ATC Abstracts

American Transplant Congress abstracts

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  • 2020 American Transplant Congress

    Maintenance Belatacept Therapy is Associated with Increased Rates of Polyoma Viremia

    D. Conti, E. Maciera, D. Pluckrose, M. Garner, D. Schuster, S. Patel

    Albany Medical Center, Albany, NY

    *Purpose: The introduction of belatacept costimulatory blockade therapy has added a novel and powerful agent to the immunosuppressive armamentarium utilized after renal transplantation. However, limited…
  • 2020 American Transplant Congress

    Total Penis, Scrotum, and Lower Abdominal Wall Transplant: 18-Month Update

    D. S. Cooney1, C. M. Cooney1, V. Javia1, J. T. Shores1, A. L. Burnett2, T. J. Bivalacqua2, G. Brandacher1, R. J. Redett1

    1Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, 2Urology, Johns Hopkins University School of Medicine, Baltimore, MD

    *Purpose: In 2018 we performed a total penis, scrotum, and lower abdominal wall transplant on a man who had sustained a loss of his bilateral…
  • 2020 American Transplant Congress

    Hypothermic Machine Perfusion Can Improve Hypoxia Tolerance in Human Discarded Liver

    T. Ito, K. Kadono, H. Kojima, S. Kageyama, H. HIrao, K. Nakamura, K. J. Dery, A. E. Murray, J. Aziz, R. W. Busuttil, J. Kupiec-Weglinski, F. M. Kaldas

    The Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA

    *Purpose: The wider use of livers from expanded criteria donors may help improve access to liver transplantation (LT). Normothermic machine perfusion in LT has been…
  • 2020 American Transplant Congress

    Single Cell Gene Profiling Highlights Novel B Cell Populations Associated with the Development of Bronchiolitis Obliterates Syndrome after Lung Transplantation

    N. F. Smirnova1, K. Riemondy2, S. Collins1, J. Hesselberth2, O. Eickelberg1

    1Dept of Medicine - Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado - Anschutz Medical Campus, Aurora, CO, 2University of Colorado - Anschutz Medical Campus, Aurora, CO

    *Purpose: The occurence of bronchiolitis obliterans syndrome (BOS) accounts for a poor long term prognosis after lung transplantation (LTx). Despite immunosuppressive T cell-targeting therapies the…
  • 2020 American Transplant Congress

    Creation of a Low-Cost Kidney Transplant Surgery Simulator and Survey of its Utility for Education

    V. Melkonian, T. Huy, C. Varma, M. Nazzal, H. Randall, M. Nguyen

    Department of Surgery, Saint Louis University, Saint Louis, MO

    *Purpose: Surgical skills education in transplant surgery is challenging as center-specific outcomes are scrutinized and trainees’ exposure to the sub-specialty is decreasing. Simulation could overcome…
  • 2020 American Transplant Congress

    Anti-HLA IgM Antibodies are Unaffected by Imlifidase (IdeS) Treatment

    A. Runström1, R. Bockermann1, K. Sjöholm1, K. M. Roupé1, Å. Schiött1, L. Winstedt1, C. Kjellman1, T. Lorant2

    1Hansa Biopharma AB, Lund, Sweden, 2Section of Transplantation Surgery, Department of Surgical Sciences, Uppsala, Sweden

    *Purpose: The immunoglobulin G (IgG)-degrading cysteine protease, imlifidase (IdeS) is an IgG endopeptidase under development as a rapid desensitization treatment in kidney transplantation. Imlifidase is…
  • 2020 American Transplant Congress

    Domino Transplantation – Expanding the Liver Donor Pool to the Pediatric Recipient

    U. Ekong1, N. Yazigi1, K. Khan1, S. Kaufman1, K. Chapman2, E. Leon2, N. Ah Mew2, A. Kroemer1, R. Girlanda1, J. Hawksworth1, C. Matsumoto1, T. Fishbein1

    1MedStar Georgetown Transplant Institute, Washington, DC, 2Genetics, Children's National Hospital, Washington, DC

    *Purpose: Background: Maple syrup urine disease (MSUD) is an inherited autosomal recessive metabolic disorder of amino acid metabolism, caused by a defect of the branched-chain…
  • 2020 American Transplant Congress

    Impact of CYP3A5 Phenotype on Early Time in Therapeutic Range among Pediatric Renal and Heart Transplant Recipients

    A. Leino, A. Pasternak

    University of Michigan, Ann Arbor, MI

    *Purpose: Tacrolimus time in therapeutic range (TTR) as a measure of intra-patient variability has been associated with poor long-term outcomes. Multiple factors may contribute to…
  • 2020 American Transplant Congress

    Impact of Eplet Mismatches on the Risk of Graft Loss: Not All Eplets are Created Equal

    H. Mohammadhassanzadeh1, W. Klement2, H. Gebel3, B. Foster4, P. Keown5, K. Oualkacha6, R. Sapir-Pichhadze1

    1Medicine, McGill University, Montreal, QC, Canada, 2Organ Donation and Transplantation, Canadian Blood Services, Ottawa, ON, Canada, 3Emory University Hospital, Atlanta, GA, 4Montreal Children's Hospital, Montreal, QC, Canada, 5Medicine, University of British Columbia, Vancouver, BC, Canada, 6Université du Québec À Montréal, Montreal, QC, Canada

    *Purpose: To mitigate risks related to HLA incompatibility, we assessed whether some unique sequence defined HLA targets (eplets) are associated with graft failure while others…
  • 2020 American Transplant Congress

    The Inflammatory Response in the Context of Tissue Injury: Roles of Tyro3, Axl, and Mer (TAM) Receptors in Liver Ischemia/Reperfusion Injury

    J. Zhang, M. Ni, D. Jin, H. Zhang, R. Busuttil, J. Kupiec-Weglinski, Y. Zhai

    Dumont-UCLA Transplant Center, Los Angeles, CA

    *Purpose: Although the inflammatory response in liver ischemia reperfusion injury has been studied extensively, how the context of tissue injury (presence of necrotic/apoptotic cells) regulates…
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