Am J Transplant, Volume 20, Suppl 3 Archives - Page 80 of 223 - ATC Abstracts

2020 American Transplant Congress
Is it Time for Immune Screening for Belatacept-Treated Stable Kidney Transplant Patients for Adjust the Immunosuppression?
M. C. Rial¹, F. Caro², N. Ambrosi², D. Guerrieri², A. Calleri¹, E. Chuluyan¹, D. Casadei¹
¹ITAC, Buenos Aires, Argentina, ²CEFYBO, UBA, Buenos Aires, Argentina
*Purpose: Belatacept is a co-stimulation blocker for primary maintenance immunosuppression in kidney transplant recipients. The goal of this work was to study the immunological status…
2020 American Transplant Congress
Polyfunctional Cytokine Secreting Th17 Cells Preferentially Infiltrate Murine Renal Allografts with Acute Rejection and Are Associated with Elevated Th17: Treg Ratio
R. Dhital¹, V. Velazquez¹, Q. Zeng², M. Shimamura¹
¹Center for Vaccines and Immunity, Nationwide Children's Hospital, Columbus, OH, ²Center for Cardiovascular Research, Nationwide Children's Hospital, Columbus, OH
*Purpose: Our group has shown that renal transplant patients with acute rejection have elevated blood mRNA RORγt: FOXP3 ratio compared to patients with stable graft…
2020 American Transplant Congress
Human Organ Culture: A Novel Method for Evaluation of Reperfusion Injury in Human Kidney
J. T. Langford¹, C. Edwards¹, J. DiRito², M. Harris¹, S. A. Hosgood³, M. L. Nicholson³, J. S. Pober⁴, D. Haakinson¹, G. T. Tietjen¹
¹Department of Surgery, Yale School of Medicine, New Haven, CT, ²Department of Biomedical Engineering, Yale University, New Haven, CT, ³Department of Surgery, University of Cambridge, Cambridge, United Kingdom, ⁴Department of Immunobiology, Yale School of Medicine, New Haven, CT
*Purpose: Evaluate the ability of human organ culture to assess protein secretion during a model of reperfusion injury.*Methods: Biopsies are obtained from transplanted-declined human kidneys…
2020 American Transplant Congress
Neonatal Tolerance Induction: Behaviours of Allogeneic Spleen and Bone Marrow Inocula in Neonatal Mice are Largely Determined by the Nature of Their CD8 T Cells
R. A. Bascom, K. Tao, L. J. West
University of Alberta, Edmonton, AB, Canada
*Purpose: Injected adult allo-spleen (SC) and bone marrow cells (BMC) traffic to secondary lymphoid organs, proliferate and spread throughout neonatal mice; allo-SC consistently cause acute…
2020 American Transplant Congress
Why Donate to a Stranger? Exploring the Major Motivations of 31 Non-Directed (Altruistic) Living Kidney Donors
A. Maghen¹, G. Mendoza¹, S. E. Connor¹, S. Nassiri¹, L. Kwan¹, E. L. Wood¹, J. Lalezari¹, S. Friedman¹, S. George², S. L. Maliski³, J. L. Veale¹
¹Urology, David Geffen School of Medicine at UCLA, Los Angeles, CA, ²Community Health Sciences, UCLA Fielding School of Public Health, Los Angeles, CA, ³Office of the Dean, University of Kansas Medical Center School of Nursing, Kansas City, KS
*Purpose: With the steady increase in the number of non-directed donors (NDDs) in the U.S. in the past decade, understanding their motivations may help better…
2020 American Transplant Congress
Enhancing Kidney Allograft Decision Making: An Organ Offer Simulation Study
J. Mansy¹, J. Case¹, D. Stewart², H. McGehee², K. Lindblad², R. Schaffer¹, J. Fisher¹, J. Rice¹, S. Kurian¹, C. Marsh¹
¹Scripps Center for Organ and Cell Transplantation, La Jolla, CA, ²United Network for Organ Sharing Research Department, Richmond, VA
*Purpose: This study was designed to identify opportunities to improve UNOS organ allocation as well as providers’ decision-making process for cadaveric kidney offers. Using its…
2020 American Transplant Congress
Serum αKlotho after Living Kidney Donation: A Systematic Review and Meta-Analysis
W. Cheungpasitporn¹, C. Thongprayoon², N. Leeaphorn³, M. A. Mao⁴, J. A. Neyra⁵
¹Nephrology, University of Mississippi Medical Center, Jackson, MS, ²Nephrology and Hypertension, Mayo Clinic, Rochester, MN, ³Renal Transplant Program, University of Missouri-Kansas City School of Medicine/Saint Luke's Health System, Kansas City, MO, ⁴Nephrology and Hypertension, Mayo Clinic, Jacksonville, FL, ⁵Nephrology, University of Kentucky, Lexington, KY
*Purpose: αKlotho (klotho) is a known anti-aging protein that exerts diverse physiological effects. Defect in klotho gene expression in mice can result in a syndrome…
2020 American Transplant Congress
Reverse Epidemiology and the Obesity Paradox for Patients with Chronic Kidney Disease
R. A. Choudhury¹, D. Yoeli¹, H. B. Moore¹, H. Yaffe¹, G. Hoeltzel², K. R. Dumon³, N. N. Williams³, P. L. Abt⁴, K. D. Conzen¹, T. L. Nydam¹
¹Department of Surgery- Division of Transplantation Surgery, University of Colorado Hospital, Aurora, CO, ²Thomas Jefferson University Hospital, Philadelphia, PA, ³University of Pennsylvania Hospital, Philadelphia, PA, ⁴Department of Surgery- Division of Transplantation Surgery, University of Pennsylvania Hospital, Philadelphia, PA
*Purpose: Obesity has been associated with both increased progression of chronic kidney disease as well as with a paradoxical improvement in survival among ESRD patients…
2020 American Transplant Congress
Clazakizumab (Anti-IL-6 Monoclonal) as an Agent to Reduce Donor Specific Hla Antibodies (DSA) and Improve Outcomes in Patients with Chronic & Active Antibody-Mediated Rejection Post-Kidney Transplantation (NCT03380377)
S. C. Jordan, N. Ammerman, M. Toyoda, S. Ge, E. Huang, A. Peng, S. Sethi, R. Najjar, E. Ortiz, M. Chu, A. De Guzman, I. Kim, K. Lim, J. Choi, A. Vo
Cedars Sinai Medical Ctr, Los Angeles, CA
*Purpose: Highly sensitized (HS) patients are at an increased risk for chronic antibody mediated rejection (cABMR) and graft loss due to persistent, deleterious DSA production.…
2020 American Transplant Congress
Multi- National Survey among Nephrologists & Transplant Surgeons About the Suitability and Acceptance of the Marginal Live Kidney Donors with Sickle Cell Trait
Z. Arabi¹, A. Mateen¹, A. Altheaby¹, M. Bukhari², A. Hamad³, S. Kaysi⁴, E. Elhassan¹
¹KAMC, Riyadh, Saudi Arabia, ²Taif University, Taif, Saudi Arabia, ³The Regional Medical Center, Orangeburg, SC, ⁴CHU Clermont-Ferrand, Saint Pryv/ Saint Mesmin, France
*Purpose: Due to organ shortage, many transplant centers may consider “marginal” kidney donors as those with sickle cell trait ( SCT) for donation. Acceptance of…