Am J Transplant, Volume 20, Suppl 3 Archives - Page 72 of 223 - ATC Abstracts

2020 American Transplant Congress
Pre-Renal Transplant Education and Psychosocial Evaluation Positively Impacts Post-Transplant Medication Adherence
M. Jesse¹, D. Kim¹, A. Patel¹, R. Patil¹, S. Bhavsar¹, S. Desai¹, K. Gartrelle¹, A. Eshelman¹, E. Fleagle¹, D. Nicholson¹, E. Clifton²
¹Henry Ford Health System, Detroit, MI, ²University of Michigan, Ann Arbor, MI
*Purpose: An essential element of the organ transplant evaluation process is the preparation of transplant candidates and their social supports. However, approaches to this process…
2020 American Transplant Congress
Role of APC Subsets in Rejection and Graft-Versus-Host-Disease in Intestinal Transplantation
H. Dhani, N. Svetlicky, J. Kang, S. Moturi, A. Duttargi, K. Khan, C. Matsumoto, T. S. Fishbein, A. Kroemer
Transplant Institute, MedStar Georgetown University, Washington, DC
*Purpose: Intestinal transplantation (ITx) is arguably the most immunogenic and complex organ transplantation, often accompanied with high rates of allograft rejection (AR) and graft-versus-host disease…
2020 American Transplant Congress
Treg-Lymphatic Interfaces: Unique Molecular Structures for Cell-Cell Interactions During Migration
C. M. Paluskievicz, W. Piao, Y. Xiong, J. S. Bromberg
U of Maryland, Baltimore, MD
*Purpose: To promote transplant tolerance, T regulatory cells (Treg) must enter the afferent lymphatic vasculature by migrating across lymphatic endothelial cells (LECs), and then home…
2020 American Transplant Congress
Exposure to Tacrolimus Trough Levels Below 6ng/ml During the First Year is Associated with Inferior Kidney Graft Survival
T. Agur, B. Rozen-Zvi, R. Rahamimov
Department of Nephrology and Hypertension, Rabin Medical Center, Petah Tikva, Israel
*Purpose: Accumulating data indicates that sub-therapeutic levels of calcineurin inhibitors are associated with long-term graft loss. However, while widely used tacrolimus (TAC) was shown to…
2020 American Transplant Congress
Glomerular Filtration Rate Based on Cystatin C Provides the Best Prediction of Cardiovascular Events and Mortality Compared to Measured GFR and Creatinine Based GFR in Kidney Transplant Recipients
L. Galapia¹, J. Lieske², A. Rule², H. Amer², N. Zhang¹, D. Butterfield¹, M. Keddis¹
¹Mayo Clinic, Scottsdale, AZ, ²Mayo Clinic, Rochester, MN
*Purpose: GFR estimated by cystatin C (CysC) is a better predictor of cardiovascular (CV) events and mortality compared to eGFR by creatinine (Cr) in native…
2020 American Transplant Congress
Predonation Hypertension and Early Postdonation Systolic Blood Pressure among Older Living Kidney Donors
F. Al Ammary¹, A. D. Muzaale², D. C. Brennan¹, D. L. Segev², A. B. Massie²
¹Medicine, Johns Hopkins University, Baltimore, MD, ²Surgery, Johns Hopkins University, Baltimore, MD
*Purpose: One mechanism underlying predonation hypertension in older (age≥50) living kidney donors is a reduced number of nephrons. The 50% nephron mass reduction associated with…
2020 American Transplant Congress
Safety and Immunogenicity of Adjuvanted Recombinant Subunit Herpes Zoster Vaccine in Lung Transplant Recipients
C. Hirzel¹, V. H. Ferreira¹, A. G. L’Huillier¹, T. Ku¹, M. Ierullo¹, C. Miao², D. S. Schmid², J. Tikkanen¹, L. G. Singer¹, A. Humar¹, D. Kumar¹
¹University Health Network, Toronto, ON, Canada, ²CDC, Atlanta, GA
*Purpose: The new adjuvanted subunit recombinant herpes zoster vaccine (RZV; Shingrix™) may have potential utility in transplant patients for the prevention of shingles, but there…
2020 American Transplant Congress
Did the 250 Nautical Mile Circle Work? Geographic Disparities in Lung Transplantation Before and after the Policy Change
M. Kosztowski¹, Y. Yu², A. Massie², D. L. Segev², S. E. Gentry²
¹University of Iowa, Iowa City, IA, ²Johns Hopkins, Baltimore, MD
*Purpose: In November 2017, the lung allocation policy was challenged in court due to concern that candidates living in New York City were being disadvantaged…
2020 American Transplant Congress
Intravenous Administration of Mitochondria Minimizes Liver Ischemia Reperfusion Injury in Lean and Diet Induced Obese Mice
T. Rousselle¹, E. Patterson¹, C. Kuscu¹, J. Pierre², C. Kuscu¹, J. Eason¹, D. Maluf¹, V. Mas¹, A. Bajwa¹
¹Dept of Surgery, Transplant Research Institute, James D. Eason Transplant Institute, University of Tennessee Health Science Center, Memphis, TN, ²Dept of Pediatrics, UTHSC, Memphis, TN
*Purpose: Ischemia induces altered bioenergetics within cells with increased mitochondrial swelling and reactive oxygen species and that ultimately degrade of cellular function. Ischemia reperfusion injury…
2020 American Transplant Congress
Long-term Functional Survival of Human Stem Cell-Derived Islets Microencapsulated in Alginate with CXCL12 in Non-Human Primates without Immunosuppression
M. C. Poznansky¹, D. Alagpulinsa¹, J. Lei², R. Pop³, D. Sobell⁴, M. Chapin¹, S. Collins³, A. Veres³, H. Deng², D. Melton³, J. Markmann²
¹Vaccine and Immunotherapy Center, Massachusetts General Hospital, Charlestown Navy Yard, MA, ²Transplant Surgery, Massachusetts General Hospital, Boston, MA, ³Harvard Stem Cell Institute, Harvard University, Cambridge, MA, ⁴Vaccine and Immunotherapy Center, Massachusetts General Hospital, Boston, MA
*Purpose: Human pluripotent stem cell-derived islet-like cells (SC-islets) represent a practical source for beta-cell replacement to achieve a functional cure for type 1 diabetes. Long-term…