ATC Abstracts

American Transplant Congress abstracts

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  • 2020 American Transplant Congress

    Strong Engagement of CD137 Suppresses Graft-Versus-Host Disease Through Dendritic Cells

    H. Cho1, J. Lee2, B. Kwon3, S. Park4, H. Park4, K. Yoo2, K. Park2, J. Kim3, S. Kang3

    1Ulsan University Hospital, Ulsan, Korea, Republic of, 2Nephrology, Ulsan University Hospital, Ulsan, Korea, Republic of, 3Biomedical Research Center, Ulsan University Hospital, Ulsan, Korea, Republic of, 4Surgery, Ulsan University Hospital, Ulsan, Korea, Republic of

    *Purpose: We previously demonstrated that anti-CD137 agonist prevent acute graft-versus-host disease (GVHD) and chronic GVHD in the parent-into-unirradiated F1 acute or chronic GVHD model. Although…
  • 2020 American Transplant Congress

    Electroacupuncture Promotes Induction of Long-Term Allograft Survival by Enhancing Lymphatic Migration of CD4+Foxp3+ Tregs via Upregulating Their LTalpha1beta2 Expression

    H. Liu, Y. Chen, F. Qiu, Z. Dai

    Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China

    *Purpose: Induction of long-term transplant survival without continuous global immunosuppression is a highly desired goal in transplantation. Electroacupuncture (EA) has been shown to regulate immunity…
  • 2020 American Transplant Congress

    Inducing Donor MHC Chimerism with Bone Marrow Derived Exosomes in Non-Human Primates

    P. M. Patel1, B. A. Gonzalez Nolasco1, J. A. Morrissette1, A. Prunevieille1, K. J. Ahrens1, J. M. O1, D. C. Becerra1, G. Benichou1, J. C. Madsen2

    1Surgery, Center for Transplantation Sciences, Massachusetts General Hospital/Harvard Medical School, Boston, MA, 2Surgery, Center for Transplantation Sciences, Division of Cardiac Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, MA

    *Purpose: Cardiac allograft tolerance in non-human primates (NHPs) has been achieved by our group via hematopoietic mixed chimerism consisting of an allogeneic bone marrow (BM)…
  • 2020 American Transplant Congress

    Lymphycyte Subset Test as a Determinant of Cytomegalovirus Prophylaxis in Renal Transplant Recipients

    M. Kim, Y. Park, S. Mok, K. Jun, S. Kim, J. Kim, S. Yun, I. Moon, S. Park

    Surgery, The Catholic University of Korea, Seoul, Korea, Republic of

    *Purpose: Cytomegalovirus (CMV) infection is an important complication after kidney transplantation (KT). Anti-thymocyte globulin (ATG) increases a risk of CMV infection and the American society…
  • 2020 American Transplant Congress

    CD47 Innate Immune Checkpoint Enhances Islet Engraftment Following Intraportal Transplantation by Mitigating Instant Blood Mediated Inflammatory Reaction

    P. Shrestha, L. Batra, M. T. Malik, M. Tan, E. S. Yolcu, H. Shirwan

    Institute for Cellular Therapeutics and Department of Microbiology and Immunology, University of Louisville, Louisville, KY

    *Purpose: Transplantation of islets into hepatic portal vein is associated with significant islet mass loss immediate post-transplantation. Instant blood mediated inflammatory reaction (IBMIR), characterized by…
  • 2020 American Transplant Congress

    Allograft Repopulating Recipient B Cells after Human Intestinal Transplantation and Their Association with Donor Specific Antibody Secretion and Rejection

    E. Waffarn1, J. Fu1, K. Frangaj1, W. Meng2, A. M. Rosenfeld2, M. Li3, K. Rodgers1, R. Vasilescu3, E. T. Luning Prak2, A. Griesemer1, T. Kato4, M. Martinez5, M. Sykes1

    1Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY, 2Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, 3Department of Pathology, Columbia University, New York, NY, 4Department of Surgery, Columbia University, New York, NY, 5Department of Pediatrics, Columbia University, New York, NY

    *Purpose: Alloantibodies produced by recipient B cells are associated with rejection after intestinal transplantation (ITx) and negatively impact patient and graft survival. However, the dynamics…
  • 2020 American Transplant Congress

    UNOS Hard to Place Kidneys: Are We Working Too Hard?

    S. Chaudhry, K. L. King, S. A. Husain, D. Cohen, L. Ratner, S. Mohan

    Columbia University, New York, NY

    *Purpose: Kidneys requiring more than 100 offers before acceptance are defined by UNOS as “hard to place," but many are suitable for transplantation. We sought…
  • 2020 American Transplant Congress

    Optimal Timing of Renal Transplantation in Simultaneous Heart-Kidney Transplant: A Retrospective Analysis of the UNOS/OPTN Database

    A. S. Karim, G. E. Leverson, J. W. Smith, D. P. Foley

    Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI

    *Purpose: In patients receiving a simultaneous heart-kidney transplant (SHKT) the optimal timing of performing the kidney transplant remains controversial. In the immediate approach (iHKT), the…
  • 2020 American Transplant Congress

    2019 Refined Criteria for Cirrhotic Cardiomyopathy Predict Post Liver Transplant Cardiac Events

    M. J. Izzy1, A. Soldatova2, X. Sun2, M. Angirekula3, K. Mara4, G. Lin2, K. Watt3

    1Gastroenterology and Hepatology, Vanderbilt University Medical Center, Nashville, TN, 2Cardiovascular Medicine, Mayo Clinic, Rochester, MN, 3Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, 4Health Sciences Research, Mayo Clinic, Rochester, MN

    *Purpose: Cirrhotic cardiomyopathy (CCM) encompasses systolic ± diastolic dysfunction (DD) in patients with end stage liver disease in the absence of known cardiac disease. The…
  • 2020 American Transplant Congress

    Antibiotic Stewardship and Inpatient C. Difficile Testing in Solid Organ Transplant Recipients, the Value of Multi-Level Checks and Balances

    M. Kueht, R. Britt, R. Ferren, M. Mujtaba, R. Ramirez, R. Kulkarni, A. Lea, J. Fair, D. Reynoso

    University of Texas Medical Branch, Galveston, TX

    *Purpose: Diarrhea in the solid organ transplant recipient is a commonly encountered problem and is often multifactorial in etiology. Due to the combination of peri-operative…
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