Am J Transplant, Volume 20, Suppl 3 Archives - Page 46 of 223 - ATC Abstracts

2020 American Transplant Congress
Femto Pulse Analysis of Exosome RNA from Plasma of Renal Transplant Patients Confirmed the Unique Benefits of Plasma Exosome for Messenger RNA (mRNA) Transcript Analysis
H. Zhang¹, K. Wong², S. C. Jordan³, D. Warzak², M. Toyoda¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA, ²Agilent Technologies, Inc., Ankeny, IA, ³Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: Previously, we reported the feasibility of measuring the mRNA transcript levels of various genes in plasma exosomes of renal transplant patients for prediction of…
2020 American Transplant Congress
Abdominal Multiorgan Retrieval from Pigs in a Slaughterhouse: A Reliable and Efficient Donation after Circulatory Death Model for Ex Vivo Organ Perfusion
F. Neri, F. Dengu, G. Ebeling, L. Knijff, K. Rozemberg, J. Branchereau, P. Friend, R. Ploeg, J. Hunter
Nuffield Department of Surgical Sciences, Oxford University, Oxford, United Kingdom
*Purpose: Advances in organ perfusion technology have been driven by the increasing necessity to utilise organs from donors after circulatory death (DCD) and marginal donors.…
2020 American Transplant Congress
What Happens When You Administer Mesenchymal Stromal Cells During Normothermic Machine Perfusion of Porcine Kidneys: Possible and Helpful or Not?
K. Rozenberg¹, L. Knijff¹, J. Sierra-Parraga², L. Lo Faro¹, M. Hoogduijn², C. Baan², J. Hunter¹, R. Ploeg¹
¹Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, ²Department of Internal Medicine, Nephrology and Transplantation, Erasmus MC, University Medical Center, Rotterdam, Netherlands
*Purpose: Donation after circulatory death kidneys are widely used to increase the donor pool, despite their inferior quality. Normothermic machine perfusion (NMP) could provide a…
2020 American Transplant Congress
Characterization of a Novel CD8⁺ B Cell Subset in Monkeys Tolerant of Heart Allografts
J. A. Morrissette¹, K. Pruner¹, S. Lee¹, J. Paster¹, W. Sommer¹, J. O¹, I. Hanekamp¹, P. Sage², G. Benichou¹, J. C. Madsen³
¹Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA, ²Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ³Center for Transplantation Sciences, Division of Cardiac Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA
*Purpose: We have previously reported that transient mixed hematopoietic chimerism induced via donor bone marrow transplantation can achieve tolerance to cardiac allografts in non-human primates…
2020 American Transplant Congress
B Cell Derived IL-1β and IL-6 Drive Homeostatic T Cell Recovery Following Lymphoablation
S. Hasgur, R. Fan, A. Valujskikh
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: T cell reconstitution after lymphoablation in allograft recipients may lead to acute rejection and poor graft outcome. Using a mouse model of heart transplantation…
2020 American Transplant Congress
Investigation of Il35 Expressing Regulatory B Cells in Tolerance of Kidney Transplantation
J. A. Sullivan, J. H. Fechner, E. Jankowska-Gan, W. J. Burlingham, D. B. Kaufman
Surgery, University of Wisconsin, Madison, WI
*Purpose: The development and maintenance of peripheral tolerance is required for long term success of solid organ transplantation without immuno-suppressive drugs. Using a novel, post-transplant,…
2020 American Transplant Congress
Lack of Dj-1 Amplifies Sepsis-Associated Acute Kidney Injury and Increases Parenchymal Apoptosis
J. Leeds¹, Y. Scindia², E. Ghias¹, S. Cechova¹, V. Loi¹, E. Mandziak¹, S. Swaminathan¹
¹University of Virginia, Charlottesville, VA, ²University of Florida, Gainesville, FL
*Purpose: Sepsis following kidney transplantation is a frequent complication due to mandatory immunosuppression and increased infection risk. Kidney transplant recipients who develop sepsis show inferior…
2020 American Transplant Congress
Exosomes Containing Kidney Self-Antigens (Collagen Iv, Fibronectin, Perlecan) Predicts Progression of Chronic Immune Injury in Kidney Transplant Recipients
R. Ravichandran¹, Y. Itabashi¹, R. Heilman², A. Jaramillo², D. Ramon², M. Buras², B. Kaplan³, T. Mohanakumar¹, S. Sukumaran Nair²
¹St. Joseph’s Hospital, Phoenix, AZ, ²Mayo Clinic, Phoenix, AZ, ³Baylor Scott and White, Georgetown, TX
*Purpose: We have shown that circulating exosome with lung self-antigens (SAgs) are detectable 1 year prior to chronic lung allograft dysfunction, independent of circulating antibodies.…
2020 American Transplant Congress
UK Residents Transplanted Overseas: A Summary of UK Data from 2000-2016
A. Cronin¹, L. Mumford², M. Robb², L. Burnapp², R. Johnson²
¹Guy's and St. Thomas' Hospital, London, United Kingdom, ²NHS Blood and Transplant, Bristol, United Kingdom
*Purpose: Organ shortage has prompted UK residents to source organs overseas. Little is known about the circumstances in which these transplants take place, but stories…
2020 American Transplant Congress
Direct Acting Anti-Viral Prophylaxis to Prevent Virus Transmission from Hepatitis C Viremic Donors to Hepatitis C Negative Kideney Transplant Recipients
G. Gupta, I. Yakubu, D. Kumar, I. Moinuddin, L. Kamal, A. King, C. Bhati, A. Sharma, A. Cotterell, A. Khan, M. Levy, R. Sterling
Virginia Commonwealth University, Richmond, VA
*Purpose: Previous trials in kidney transplantation (KT) have described a 12-week course of direct-acting anti-viral drugs (DAA) to treat HCV transmission from infected donors to…