino², G. Klintmalm³, J. Trotter², S. Asrani²
¹Gastroenterology and Hepatology, Northwestern University, Chicago, IL, ²Transplant Hepatology, Baylor University Medical Center Dallas, Dallas, TX, ³Transplant Surgery, Baylor University Medical Center Dallas, Dallas, TX
*Purpose: Historical rates of ESRD after LT are 8% (1 year) and 18% (5 years) (Ojo NEJM 2003). However, these rates were based older estimates…
2020 American Transplant Congress
Improving Liver Transplant (LT) Waitlist Attrition
W. Concepcion¹, A. Ahmed¹, Z. Tulu², L. Hogan², A. Bonham¹, A. Gallo¹, M. Melcher¹, P. Kwo¹, C. Esquivel¹
¹Stanford University Medical Center, Palo Alto, CA, ²Stanford Health Care, Palo Alto, CA
*Purpose: LT patients are listed with the goal of receiving a transplant. Jan-2018 SRTR report showed that our observed waitlist (WL) mortality rate was 11.8…
2020 American Transplant Congress
Outcomes of Simultaneous Pancreas and Kidney Transplantation Based on Donor Resuscitation
F. Messner¹, J. W. Etra², Y. Yu³, K. Jackson², A. B. Massie², G. Brandacher², S. Schneeberger⁴, C. Margreiter⁴, D. L. Segev²
¹Johns Hopkins University School of Medicine, Baltimore, MD, ²Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, ³Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD, ⁴Department of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, Innsbruck, Austria
*Purpose: It has been hypothesized that transplanting simultaneous pancreas kidney (SPK) grafts from donors with a history of cardiac arrest and cardiopulmonary resuscitation (CACPR) leads…
2020 American Transplant Congress
Accelerated Bronchiolitis Obliterans after Lung Transplant Promoted by the ATG16L1 rs2241880 Mutation is Coupled to Mitochondrial Damage and Metabolic Alterations in Monocyte-Derived Alveolar Macrophages
M. Cano¹, D. Zhou², D. Kreisel³, C. Chen⁴, K. Pugh², D. Byers¹, R. Hachem¹, A. E. Gelman³
¹Pulmonary and Critical Care, Washington University, Saint Louis, MO, ²Surgery, Washington University, Saint Louis, MO, ³Surgery and Pathology and Immunology, Washington University, Saint Louis, MO, ⁴Pulmonary and Critical Care, Southwestern Medical Center, Dallas, TX
*Purpose: Bronchiolitis obliterans (BOS) remains a major cause of death for lung transplant recipients, and the mechanisms that drive BOS remain poorly understood and require…