Am J Transplant, Volume 20, Suppl 3 Archives - Page 72 of 223 - ATC Abstracts

2020 American Transplant Congress
10-Year Experience Transplanting Very Highly Sensitized Patients with End Stage Renal Disease
J. Diaz¹, J. Kennedy², S. Chinnakotla³, P. Verghese⁴
¹Department of Surgery, University of Minnesota, Saint Paul, MN, ²University of Minnesota, Minneapolis, MN, ³Department of Surgery, University of Minnesota, Minneapolis, MN, ⁴Department of Pediatrics, Division of Pediatric Nephrology, University of Minnesota, Minneapolis, MN
*Purpose: Very highly sensitized (VHS) individuals (calculated reactive antigen (cPRA) ≥ 95%) have increased rejection risk which negatively impacts kidney transplant outcomes. Multiple strategies have…
2020 American Transplant Congress
Gene Expression Dynamics Demonstrate Perturbations in Innate and Adaptive Immunity in Kidney Transplantation Patients with Cytomegalovirus Viremia
R. Ahn, J. Schaenman, Z. Qian, V. Groysberg, M. Rossetti, A. Hoffmann, D. Gjertson, M. Deng, E. F. Reed
University of California Los Angeles, Los Angeles, CA
*Purpose: Cytomegalovirus (CMV) viremia and disease continues to cause significant morbidity and mortality in kidney transplant patients with clinical complications including organ rejection and death.…
2020 American Transplant Congress
The Impact of a Positive Crossmatch on KAS Patients and Organs
J. Lee¹, K. Sjöholm², C. Kjellman², T. Lorant², L. Winstedt², V. Nigro², K. M. Roupé², Å. Schiött², A. Runstrom², S. Taranto³, T. Baker³, D. Stewart³
¹Medical Affairs, Hansa Biopharma, Camas, WA, ²Hansa Biopharma, Lund, Sweden, ³UNOS, Richmond, VA
*Purpose: Evaluate the potential effects of offer refusals due to positive crossmatch (+XM) on both patients and re-allocated organs with a focus on waitlist outcomes,…
2020 American Transplant Congress
Cirrhosis-Driven Immune Dysfunction is Associated with Poor Response to DEB-TACE and Waitlist Dropout in Hepatocellular Carcinoma Patients While Awaiting Liver Transplantation
K. Nunez, T. Sandow, M. Hibino, A. Cohen, P. Thevenot
Ochsner Health System, New Orleans, LA
*Purpose: Hepatocellular carcinoma (HCC) recurrence after transplantation is associated with higher tumor grade on explant, failure to respond to DEB-TACE, and pretreatment lymphopenia. We prospectively…
2020 American Transplant Congress
Uremic Symptoms: A Patient-Reported Outcome That is Associated with Access to Kidney Transplantation and Waitlist Mortality among Kidney Transplant Candidates
K. Taylor¹, N. Chu², Z. Shi², E. Rosello³, S. Kunwar², P. Butz³, S. Norman⁴, D. Crews⁵, K. Greenberg⁵, D. Segev³, T. Shafi⁶, M. McAdams-DeMarco³
¹Johns Hopkins University School of Nursing, Baltimore, MD, ²Department of Surgery, Johns Hopkins School of Medicine, Baltimore, MD, ³Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, ⁴Division of Nephrology, University of Michigan, Ann Arbor, MI, ⁵Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁶Division of Nephrology, University of Mississippi Medical Center, Jackson, MS
*Purpose: Patient-reported symptoms of uremia - pruritis, anorexia and fatigue - reflect incomplete removal of uremic toxins by dialysis and are likely one of the…
2020 American Transplant Congress
Impact of Non-Active Hepatitis B after Renal Transplantation
M. G. Naik, W. Duettmann, M. Mayrdorfer, F. Halleck, K. Budde, M. Duerr
Medical Department, Division of Nephrology and Internal Intensive Care Medicine, Charité, Berlin, Germany
*Purpose: Hepatitis B (HB) is more frequent in dialysis patients (pts) than in the general population. Patient and graft survival in pts with chronic HB…
2020 American Transplant Congress
Role of B-Cell Subsets in Allograft Rejection in Intestinal Transplantation
H. Dhani, N. Svetlicky, J. Kang, S. Moturi, A. Duttargi, K. Khan, C. Matsumoto, T. Fishbein, A. Kroemer
Transplant Institute, MedStar Georgetown University, Washington, DC
*Purpose: While B-cells contribute to allograft rejection by presenting antigens to T-cells and by producing donor-specific antibodies (DSAs) and various cytokines, their pathophysiology in transplant…
2020 American Transplant Congress
Early Post-Transplant Infusion of Ex Vivo-Expanded Autologous Polyclonal Regulatory T Cells (Treg) Prolongs Kidney Allograft Survival in Non-Lymphodepleted, CTLA4Ig-Treated Rhesus Monkeys
K. Sasaki, Y. Wang, R. Nakano, L. Lu, J. Hughes, V. Vujevich, A. J. Ganoza, M. Wijkstrom, A. Humar, A. W. Thomson, M. B. Ezzelarab
Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA
*Purpose: Rodent studies have demonstrated the utility of regulatory T cell (Treg) infusion for the promotion of tolerance to organ allografts. Here, we evaluated the…
2020 American Transplant Congress
End-Hypothermic Oxygenated Machine Perfusion after Static Cold Storage versus Static Cold Storage Alone in Kidneys from Extended Criteria Brain-Dead Donors: An International Randomized Controlled Trial
P. Husen¹, C. Boffa², I. Jochmans³, C. Krikke⁴, L. Davies², H. Hofker⁴, J. Pirenne³, R. Ploeg², A. Paul¹
¹General, Visceral and Transplantation Surgery, University Hospital Essen, Essen, Germany, ²Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, ³University Hospitals Leuven, Leuven, Belgium, ⁴University Medical Center Groningen, Groningen, Netherlands
*Purpose: A prospective, randomized, single-blinded, multicenter trial comparing the effect of short-term 'in house' oxygenated hypothermic machine preservation (End-HMPO2) following static cold storage (SCS) versus…
2020 American Transplant Congress
Pulmonary Hypertension is Associated with Inferior Graft and Patient Survival after Kidney Transplantation
M. C. Nguyen, P. Chiang, J. Motter, D. Brennan, A. Massie, J. Garonzik-Wang, D. Segev, D. Segev
Johns Hopkins Hospital, Baltimore, MD
*Purpose: Pulmonary hypertension (PH) is increasingly recognized among patients with chronic kidney disease largely driven by left heart failure, high cardiac output, hypoxic lung diseases…