Am J Transplant, Volume 20, Suppl 3 Archives - Page 73 of 223 - ATC Abstracts

2020 American Transplant Congress
Cyclo(His-Pro) Prevents Against Renal Injury Through Activating Nrf2-Mediated Pathway
J. Moon¹, Y. Kim¹, H. Jung², J. Kim¹, W. Ju³, H. Lee¹, J. Lee⁴, C. Lee⁵, D. Kim¹, Y. Kim¹, S. Yang⁶
¹Seoul National University Hospital, Seoul, Korea, Republic of, ²R&D Center, NovMetaPharma Co., Ltd, Pohang, Gyeongbuk, Korea, Republic of, ³Seoul National University Biomedical Research Institute, Seoul, Korea, Republic of, ⁴Nephrology Clinic, National Cancer Center, Goyang, Korea, Republic of, ⁵Cheju Halla General Hospital, Jeju-do, Korea, Republic of, ⁶Kidney Research Institute, Seoul National University College of Medicine, Seoul, Korea, Republic of
*Purpose: Cyclic(His-Pro) (CHP) is an endogenous cyclic dipeptide that has antioxidative, anti-inflammatory effect via Nuclear factor erythroid 2-related factor (Nrf2) pathway. Endogenous CHP is distributed…
2020 American Transplant Congress
Alemtuzumab and Associated Infectious and Transplant Outcomes in Renal Re-Transplant Patients
T. N. Harris
The Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC
*Purpose: The purpose of this study was to evaluate infectious and transplant outcomes exclusively in renal re-transplant patients who had received alemtuzumab for induction therapy.*Methods:…
2020 American Transplant Congress
Differences in Alemtuzumab Dosing Does Not Affect Early Kidney Transplant Outcomes
A. Pressley, R. Stratta, J. Rogers, A. Farney, G. Orlando, W. Doares, A. Reeves-Daniel, C. Jay
Wake Forest Baptist Health, Winston-Salem, NC
*Purpose: Alemtuzumab (Alem) is a widely used medication for induction therapy in kidney transplantation. However, there is limited evidence comparing outcomes with low versus high…
2020 American Transplant Congress
Ethical and Financial Consequences of Incidental Radiological Findings During Living Kidney Donor Evaluation
R. Mao, R. Kulkarni, C. Duran, H. Stevenson-Lerner, M. Mujtaba, J. Fair, M. Kueht
University of Texas Medical Branch, Galveston, TX
*Purpose: Living kidney donation (LKD) provides a unique situation in that diagnostic studies are ordered on a presumably healthy individual. Literature has shown that preoperative…
2020 American Transplant Congress
The Association between Timed-Up-and-Go Test and Montreal Cognitive Assessment on Outcomes of Renal Transplant Candidates
K. Bozhilov, L. Wong
Transplant Surgery, Queens Medical Center, Honolulu, HI
*Purpose: Patients with frailty who undergo renal transplantation (RT) have a higher incidence of delayed graft function and rehospitalization, however little is known about the…
2020 American Transplant Congress
Long-Term Outcomes for the Use of Native Small Capacity, Defunctionalized Bladders in Pediatric Kidney Transplantation
P. Vuong, A. Brubaker, L. Maestretti, W. Concepcion, A. Gallo
Stanford University Medical Center, Palo Alto, CA
*Purpose: Small capacity, defunctionalized urinary bladders present a challenge in pediatric kidney transplantation due to the inability to perform an adequate anti-reflux ureterocystostomy in a…
2020 American Transplant Congress
Early Impact of Interleukin-6 Blockade on the Distribution of Peripheral Blood Immune Cell Subpopulations – 3-Month Results of a Phase 2 Trial Evaluating Clazakizumab in Late Antibody-Mediated Rejection
K. A. Doberer¹, G. A. Boehmig¹, M. Streitz², S. Schlickeiser², F. Bauernfeind¹, A. Spittler³, B. Jilma⁴, F. Eskandary¹, E. Chong⁵, S. Schranz⁴, K. Budde⁶, M. Dürr⁶
¹Department of Medicine III, Medical University of Vienna, Vienna, Austria, ²Charité Universitätsmedizin Berlin, Institute of Medical Immunology, Berlin, Germany, ³Center of Translational Research, Medical University of Vienna, Vienna, Austria, ⁴Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria, ⁵Vitaeris Inc., Vancouver, BC, Canada, ⁶Division of Nephrology and Intensive Care, Charité Universitätsmedizin Berlin, Berlin, Germany
*Purpose: Interleukin-6 (IL-6) is considered to play a critical role within the multifacted pathophysiological process of antibody-mediated rejection (ABMR), including modulation of regulatory T cells…
2020 American Transplant Congress
A Single Nucleotide Polymorphism of Tweak Predicts Arterio- and Arteriolohyalinosis in Kidney Transplants and is Associated with Allograft Survival
A. Karolin¹, D. Thottan¹, J. Zinsli¹, S. Rudloff¹, U. Huynh-Do¹, V. Banz², T. Berney³, M. Pascual⁴, T. Müller⁵, P. d’Amico⁶, I. Binet⁷, D. Sidler¹
¹Nephrology and Hypertension, University Bern, Bern, Switzerland, ²University Bern, Bern, Switzerland, ³University Hospital Genevia, Genevia, Switzerland, ⁴University Hospital Lausanne, Lausanne, Switzerland, ⁵University Hospital Zurich, Zurich, Switzerland, ⁶Hospital St.Gallen, St.Gallen, Switzerland, ⁷University Hospital Basel, Basel, Switzerland
*Purpose: We have recently demonstrated that the TNF superfamily member is critical for the pathogenesis of Calcineurin Inhibitor Toxicity (CNT). CNT is a common side…
2020 American Transplant Congress
Late Conversion from Calcineurin Inhibitors to Belatacept in Kidney-Transplant Recipients Has a Significant Beneficial Impact on Glycemic Parameters
J. Noble, F. Terrec, T. Jouve, H. Neciri Bennani, P. Benhamou, P. Malvezzi, B. Janbon, D. Giovannini, L. Rostaing
Nephrology and Transplant Unit, CHU Grenoble, Grenoble, France
*Purpose: Calcineurin inhibitors (CNIs) and steroids are strongly associated with new-onset diabetes after transplantation (NODAT), worsening of pre-existing diabetes, and cardiovascular events. We assessed the…
2020 American Transplant Congress
The Link between Waitlist Mortality and Access to Transplant, an Imaginative Reality
R. Batra¹, D. Mulligan¹, D. Haakinson¹, S. Noreen², D. Stewart², G. Gan³, Y. Deng³, S. Kulkarni¹
¹Surgery, Yale University School of Medicine, New Haven, CT, ²UNOS, Richmond, VA, ³Yale University, New Haven, CT
*Purpose: Liver transplant waitlist mortality due to inadequate access to livers is the Achilles heel in liver transplantation in United States. This remains amongst the…