2020 American Transplant Congress
Multimodal Theranostic Nanocolloid Platform for Imaging, Targeted Drug Delivery and Organ Preservation in Transplantation
*Purpose: The goal of this project design and development of multifunctional nanomedicines to address unique and complex therapeutic outcomes in transplantation and organ preservation. Presented…2020 American Transplant Congress
Immune Response Following Cardiac Progenitor Cells Transplantation in Rat Myocardial Infarction Model
Surgery, University of Maryland, Baltimore, MD
*Purpose: Cardiac progenitor cells (CPCs, c-kit+) are well-characterized stem cell type shown to potentiate cardiac regeneration in myocardial infarct (MI) model. However, auto and allo…2020 American Transplant Congress
Concept Discussion: Five Experimental Stages to Establish the Methodologies for Organ Farming
George Washington University, Bristow, VA
*Purpose: Most of the technologies to grow human organs in vitro already exist, but experimentation (and policy development support) will be required to ensure that:*Methods:…2020 American Transplant Congress
HLA-Antibody Develops Preferentially in Healthy Subjects with a T-bethiB Cell Response to Vaccine
University of Alabama, Birmingham, AL
*Purpose: Bystander B cell differentiation into antibody (Ab) secreting cells (ASCs) may augment alloimmunity in the HLA-sensitized patient. Recently, a population of FcrL5+IgDnegB cells that…2020 American Transplant Congress
Treg Use PD-1 for Lymphatic Migration
*Purpose: Regulatory T cell (Treg) lymphatic migration is important for immune tolerance. Treg express both programmed death-1 (PD-1) and its ligand PD-L1, which are important…2020 American Transplant Congress
Chronic Kidney Disease Alters the T Cell Response to Murine Cytomegalovirus
*Purpose: We have previously reported that patients with chronic kidney disease (CKD) accumulate memory T cells bearing markers of sustained antigen stimulation and enhanced pro-inflammatory…2020 American Transplant Congress
Detrimental Effects of Donor Brain Death on Tolerance Induction May be Eliminated by Delaying Mixed Chimerism in Non-Human Primates
*Purpose: Induction of tolerance to heart allografts in non-human primates is possible with kidney cotransplantation and mixed chimerism-based induction therapy. However, donor brain death abrogates…2020 American Transplant Congress
Medical and Psychosocial Reasons for Deferral and Denial Following Kidney Transplant Evaluation at a VA Transplant Center
*Purpose: VA kidney transplant patients present challenges that may limit their listing opportunities in the private sector. We sought to study the medical and psychosocial…2020 American Transplant Congress
Two-Year Post-Transplant eGFR as a Surrogate Outcome of Allograft Survival in Kidney Transplant Recipients
*Purpose: Graft failure is a major cause of morbidity and mortality in kidney transplant recipients. However, trials aimed to assess the effect of interventions on…2020 American Transplant Congress
Treg Protection of the Allograft Depends on Lymphotoxin Beta Receptor Expression in Lymphatic Endothelial Cells
1University of Maryland, Baltimore, Baltimore, MD, 2Harvard U, Boston, MA
*Purpose: Regulatory T cell (Treg) migration to afferent lymphatics and lymph nodes (LN), and suppressive function, require Treg lymphotoxin alpha (LTα) to stimulate LT beta-receptor…
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