Am J Transplant, Volume 20, Suppl 3 Archives - Page 58 of 223 - ATC Abstracts

2020 American Transplant Congress
Automatic Quantification of Interstitial Fibrosis in Renal Allograft
J. Hogan¹, J. Vizcarra², M. A. Tageldin², L. A. Cooper³, D. A. Gutman², A. B. Farris⁴
¹Transplant Research Center, Department of Surgery, Emory University, Atlanta, GA, ²Computer Science Department, Emory University, Atlanta, GA, ³Pathology Department, Northwestern University, Evanston, IL, ⁴Pathology Department, Emory University, Atlanta, GA
*Purpose: Renal allografts are typically assessed by pathologists using the Banff classification with known interobserver variability. We previously demonstrated the utility of image analysis in…
2020 American Transplant Congress
Immunomodulation During Normothermic Ex Vivo Machine Perfusion of the Rat Liver
K. Carlson¹, F. Najmabadi¹, J. Pavan-Guimaraes¹, W. J. Burlingham¹, C. M. Capitini², D. P. Al-Adra¹
¹Surgery, University of Wisconsin, Madison, WI, ²Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI
*Purpose: Transplantation is the best treatment option for end-stage liver failure. There remains a critical need to develop targeted therapeutic strategies to decrease graft rejection…
2020 American Transplant Congress
FcγRIIIb Inhibits Renal Transplant Rejection by Inducing Neutrophils Apoptosis
J. Zhang, J. Chen
Kidney Disease Center, The First Affiliated Hospital of Zhejiang University, Hangzhou, China
*Purpose: Fcγ receptors (FcγR) have been proposed to be involved in the pathogenesis of acute rejection (AR) after organ transplantation. However, the mechanisms by which…
2020 American Transplant Congress
The Effect of Ex Vivo Preservation and Regulatory T Cells on the Development of Transplant Arteriosclerosis in a Humanized Mouse Model
A. Knoefel, T. Siemeni, F. Ius, W. Sommer, J. Salman, I. Tudorache, A. Haverich, C. Falk, G. Warnecke
MHH, Hannover, Germany
*Purpose: Lung transplantation is the last remaining option for treatment of end stage lung disease. Explanted lungs can be preserved using ex vivo lung perfusion…
2020 American Transplant Congress
Cardiac Allograft Tolerance Can be Achieved in Non-Human Primates via Transient Mixed Hematopoietic Chimerism and Erythropoietin Administration
K. Ahrens¹, J. M. O¹, W. Sommer², J. Morrissette¹, D. Becerra¹, P. M. Patel¹, A. Dehnadi¹, T. Costa¹, I. M. Hanekamp¹, J. S. Allan³, P. Cravedi⁴, P. S. Heeger⁴, G. Benichou¹, J. C. Madsen⁵
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany, ³Center for Transplantation Sciences, Division of Thoracic Surgery, Massachusetts General Hospital, Boston, MA, ⁴Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, ⁵Center for Transplantation Sciences, Division of Cardiac Surgery, Massachusetts General Hospital, Boston, MA
*Purpose: In non-human primates (NHPs), a mixed chimerism-based conditioning protocol results in kidney transplant tolerance and combined kidney and heart allograft tolerance. Previous work showed…
2020 American Transplant Congress
A Video Education Intervention to Improve Kidney Transplant Knowledge and Self-Efficacy in Dialysis Center End Stage Renal Disease (ESRD) Patients
D. A. DuBay¹, T. Morinelli¹, Z. Sutton¹, M. Chastain¹, T. Thompkins Tindal¹, Z. Su¹, E. Weeda¹, P. Mauldin¹, M. Casey¹, J. Bian¹, J. Rodrigue², P. Baliga¹, D. Taber³
¹Medical University of South Carolina`, Charleston, SC, ²Departments of Surgery and Psychiatry, Beth Israel Deaconiess Medical Center, Boston, MA, ³Department of Surgery, Medical University of South Carolina`, Charleston, SC
*Purpose: Only 34% of incident ESRD patients are referred for transplant (Tx) evaluation within 12 months of initiating dialysis. There is great need for effective…
2020 American Transplant Congress
The Eplet-Mismatch Landscape in Kidney Patients and Deceased Donors in British Columbia
J. Tran¹, O. Gunther², J. Lan¹, M. Kadatz¹, R. Sapir-Pichhadze³, P. A. Keown¹
¹University of British Columbia, Vancouver, BC, Canada, ²Gunther Analytics, Vancouver, BC, Canada, ³McGill University, Montreal, QC, Canada
*Purpose: Minimizing quantitative donor/recipient mismatch at the HLA epitope level may optimize graft outcomes in renal transplantation, but the degree to which optimal matching can…
2020 American Transplant Congress
Gross Morphological Score for Deceased Donor Kidneys Can Predict Delayed Graft Function in Kidney Transplant Recipients
M. Mandurah, M. A. Levine, A. Sener, P. Luke
Department of Kidney Transplantation, London Health Sciences Center, London, ON, Canada
*Purpose: Both microscopy and kidney donor profile index (KDPI) scoring systems have been used to predict kidney transplant outcomes. Utilizing gross renal morphology, we designed…
2020 American Transplant Congress
Proportion of Veillonella and the Risk of New-Onset Diabetes Mellitus after Kidney Transplantation
K. Ji Eun¹, H. Kim¹, H. Cho², J. Park³, J. Lee⁴, D. Kim¹, K. Joo¹, Y. Kim¹, H. Lee¹
¹Seoul National University Hospital, Seoul, Korea, Republic of, ²Chungbuk National University Hospital, Cheongju, Korea, Republic of, ³Kangwon National University Hospital, Chuncheon, Korea, Republic of, ⁴Seoul National University Boramae Hospital, Seoul, Korea, Republic of
*Purpose: New-onset diabetes transplantation after transplantation (NODAT) is an important metabolic complication after kidney transplantation, although its mechanism is not yet fully elucidated. Recent studies…
2020 American Transplant Congress
Anti-IL-6 Antibody Clazakizumab in Late Antibody-Mediated Rejection – Molecular Rebound Phenomena Under IL-6 Blockade?
A. Borski¹, S. Haindl², M. Duerr³, K. Budde³, S. Schranz¹, F. A. Eskandary², K. Doberer², P. F. Halloran⁴, E. Chong⁵, B. Jilma¹, G. A. Böhmig², M. Wahrmann²
¹Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria, ²Department of Medicine III, Medical University of Vienna, Vienna, Austria, ³Charité Universitätsmedizin Berlin, Berlin, Germany, ⁴University of Alberta, Edmonton, AB, Canada, ⁵Vitaeris Inc., Vancouver, BC, Canada
*Purpose: Late antibody-mediated rejection (ABMR) is well established as a major cause of kidney allograft failure. Targeting interleukin-6 (IL-6), a pro-inflammatory cytokine involved in B…