Am J Transplant, Volume 20, Suppl 3 Archives - Page 42 of 223 - ATC Abstracts

2020 American Transplant Congress
Erythropoietin Reduces Alloantibody Formation by Inhibiting T Follicular Helper Cells
C. Cantarelli¹, C. Guglielmo², S. Bin², A. Cumpelik², C. Donadei³, L. Anderson⁴, S. Hartzell², K. Budge², M. Haverly², A. Angeletti³, G. La Manna³, E. Fiaccadori¹, U. Maggiore¹, P. Heeger², P. Cravedi²
¹Parma University, Parma, Italy, ²Icahn School of Medicine at Mount Sinai, New York, NY, ³St. Orsola Hospital University of Bologna, Bologna, Italy, ⁴Icahn School of Medicine, New York, NY
*Purpose: Donor-specific antibodies (DSA) develop in a significant minority of transplant recipients and are associated with increased morbidity and mortality, underscoring the need to identify…
2020 American Transplant Congress
Novel Insights Into High Alloantibody Production in CCR5 KO Recipient Mice
J. L. Han¹, J. M. Zimmerer², Q. Zeng³, B. A. Ringwald¹, C. K. Breuer³, G. L. Bumgardner²
¹Ohio State University, Columbus, OH, ²Transplant Surgery, Ohio State University, Columbus, OH, ³Nationwide Children's Hospital, Columbus, OH
*Purpose: Antibody-mediated rejection (AMR) contributes to both early and late kidney allograft loss. Unfortunately, conventional immunosuppressants do not effectively control development of humoral alloimmunity in…
2020 American Transplant Congress
Dissecting Humoral Alloimmune Sensitization: A Dynamic Interplay of Different Cellular Compartments
A. Torija, A. Favà, E. Crespo, M. Jarque, M. Meneghini, N. Bolaños, J. Grinyo, O. Bestard
Kidney transplantation Unit, Bellvitge University Hospital- IDIBELL, L'Hospitalet de Llobregat. Barcelona, Spain
*Purpose: Humoral alloimmune memory is the main barrier for successful transplantation and is generated by a complex and compartmentalized B-cell immune response. Understanding the role…
2020 American Transplant Congress
Cmv Infection Sensitizes Transplant Recipients by Promoting Alloreactive T Cell Response
S. Yu, A. Dangi, X. Luo
Nephrology/Medicine, Duke University, Durham, NC
*Purpose: Cytomegalovirus (CMV) infection has been associated with allograft rejection in immunosuppressed transplant recipients. We have previously shown that acute CMV infection impairs the induction…
2020 American Transplant Congress
A Novel Polymer Product, APP-103, Reduces IRI-Induced Damage and Promotes Functional Improvement in Syngeneic Models of Renal Transplantation
K. Minami¹, S. Bae², H. Uehara¹, J. Iske¹, J. Reder³, H. Azuma⁴, A. Weins¹, E. Van Keuren⁵, B. Houser³, A. El-Khal¹, P. Kang², S. Tullius¹
¹Brigham and Women's Hospital, Boston, MA, ²Beth Israel Deaconess Medical Center, Boston, MA, ³Celdara Medical, Lebanon, NH, ⁴Osaka Medical College, Osaka, Japan, ⁵Georgetown University, Washington DC, DC
*Purpose: Our data introduce APP-103 as a novel, non-toxic and site-activating therapeutic approach that effectively ameliorates the consequences of ischemia/reperfusion injury in solid organ transplantation.*Methods:…
2020 American Transplant Congress
Hemodialysis (HD) Treatment Associates with Increased Risk of Delayed Graft Function (DGF) after Renal Transplantation (RT) and Augmented Cd4 and Cd8 T Cell Proliferation Compared to Peritoneal Dialysis (PD)
A. Angeletti¹, C. Donadei¹, G. Donati¹, G. Di Certo¹, D. Conte¹, L. Gasperoni¹, E. Pelizzaro¹, C. Guglielmo¹, G. Comai¹, P. Cravedi², G. La Manna¹
¹DIMES, S.Orsola-Malpighi Hospital, Bologna University, Bologna, Italy, ²DIMES, Icahn School of Medicine at Mount Sinai, New York, NY, US, New York, NY
*Purpose: Delayed graft function (DGF) is a common event after RT that increases the risk of acute rejection and early graft loss. The impact of…
2020 American Transplant Congress
Molecular Phenotypes of Liver Transplant Injury: The INTERLIVER Study
K. S. Madill-Thomsen¹, P. F. Halloran¹, &. the INTERLIVER Study Group²
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ²., ., AB, Canada
*Purpose: Liver parenchymal injury phenotypes are difficult to evaluate by histology but could be amenable to molecular assessment. Having developed a Molecular Microscope® Diagnostic System…
2020 American Transplant Congress
Racial Differences in Acceptance of Public Health Service (PHS) Increased Risk Kidneys and Hepatitis C (HCV) Nat Positive Kidneys
K. Atiemo, S. Giusti, A. Paramesh, M. Killackey, H. Jeon
Tulane University, New Orleans, LA
*Purpose: PHS increased risk kidneys and HCV NAT positive kidneys represent a significant proportion of the donor pool however, acceptance demands explicit patient consent that…
2020 American Transplant Congress
Variability in Educational Content about Kidney Paired Donation at 68 National Kidney Registry-Affiliated Centers
A. D. Waterman¹, O. N. Ranasinghe¹, E. H. Wood¹, J. L. Beaumont², S. McGuire³, K. Miller⁴, V. Chipman⁵, J. Sinacore⁶, M. Cooper⁷
¹Division of Nephrology, David Geffen School of Medicine, Los Angeles, CA, ²Terasaki Research Institute, Los Angeles, CA, ³UCLA Kidney and Pancreas Transplant Programs, Los Angeles, CA, ⁴UW Health, Madison, WI, ⁵UCSF Medical Center, San Francisco, CA, ⁶National Kidney Registry, Babylon, NY, ⁷Medstar Georgetown Transplant Institute, Washington, DC
*Purpose: Equipping patients and donors with in-depth information about kidney paired donation (KPD) processes, risks, benefits, and protections is necessary for informed decision-making and comfort.…
2020 American Transplant Congress
Introducing the Smartphone App, EL-FIT (Exercise & Liver FITness), to Help Monitor and Prehabilitate Liver Transplant Candidates
A. Duarte-Rojo¹, P. M. Bloomer¹, R. J. Rogers², M. A. Dunn¹, E. B. Tapper³, R. Bataller¹, C. B. Hughes¹, A. A. Ferrando¹, W. R. Kim⁴, J. M. Jakicic²
¹University of Pittsburgh Medical Center, Pittsburgh, PA, ²University of Pittsburgh, Pittsburgh, PA, ³University of Michigan, Ann Arbor, MI, ⁴Stanford University, Palo Alto, CA
*Purpose: Physical activity is key to liver transplant (LT) prehabilitation, and leveraging technologies to monitor physical performance and to generalize training may be advantageous. EL-FIT…