Am J Transplant, Volume 20, Suppl 3 Archives - Page 35 of 223 - ATC Abstracts

2020 American Transplant Congress
Long-Term Outcomes with Islet Alone and Islet-after-Kidney Transplantation for Type 1 Diabetes in the Clinical Islet Transplantation Consortium
M. R. Rickels¹, T. L. Eggerman², L. Bayman³, J. C. Qidwai³, R. Alejandro⁴, N. D. Bridges⁵, B. J. Hering⁶, J. F. Markmann⁷, P. A. Senior⁸, L. G. Hunsicker³
¹Institute for Diabetes, Obesity & Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, ²National Institute of Diabetes and Digestive and Kidney Disease, Bethesda, MD, ³University of Iowa, Iowa City, IA, ⁴University of Miami, Miami, FL, ⁵National Institute of Allergy and Infectious Disease, Bethesda, MD, ⁶University of Minnesota, Minneapolis, MN, ⁷Massachusetts General Hospital, Boston, MA, ⁸University of Alberta, Edmonton, AB, Canada
*Purpose: Phase 3 studies of islet transplant alone (ITA; n=48) and islet-after-kidney (IAK; n=24) transplantation in type 1 diabetes complicated by severe hypoglycemic events (SHE)…
2020 American Transplant Congress
Orthogonal IL-2 Cytokine-Receptor Pair Capable of Selective Expansion of Regulatory T Cells Facilitates Alloengraftment
T. Hirai¹, F. Simonetta², L. L. Su³, L. Picton³, J. Baker², J. Lin⁴, P. Li⁴, W. J. Leonard⁴, K. C. Garcia³, R. S. Negrin²
¹Department of Urology, Tokyo Women's Medical University, Tokyo, Japan, ²Division of Blood and Marrow Transplantation, Stanford University, Stanford, CA, ³Departments of Molecular and Cellular Physiology and Structural Biology, Stanford University, Stanford, CA, ⁴Laboratory of Molecular Immunology, National Institutes of Health, Bethesda, MD
*Purpose: Adoptive transfer of regulatory T cells (Tregs) has been shown to improve alloengraftment in animal models. However, ex vivo Treg expansion for the purpose…
2020 American Transplant Congress
Frailty Prevalence among Younger and Older Kidney Transplant Candidates and Recipients
X. Chen¹, N. Chu¹, J. Walston², D. Segev¹, M. McAdams DeMarco¹
¹Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, ²Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD
*Purpose: Frailty is associated with decreased access to kidney transplantation and poor post kidney transplant (KT) outcomes. This paper aims to explore the prevalence and…
2020 American Transplant Congress
Can Predonation Ambulatory Blood Pressure Monitoring Predict Postdonation Renal Function?
M. Mohamed Ahmed, M. Posadas Salas, D. Taber, V. Rao, K. Soliman, M. Casey
Medical University of South Carolina, Charleston, SC
*Purpose: Data on living kidney donor outcomes are of topical interest to the transplant community. Despite thorough pre-donation screening and risk assessment, a minority of…
2020 American Transplant Congress
Liver Transplantation of Hepatitis C Viremic Donors to Hepatitis C Naive Recipients
R. K. Gilroy, F. Lopez-Verdugo, G. Harmston, S. Fujita, M. E. Boschert, I. Zendejas, E. J. Frech, A. Gagnon, R. Jones, J. Krong, S. Sell, S. Dow, L. Lindberg, M. Rodriguez-Davalos, D. Alonso
Transplant Services, Intermountain Healthcare, Murray, UT
*Purpose: This study describes outcomes, out to 3 years, at one of the first centers in the United States to begin Hepatitis C Virus (HCV)-Nucleic…
2020 American Transplant Congress
Influenza-Associated Hospitalizations in Pediatric Solid Organ Transplant Recipients
Z. Haddadin¹, V. Probst¹, H. Rahman¹, M. Hall², C. Thurm², N. Halasa¹, J. Godown³, D. E. Dulek¹
¹Pediatric Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN, ²Children's Hospital Association, Lenexa, KS, ³Pediatric Cardiology, Vanderbilt University Medical Center, Nashville, TN
*Purpose: Pediatric solid organ transplant (pSOT) recipients are at high risk for severe influenza virus infection. Data regarding the incidence, morbidity, mortality, and economic burden…
2020 American Transplant Congress
Activated Circulating Memory TFollicular Helper Cells with Self-Renewal Potential Underlie the Kidney Allograft Antibody-Mediated Rejection Response
K. Louis¹, C. Macedo¹, E. Bailly¹, B. Ramaswami¹, M. Marrari¹, T. Shi¹, D. Landsittel¹, U. Chandran¹, P. Fadakar¹, M. Yamada¹, G. Chalasani¹, P. Randhawa¹, A. Zeevi¹, C. Lefaucheur², D. Metes¹
¹Surgery, University of Pittsburgh, Pittsburgh, PA, ²Inserm UMR 976, Paris, France
*Purpose: Antibody-mediated rejection (ABMR) is the leading cause of allograft failure after organ transplantation. Yet, the cellular events that lead to the induction of a…
2020 American Transplant Congress
Preventing Allograft Rejection by Circrna FSCN1 Mediated Tolerogenic Dendritic Cells
B. Wang, Q. Zhou, V. Veramkovich, A. Greasley, S. Li, X. Zheng
Pathology, University of Western Ontario-LHSC, London, ON, Canada
*Purpose: Induction of immune tolerance is a major challenge in heart transplants. There is no robust treatment with fewer side effects for preventing chronic rejection.…
2020 American Transplant Congress
Characterization of Histological Phenotypes of Acute Rejection Episodes in Kidney Transplant Recipient Receiving a Single 3mg/kg Dose of Rabbit Antithymocyte Globulin
R. S. Campos¹, M. Cristelli¹, H. Proença², R. D. Foresto¹, L. Viana¹, S. Stopa Martins¹, M. Nakamura¹, L. Takara¹, J. Taddeo¹, C. Felipe¹, H. T. Tedesco Jr.¹, J. Pestana¹
¹Nephrology Division, Hospital Do Rim, Sao Paulo, Brazil, ²Pathology Division, Hospital Do Rim, Sao Paulo, Brazil
*Purpose: Late acute rejections appear to exert a more negative effect on graft kidney allograft survival than earlier events. Literature lacks studies that detail the…
2020 American Transplant Congress
Glomerulitis in One-Hour Biopsy after ABO-Blood Type Incompatible Kidney Transplantation Sensitively Suggests Occurrence of Antibody-Mediated Rejection
D. Iwami, K. Hotta, N. Iwahara, N. Shinohara
Renal and Genitourinary Surgery, Hokkaido University, Graduate School of Medicine, Sapporo, Japan
*Purpose: Antibody-mediated rejection (ABMR) after ABO-blood type-incompatible kidney transplantation (ABOi-KTx) can affect transplant outcome even lead to allograft loss unless promptly diagnosed and adequately treated.…