Am J Transplant, Volume 20, Suppl 3 Archives - Page 35 of 223 - ATC Abstracts

2020 American Transplant Congress
A Call to Action: Finding the Right Kidney for All Potential Recipients
G. Guerra, L. Preczewski, A. Harshman, G. Ciancio, R. Vianna, J. Figueiro, M. Muldoon
Miami Transplant Institute, Miami, FL
*Purpose: The dialysis burden in patients with end stage renal disease (ESRD) awaiting a kidney transplant (KT) is a huge driver of morbidity, mortality, and…
2020 American Transplant Congress
Liver Transplant Waitlist Mortality is Not Associated with Urbanicity
Y. Chen¹, Y. Hung², Y. Hsu³, C. de Crescenzo¹, C. Rickert¹, J. Adler⁴, D. Chang¹, H. Yeh¹
¹Surgery, Massachusetts General Hospital, Boston, MA, ²Surgery, Sinai Hospital of Baltimore, Baltimore, MA, ³Harvard School of Public Health, Boston, MA, ⁴Surgery, Brigham and Women's Hospital, Boston, MA
*Purpose: Because of geographic disparity in transplant rates and organ usage, distance-based liver distribution has been proposed to replace Donor Service Area based distribution. However,…
2020 American Transplant Congress
Immuno-Modulation of Primed Xenogeneic T Cell Response by mTOR Blockade of T Cells and Porcine Endothelial Cells
S. Li, A. Kirk, H. Xu
Surgery, Duke University, Durham, NC
*Purpose: Porcine vascular endothelial cells (PECs) play a central role in xeno-recognition and costimulation. The objectives of this study were to characterize the immuno-phenotype of…
2020 American Transplant Congress
Eplet Mismatch Imputed from HLA Serotype-Level Data Can Improve Risk Stratification for Kidney Allograft Loss
A. Heinzel, R. Reindl-Schwaighofer, A. Kainz, K. Hu, R. Oberbauer
Department of Medicine III - Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria
*Purpose: HLA-Epitope mismatch improves risk stratification following kidney transplantation. Based on population data, high resolution HLA types required for epitope prediction can be imputed based…
2020 American Transplant Congress
Endoscopic Injection Therapy for Vesicoureteral Reflux after Kidney Transplantation
H. Higuchi, H. Sasaki, H. Harada, T. Tanabe
Urology and Kidney Transplant Surgery, Sapporo City General Hospital, Sapporo, Sapporo, Japan
*Purpose: Vesicoureteral reflux (VUR) in a kidney graft is a complication of post kidney transplantation (KT) causing recurrent upper urinary tract infection and consequent kidney…
2020 American Transplant Congress
Complement Activation and Delayed Graft Function after Kidney Transplantation
C. Arias-Cabrales¹, M. Pérez-Sáez¹, M. Riera¹, J. Gimeno², D. Benito¹, D. Redondo-Pachón¹, A. Buxeda¹, C. Burballa¹, M. Crespo¹, J. Pascual¹, E. Rodríguez¹
¹Nephrology, Hospital Del Mar, Barcelona, Spain, ²Pathology, Hospital Del Mar, Barcelona, Spain
*Purpose: Ischemia-reperfusion (I/R) damage is the most important cause of delayed graft function (DGF), which has a negative impact on kidney transplant (KT) outcomes. Complement…
2020 American Transplant Congress
dd-cfDNA as a Risk Factor for Initiating De-Novo Donor Specific Antibodies in Heart Transplantation
E. DePasquale¹, J. Kobashigawa², S. Pinney³, K. Khush⁴
¹Keck Hospital of USC, Los Angeles, CA, ²Cedars-Sinai, Beverly Hills, CA, ³Mount Sinai Health System, New York, NY, ⁴Stanford University, Stanford, CA
*Purpose: We hypothesize that subclinical inflammation, resulting in molecular injury of the cardiac allograft, may contribute to sensitization of the recipients’ immune system. Antigenic presentation…
2020 American Transplant Congress
Dominant Negative Polymorphisms in TNFRSF13B are Associated with Poor Transplant Outcome
M. G. de Mattos-Barbosa¹, E. T. Luning Prak², E. Farkash³, J. L. Platt⁴, M. Cascalho⁴
¹Transplant Surgery, University of Michigan, Ann Arbor, MI, ²Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, ³Pathology, University of Michigan, Ann Arbor, MI, ⁴Transplant Surgery and Microbiology and Immunology, University of Michigan, Ann Arbor, MI
*Purpose: Transmembrane Activator and CAML Interactor (TACI) is a highly polymorphic receptor that controls B cell activation and differentiation into antibody-secreting cells. Allelic variants of…
2020 American Transplant Congress
Cardiac Transplantation is Accompanied by Major T and NK Cell Alterations within the First 24 Hours
J. Iske¹, B. Wiegmann², K. Ludwig¹, N. Ledwoch¹, E. Chichelnitskiy¹, J. F. Kühne¹, A. Hitz¹, R. Bellmàs-Sanz¹, K. Daemen¹, J. Keil¹, F. Ius², S. Rochas², A. Knoefel², A. Haverich², G. Warnecke², C. S. Falk¹
¹Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany, ²Division of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany
*Purpose: Allogeneic heart transplantation (HTx) displays the only curative approach for terminal heart insufficiency while acute allograft rejection remains a major complication. However, early kinetics…
2020 American Transplant Congress
Effects of Subnormothermic Ex Vivo Lung Perfusion on Inflammatory Injury in a Murine Lung Transplant Model
J. N. Gloria¹, S. J. Kesseli², J. Yerxa², M. Zhang², M. Zhu², W. Parker², R. P. Davis², A. S. Barbas², M. G. Hartwig³
¹Duke University School of Medicine, Durham, NC, ²Department of Surgery, Duke University Medical Center, Durham, NC, ³Department of Thoracic Surgery, Duke University Medical Center, Durham, NC
*Purpose: Ex vivo lung perfusion (EVLP) has emerged as a technique that safely preserve lungs prior to transplantation. Recent evidence demonstrates increased levels of inflammatory…