Am J Transplant, Volume 20, Suppl 3 Archives - Page 76 of 223 - ATC Abstracts

2020 American Transplant Congress
Early Pancreas Allograft Failure is Associated with Donor Hypertension
C. Masset¹, J. Branchereau¹, L. Badet², C. Kerleau¹, C. Legendre³, D. Glotz⁴, G. Karam¹, D. Cantarovich¹
¹University Hospital of Nantes, Nantes, France, ²University Hospital of Lyon, Lyon, France, ³Necker Hospital, Paris, France, ⁴Saint Louis Hospital, Paris, France
*Purpose: About 10% of pancreas allografts are lost prematurely due to thrombosis. Despite identification of numerous risk factors, the incidence of early failure did not…
2020 American Transplant Congress
Normothermic Machine Perfusion of Genetically Modified Pig Livers with Human Blood
D. Detelich¹, T. M. Coe², C. G. Rickert², C. Carroll², N. Serifis², R. Matheson², I. Rosales², W. Qin³, Y. Kan³, J. Layer³, M. Youd³, W. Westlin³, S. Kimura², A. Azimzadeh², L. Yang³, J. F. Markmann²
¹Tufts Medical Center, Boston, MA, ²Massachusetts General Hospital, Boston, MA, ³eGenesis, Cambridge, MA
*Purpose: Barriers to pig-to-human liver xenotransplantation remain, including profound thrombocytopenia, coagulopathy, and rejection. We utilized ex-vivo liver xenoperfusion with human blood to study the human…
2020 American Transplant Congress
HLA Mismatch Immunogenicity: Are We Predicating Mismatches That Induce De Novo DSA Development or That Do Not?
V. Jucaud¹, L. Rebellato², K. Briley², C. Haisch², S. Kendrick³, H. Jones³, K. Mclawhorn³, D. Leeser², M. Everly¹
¹Terasaki Research Institute, Los Angeles, CA, ²East Carolina University, Greenville, NC, ³Eastern Nephrology Associates, Greenville, NC
*Purpose: Although the development of de novo donor-specific anti-HLA antibodies (dnDSA) remains a major risk factor for poor long-term kidney allograft outcomes, the prediction of…
2020 American Transplant Congress
Chronic Diarrhea in Renal Transplant Recipients: A Metagenomic Study of Gut Microbiota Composition and Functionality
J. C. Swarte¹, R. M. Douwes¹, S. Hu², R. Gacesa², H. J. Harmsen³, R. K. Weersma², S. J. Bakker¹
¹Internal Medicine - Nephrology, University Medical Centre Groningen, Groningen, Netherlands, ²Gastroenterology and Hepatology, University Medical Centre Groningen, Groningen, Netherlands, ³Medical Microbiology, University Medical Centre Groningen, Groningen, Netherlands
*Purpose: Chronic diarrhea is a common problem in renal transplant recipients (RTR) and can lead to a lower quality of life. However, in many patients…
2020 American Transplant Congress
Relapse-Prone Unresectable Hepatoblastoma (HB) Requiring Liver Transplantation (LT) Are Immunogenic and May Be Sensitive to Immune Checkpoint Inhibitors
M. Ningappa¹, C. Ashokkumar¹, J. Garifallou², M. Gonzalez², H. Hakonarson², S. Ranganathan¹, B. W. Higgs¹, R. Sindhi¹
¹Pediatric Transplant, Pittsburgh, PA, ²Children's Hospital of Philadelphia, Philadelphia, PA
*Purpose: Unresectable HB accounts for 8% of all pediatric LT. Post-LT relapse rates approach 20% indicating a need for more effective neoadjuvant chemotherapy.*Methods: To discover…
2020 American Transplant Congress
Metformin Improves Biomarkers of Calcineurin Inhibitor Related Nephrotoxicity
M. R. Fernando, K. Taylor, S. Herath, A. Au, J. Erlich, Z. Endre
Department of Nephrology, Prince of Wales Hospital, Randwick, Australia
*Purpose: Calcineurin Inhibitors (CNIs) prevent transplant rejection but cause significant nephrotoxicity. Biomarkers of CNI nephrotoxicity could help drug dosing and improve long-term graft outcomes. As…
2020 American Transplant Congress
Single-Cell Transcriptional Profiling Reveals Cellular Diversity and Intercommunication During Cardiac Allograft Rejection in the Mouse Heart Transplantation
Y. Tang, X. Shi, X. He
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
*Purpose: Allograft rejection is still the leading causes of the graft loss, especially long-term outcome. Single-cell genomics techniques are revolutionizing our ability to comprehensively characterize…
2020 American Transplant Congress
Changes in Gut Microbiota and Acute Rejection after Kidney Transplantation
H. Cho¹, J. Kim², H. Kim², J. Park³, M. Kwak⁴, B. Kim⁴, D. Kim², J. Lee⁵, B. Kim⁶, H. Lee²
¹Department of Internal Medicine, Chungbuk National University Hospital, Cheongju, Korea, Republic of, ²Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of, ³Department of Internal Medicine, Kangwon National University Hospital, Chuncheon, Korea, Republic of, ⁴ChunLab Inc. Seoul National University, Seoul, Korea, Republic of, ⁵Department of Internal Medicine, Seoul National University Boramae Hospital, Seoul, Korea, Republic of, ⁶Department of Life Science, Multidisciplinary Genome Institute, Hallym University, Chuncheon, Korea, Republic of
*Purpose: Kidney transplantation (KT) is the best treatment for end-stage renal disease. Although rejection is a normal immune response of the body to a foreign…
2020 American Transplant Congress
Mitochondrial Metabolism is Enriched Following Normothermic Ex-Vivo Kidney Perfusion of Grafts Procured Following Cardiac Death
P. Urbanellis¹, C. McEvoy¹, L. Mazilescu¹, S. Ganesh¹, R. John¹, I. Mucsi¹, A. Ghanekar¹, D. Bagli², A. Konvalinka¹, L. Robinson², M. Selzner¹
¹University Health Network, Toronto, ON, Canada, ²The Hospital for Sick Children, Toronto, ON, Canada
*Purpose: Normothermic ex-vivo kidney perfusion (NEVKP) preservation has demonstrated superior graft outcomes for kidneys procured following donation-after-cardiac death (DCD) over static cold storage (SCS). To…
2020 American Transplant Congress
Outcomes of Kidney Donors with Impaired Fasting Glucose and Diabetes
S. Hebert, D. T. Nguyen, E. A. Graviss, H. E. Adrogue, A. Gaber, A. Matas, H. Ibrahim
Houston Methodist Hospital, Houston, TX
*Purpose: Many kidney donor candidates with impaired fasting glucose (IFG) and all candidates with diabetes (DM) are excluded from donation. The diagnostic thresholds for IFG…