Am J Transplant, Volume 20, Suppl 3 Archives - Page 81 of 223 - ATC Abstracts

2020 American Transplant Congress
Long-term Functional Survival of Human Stem Cell-Derived Islets Microencapsulated in Alginate with CXCL12 in Non-Human Primates without Immunosuppression
M. C. Poznansky¹, D. Alagpulinsa¹, J. Lei², R. Pop³, D. Sobell⁴, M. Chapin¹, S. Collins³, A. Veres³, H. Deng², D. Melton³, J. Markmann²
¹Vaccine and Immunotherapy Center, Massachusetts General Hospital, Charlestown Navy Yard, MA, ²Transplant Surgery, Massachusetts General Hospital, Boston, MA, ³Harvard Stem Cell Institute, Harvard University, Cambridge, MA, ⁴Vaccine and Immunotherapy Center, Massachusetts General Hospital, Boston, MA
*Purpose: Human pluripotent stem cell-derived islet-like cells (SC-islets) represent a practical source for beta-cell replacement to achieve a functional cure for type 1 diabetes. Long-term…
2020 American Transplant Congress
Improving Eligibility of Renal Transplants in the Elderly
L. B. Moraitis¹, J. Rogers², A. Farney¹, A. Reeves-Daniel¹, G. Orlando¹, W. Doares¹, S. Kaczmorski¹, A. Mena-Gutierrez¹, C. Jay¹, R. Stratta¹
¹Abdominal Organ Transplant, Wake Forest Baptist Health, Winston-Salem, NC, ²Surgery, Wake Forest Baptist Health, Winston-Salem, NC
*Purpose: In the recent past, older age was a contraindication to kidney transplantation (KT). New kidney allocation schemes with use of longevity matching, initiation of…
2020 American Transplant Congress
Low Diagnostic Yield of Protocol Allograft Biopsy Performed During DGF in Deceased Donor Kidney Transplant Recipients Treated with Induction and Standard-Dose CNI-Based Maintenance
E. Favi¹, A. James², M. Ferraresso¹, R. Cacciola³
¹Renal Transplantation, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy, ²Renal Transplantation, Royal London Hospital, London, United Kingdom, ³HBP and Transplant Unit, Tor Vergata University, Rome, Italy
*Purpose: DGF after kidney transplantation (KTx) has been associated with an increased risk of rejection. For this reason, clinical guideline recommends weekly allograft biospy (Bx)…
2020 American Transplant Congress
A Single-Center Characterization of the Living Liver Donor Evaluation Process
L. R. Herbst, A. D. Love, M. Krach, Y. Yu, L. Kurman, A. Gurakar, M. Hammami, A. M. Cameron, J. Garonzik Wang
Department of Surgery, Johns Hopkins University, Baltimore, MD
*Purpose: We have previously characterized the living kidney donor evaluation and found that African American (AA) donors were less likely to progress through the process…
2020 American Transplant Congress
Maintenance Belatacept Therapy is Associated with Increased Rates of Polyoma Viremia
D. Conti, E. Maciera, D. Pluckrose, M. Garner, D. Schuster, S. Patel
Albany Medical Center, Albany, NY
*Purpose: The introduction of belatacept costimulatory blockade therapy has added a novel and powerful agent to the immunosuppressive armamentarium utilized after renal transplantation. However, limited…
2020 American Transplant Congress
Total Penis, Scrotum, and Lower Abdominal Wall Transplant: 18-Month Update
D. S. Cooney¹, C. M. Cooney¹, V. Javia¹, J. T. Shores¹, A. L. Burnett², T. J. Bivalacqua², G. Brandacher¹, R. J. Redett¹
¹Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, ²Urology, Johns Hopkins University School of Medicine, Baltimore, MD
*Purpose: In 2018 we performed a total penis, scrotum, and lower abdominal wall transplant on a man who had sustained a loss of his bilateral…
2020 American Transplant Congress
Hypothermic Machine Perfusion Can Improve Hypoxia Tolerance in Human Discarded Liver
T. Ito, K. Kadono, H. Kojima, S. Kageyama, H. HIrao, K. Nakamura, K. J. Dery, A. E. Murray, J. Aziz, R. W. Busuttil, J. Kupiec-Weglinski, F. M. Kaldas
The Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA
*Purpose: The wider use of livers from expanded criteria donors may help improve access to liver transplantation (LT). Normothermic machine perfusion in LT has been…
2020 American Transplant Congress
Single Cell Gene Profiling Highlights Novel B Cell Populations Associated with the Development of Bronchiolitis Obliterates Syndrome after Lung Transplantation
N. F. Smirnova¹, K. Riemondy², S. Collins¹, J. Hesselberth², O. Eickelberg¹
¹Dept of Medicine - Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado - Anschutz Medical Campus, Aurora, CO, ²University of Colorado - Anschutz Medical Campus, Aurora, CO
*Purpose: The occurence of bronchiolitis obliterans syndrome (BOS) accounts for a poor long term prognosis after lung transplantation (LTx). Despite immunosuppressive T cell-targeting therapies the…
2020 American Transplant Congress
Creation of a Low-Cost Kidney Transplant Surgery Simulator and Survey of its Utility for Education
V. Melkonian, T. Huy, C. Varma, M. Nazzal, H. Randall, M. Nguyen
Department of Surgery, Saint Louis University, Saint Louis, MO
*Purpose: Surgical skills education in transplant surgery is challenging as center-specific outcomes are scrutinized and trainees’ exposure to the sub-specialty is decreasing. Simulation could overcome…
2020 American Transplant Congress
Anti-HLA IgM Antibodies are Unaffected by Imlifidase (IdeS) Treatment
A. Runström¹, R. Bockermann¹, K. Sjöholm¹, K. M. Roupé¹, Å. Schiött¹, L. Winstedt¹, C. Kjellman¹, T. Lorant²
¹Hansa Biopharma AB, Lund, Sweden, ²Section of Transplantation Surgery, Department of Surgical Sciences, Uppsala, Sweden
*Purpose: The immunoglobulin G (IgG)-degrading cysteine protease, imlifidase (IdeS) is an IgG endopeptidase under development as a rapid desensitization treatment in kidney transplantation. Imlifidase is…