Am J Transplant, Volume 20, Suppl 3 Archives - Page 74 of 223 - ATC Abstracts

2020 American Transplant Congress
Outcomes of Successive Pregnancies in Kidney Transplant Recipients
S. Rao¹, L. Coscia², S. Constantinescu³, M. J. Moritz⁴
¹Medicine, University of Virginia Heath System, Charlottesville, VA, ²Transplant Pregnancy Registry International, Philadelphia, PA, ³Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, ⁴Surgery, Lehigh Valley Health Network, Allentown, PA
*Purpose: Pregnancy after transplant is considered high risk; nevertheless female kidney transplant (KT) recipients may have several post-transplant pregnancies. The aim of this study was…
2020 American Transplant Congress
BAFF Inhibition to Prevent Antibody Rebound Following Proteasome Inhibitor-Based Desensitization: A Randomized, Controlled Trial
S. Tremblay¹, A. Rike-Shields², A. Govil¹, M. Cardi³, P. Brailey¹, R. Alloway¹, E. Woodle¹
¹U Cincinnati, Cincinnati, OH, ²Surgery, U Cincinnati, Christ Hospital, Cincinnati, OH, ³Christ Hospital, Cincinnati, OH
*Purpose: Proteasome inhibitor (PI) therapy reduces bone marrow plasma cells and HLA antibodies (Abs) in renal transplant candidates. However, rebound is common in many patients…
2020 American Transplant Congress
Renal Function Parameters Improve PELDs Prediction of 90-day Death or Deterioration
L. Thalji¹, N. Thalji², D. Haile¹, J. Heimbach², S. Ibrahim³, P. Kamath⁴, D. Kor¹
¹Anesthesiology, Mayo Clinic, Rochester, MN, ²Surgery, Mayo Clinic, Rochester, MN, ³Pediatric Gastroenterology, Mayo Clinic, Rochester, MN, ⁴Gastroenterology, Mayo Clinic, Rochester, MN
*Purpose: Reliance upon exception points to prioritize children for liver transplantation (LT) stems from concerns that the Pediatric End-Stage Liver Disease (PELD) score underestimates mortality.…
2020 American Transplant Congress
Outcomes in Liver Transplantation with Use of Granulocyte-Colony Stimulating Factor
K. Schnelle, A. Leino, M. Chunduru, L. Von Stein, O. Witkowsky
The Ohio State Wexner Medical Center, Columbus, OH
*Purpose: Questions remain if treatment with a granulocyte-colony stimulating factor (G-CSF) impacts clinical outcomes after liver transplant. The purpose of this study was to compare…
2020 American Transplant Congress
Unexpected Regulation of Foxp3+ Treg Production, Stability and Function by the Nuclear Co-Repressor, Sin3A
L. M. Christensen¹, T. Akimova², R. Han¹, L. Wang¹, A. Samanta¹, W. W. Hancock²
¹Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, ²Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA
*Purpose: Foxp3+ T-regulatory (Treg) cells are crucial to immune homeostasis and self-tolerance, but the contributions to Tregs of the 4 large, multiprotein nuclear complexes (Sin3,…
2020 American Transplant Congress
Co-Stimulatory Blockade Immunosuppression Facilitates Lung Allograft Acceptance Through an Increase in Local IL-5 Production by Type 2 Innate Lymphoid Cells
Y. Guo, Z. Mei, A. Hata, B. Mahgoub, D. Li, A. Manafi, A. Banerjee, A. Gelman, D. Kreisel, A. Krupnick
Surgery, University of Virginia, Charlottesville, VA
*Purpose: We have recently demonstrated that co-stimulatory blockade (CSB)-induced mouse lung allograft acceptance depends on a rapid influx of eosinophils that function to downregulate T…
2020 American Transplant Congress
Eplet Mismatch Not Correlated with Antibody Mediated Rejection or Allograft Loss Among Kidney Transplant Recipients with De Novo Donor Specific Antibody
A. Basu¹, W. Jiqiu², A. Bentall², M. Gandhi², B. Dukek², N. Henderson², C. Schinstock²
¹Emory Healthcare, Atlanta, GA, ²Mayo Clinic, Rochester, MN
*Purpose: Eplet mismatches are associated with development of de novo DSA (dnDSA) in kidney transplant recipients. However, it remains unclear how the degree of eplet…
2020 American Transplant Congress
Normothermic Machine Perfusion of Extended Criteria Donor Livers: Identification of Protein Biomarkers Predictive of Graft Viability and Post-Transplant Complications
L. L. Wallace¹, J. Attard¹, Y. Boteon¹, R. Laing¹, J. Yu², T. Perera³, D. Mirza³, H. Mergental³, S. Afford¹
¹Centre for Liver and Gastrointestinal Research, University of Birmingham and the NIHR Biomedical Research Centre, UHB NHS Foundation Trust, Birmingham, United Kingdom, ²School of Biosciences, Advanced Mass Spectrometry Facility, University of Birmingham, Birmingham, United Kingdom, ³Liver Unit, The Queen Elizabeth Hospital, Birmingham, United Kingdom
*Purpose: The Viability Testing and Transplantation of mArginal donor Livers Clinical Trial (VITTAL) demonstrated the capacity of Normothermic Machine Perfusion (NMP) to increase the proportion…
2020 American Transplant Congress
The Experience of 1000 Cases of Hand Assisted Laparoscopic Donor Nephrectomy for Living Donor Kidney Transplantation
T. Hiramitsu¹, T. Tomosugi¹, K. Futamura¹, M. Okada¹, N. Goto¹, S. Narumi¹, K. Uchida², Y. Watarai¹
¹Nagoya Daini Red Cross Hospital, Nagoya Aichi, Japan, ²Masuko Memorial Hospital, Nagoya Aichi, Japan
*Purpose: Due to the increasing number of kidney transplant candidates, living donor kidney transplantation becomes more necessary. For living donor kidney transplantation, safe and efficient…
2020 American Transplant Congress
Predicting Renal Graft Function Post Transplantation Using Clinical and Biological Features Supported by Machine Learning Algorithms
Y. Gao¹, Y. Cui¹, C. Kuscu², C. Kuscu², L. Gallon³, A. Bajwa², E. Akalin⁴, J. D. Eason², D. Maluf², V. Mas²
¹Department of Genetics, University of Tennessee Health Science Center, Memphis, TN, ²Dept of Surgery, Transplant Research Institute, James D. Eason Transplant Institute, University of Tennessee Health Science Center, Memphis, TN, ³Northwestern University, Chicago, IL, ⁴Albert Einstein Medical College, New York, NY
*Purpose: Predicting renal function post transplantation is a frequent challenge impacting physician decisions and patient quality of life. We aimed to develop a composite score…