Am J Transplant, Volume 20, Suppl 3 Archives - Page 59 of 223 - ATC Abstracts

2020 American Transplant Congress
Absence of Adverse Infectious Disease Outcomes in the Long-Term Follow-Up of Recipients of PHS Increased Risk Donor Organs: An Essential Tracking Program
L. Irwin, J. Fishman
Transplant Surgery, Massachusetts General Hospital, Boston, MA
*Purpose: 37-41% of deceased donors in Region I are considered “PHS increased risk for infectious disease transmission” (IR) individuals, our Center developed guidelines for the…
2020 American Transplant Congress
Gingival Mesenchymal Stem Cells (GMSCs) Mitigate Liver Ischemia-Reperfusion Injury by Regulating Macrophage Polarization Through miR-199a-3p
Y. Zhang, M. Chen, W. Ju, T. Wang, Z. Chen, C. Huang, R. Xie, Q. Zhao, Z. Guo, X. He
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
*Purpose: Mesenchymal stromal cells (MSCs) have been increasingly studied in organ ischemia-reperfusion injury, but the mechanism is still unclear. This study explored the immunoregulatory effects…
2020 American Transplant Congress
Lymph Node Stromal Laminin Alpha5 Regulates Antigen Specific T Cell Adaptive Immunity
L. Li¹, M. Shirkey¹, W. Piao¹, Y. Xiong¹, V. Saxena¹, T. Zhang¹, C. Paluskievicz¹, J. Zhao², R. Abdi², J. S. Bromberg¹
¹UMB, Baltimore, MD, ²Harvard University, Boston, MA
*Purpose: Laminin α5 (Lama5) is associated with immunity and regulates T cell entry and responses within the lymph node (LN). We hypothesized that stromal Lama5…
2020 American Transplant Congress
Simultaneous Heart Kidney Transplant Benefits are Concentrated in the Dialysis Dependent Population
B. I. Shaw¹, M. L. Samoylova¹, Z. W. Fitch¹, M. Bishawi¹, R. Schmitz¹, S. J. Kesseli¹, A. S. Barbas¹, C. B. Patel², S. L. Sanoff², L. M. McElroy¹
¹Surgery, Duke University, Durham, NC, ²Medicine, Duke University, Durham, NC
*Purpose: With ongoing growth of simultaneous organ transplant and increased attention to allocation policy, we examined trends in simultaneous heart-kidney (SHK) transplantation outcomes over the…
2020 American Transplant Congress
Decoding the Troubled Allograft: Proteinuria within the 1^st Post-Transplant Year Associates with and Risk Stratifies Inflamed Renal Transplants
A. Cherukuri, R. Mehta, A. Tevar, R. Munjal, K. Kalra, C. Puttarajappa, P. Sood, C. Wu, S. Hariharan
Starzl Transplantation Institute, UPMC, Pittsburgh, PA
*Purpose: The relationship between progression of proteinuria and allograft histology through the 1st year with clinical outcomes is unclear.*Methods: Here, we systematically studied proteinuria {early…
2020 American Transplant Congress
Paired Exchange Living Donor Liver Transplantation Using Compatible Pairs- U.S. Single Center Experience
T. Klair, D. Fritze, E. Thomas, G. Abrahamian, G. Halff, K. Speeg, F. Cigarroa
University of Texas Health San Antonio, San Antonio, TX
*Purpose: ABO and size incompatibility are common reasons for non-acceptance of otherwise suitable donors in Living Donor Liver Transplantation (LDLT). Paired exchange LDLT has been…
2020 American Transplant Congress
Center Effects Substantially Explain Disparities in Access to Kidney Transplants, Yet DSA Effects Remain
D. Stewart, A. Robinson, D. Klassen, A. Wilk
United Network for Organ Sharing, Richmond, VA
*Purpose: The OPTN developed a novel methodology in 2016 to monitor equity in access to deceased donor kidney transplants (Tx) among waitlisted candidates. Results have…
2020 American Transplant Congress
Genome-Wide Analysis of Epstein Barr Virus Identifies Variations in the Latency Gene EBNA3C That Are Associated with Post Transplant Lymphoproliferative Disorder
E. Maloney, J. Toh, S. M. Krams, C. O. Esquivel, O. M. Martinez
Stanford University Sch of Med, Stanford, CA
*Purpose: Epstein Barr virus (EBV) is a gamma herpes virus that is associated with a variety of human malignancies including EBV+ B cell lymphomas in…
2020 American Transplant Congress
Tissue Specificity and the Role of Lymphocytes in Estrogen-Mediated Protection from Renal Ischemia Reperfusion Injury
P. T. Hernandez, C. S. O'Brien, S. J. Concors, L. N. Krumeich, Z. Wang, G. Ge, W. Hancock, M. H. Levine
Hospital of the University of Pennsylvania, Philadelphia, PA
*Purpose: Renal ischemia reperfusion injury (IRI) is a major contributor to delayed graft function (DGF) in kidney transplantation. We previously demonstrated lower rates of DGF…
2020 American Transplant Congress
Tonic-Signaling Chimeric Antigen Receptors Drive Exhaustion in Regulatory T Cells
C. Lamarche¹, C. Mackall², E. Weber³, M. Levings⁴
¹University of British Columbia, Vancouver, BC, Canada, ²Stanford University School of Medicine, Standford, CA, ³Stanford University School of Medicine, Stanford, CA, ⁴Surgery, University of British Columbia and BC Children's Hospital Research Institute, Vancouver, BC, Canada
*Purpose: Regulatory T cells (Tregs) and chimeric antigen receptor (CAR) Tregs are a promising cell therapy to prevent or treat autoimmune diseases or allograft rejection.…