2020 American Transplant Congress
Single Cell Analysis Reveals Endothelial Activation of Interleukin-6 Mediated Signaling Pathway in Microvascular Inflammation with and without c4d
1University of Michigan, Ann Arbor, MI, 2Henry Ford Hospital, Detroit, MI
*Purpose: Microvascular inflammation (MVI) is a feature of antibody mediated rejection. MVI can be seen with or without activation of other effectors of antibody injury…2020 American Transplant Congress
Autologous Expanded Tregs Promote Bone Marrow Engraftment and Donor Kidney Survival in Non-Human Primate Chimerism Model
*Purpose: Mixed chimerism (MC) induced with non-myeloablative conditioning in monkeys and humans induces tolerance to 70% of kidney grafts transplanted at the time of BMT.…2020 American Transplant Congress
Recurrent Focal Segmental Glomerulosclerosis and the Possibility of Re-Transplantation
1Urology, UCLA, Los Angeles, CA, 2Nephrology, UCLA, Los Angeles, CA
*Purpose: Up to 30% of patients with focal segmental glomerulosclerosis (FSGS) experience recurrent disease after renal transplant, with high rates of progression to allograft failure…2020 American Transplant Congress
Higher State-Level Demand for Renal Transplantation is Associated with Lower Deceased Donor Kidney Transplantation Rate
University of Alabama at Birmingham Hospital, Birmingham, AL
*Purpose: Geographic disparities in deceased donor kidney transplantation (DDKT) persist despite increased allocation system oversight and complexity. The association between poor population health and fewer…2020 American Transplant Congress
Most Complications of Hand-Assisted Laparoscopic Living Donor Nephrectomy Occur after Initial Discharge Including Most Reoperations: A Single-Center Retrospective Study
Kidney Transplant, Mayo Clinic, Rochester, MN
*Purpose: While most studies of hand-assisted laparoscopic living donor nephrectomy (HALLDN) report complications until discharge, this study examined complications up to 120 days.*Methods: We assessed…2020 American Transplant Congress
Less Bleeding Associated with Apixaban versus Other Direct Acting Oral Anticoagulation in Solid Organ Transplant Recipients
*Purpose: Owing to their fixed dosing and favorable drug interaction profiles, direct acting oral anticoagulants (DOACs) have supplanted warfarin as the standard of care for…2020 American Transplant Congress
Re-Transplantation (Tx) in Pediatric Patients with Failure of Primary Transplant (Tx) Due to Recurrent Focal Segmental Glomerulosclerosis (FSGS). A Pediatric Nephrology Research Consortium (PNRC) Study
*Purpose: FSGS is a leading cause of end stage renal disease (ESRD). Tx in patients with FSGS may lead to graft failure due to recurrence…2020 American Transplant Congress
Multifaceted Roles of Follicular T Cell Subsets in Controlling Antibody Mediated Rejection
Renal- Transplant Research Center, Brigham and Women's Hospital- Harvard Medical School, Boston, MA
*Purpose: Assess the roles of T Follicular Helper and Regulatory cells in controlling pathogenic donor-specific antibodies (DSA) and antibody-mediated rejection(AbMR) during kidney transplantation.*Methods: Here we…2020 American Transplant Congress
Frailty and Its Implications for Early Post-Transplant Outcomes in Kidney Transplant Recipients
Toronto General Hospital, Toronto, ON, Canada
*Purpose: Frailty, a measure of physiologic reserve, is associated with poor early outcomes, like early hospital readmission (EHR) and delayed-graft function (DGF) in kidney transplant…2020 American Transplant Congress
Clinical Implications of Tacrolimus Time in Therapeutic Range in Urban Renal Transplant Recipients Under an Early Corticosteroid Withdrawal Protocol
University of Illinois at Chicago, Chicago, IL
*Purpose: Tacrolimus displays wide inter- and intra-patient variability, necessitating therapeutic drug monitoring. Assessing the duration of time in therapeutic range (TTR) is an additional tool…
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