Am J Transplant, Volume 20, Suppl 3 Archives - Page 32 of 223 - ATC Abstracts

2020 American Transplant Congress
Dominant Negative Polymorphisms in TNFRSF13B are Associated with Poor Transplant Outcome
M. G. de Mattos-Barbosa¹, E. T. Luning Prak², E. Farkash³, J. L. Platt⁴, M. Cascalho⁴
¹Transplant Surgery, University of Michigan, Ann Arbor, MI, ²Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, ³Pathology, University of Michigan, Ann Arbor, MI, ⁴Transplant Surgery and Microbiology and Immunology, University of Michigan, Ann Arbor, MI
*Purpose: Transmembrane Activator and CAML Interactor (TACI) is a highly polymorphic receptor that controls B cell activation and differentiation into antibody-secreting cells. Allelic variants of…
2020 American Transplant Congress
Cardiac Transplantation is Accompanied by Major T and NK Cell Alterations within the First 24 Hours
J. Iske¹, B. Wiegmann², K. Ludwig¹, N. Ledwoch¹, E. Chichelnitskiy¹, J. F. Kühne¹, A. Hitz¹, R. Bellmàs-Sanz¹, K. Daemen¹, J. Keil¹, F. Ius², S. Rochas², A. Knoefel², A. Haverich², G. Warnecke², C. S. Falk¹
¹Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany, ²Division of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany
*Purpose: Allogeneic heart transplantation (HTx) displays the only curative approach for terminal heart insufficiency while acute allograft rejection remains a major complication. However, early kinetics…
2020 American Transplant Congress
Effects of Subnormothermic Ex Vivo Lung Perfusion on Inflammatory Injury in a Murine Lung Transplant Model
J. N. Gloria¹, S. J. Kesseli², J. Yerxa², M. Zhang², M. Zhu², W. Parker², R. P. Davis², A. S. Barbas², M. G. Hartwig³
¹Duke University School of Medicine, Durham, NC, ²Department of Surgery, Duke University Medical Center, Durham, NC, ³Department of Thoracic Surgery, Duke University Medical Center, Durham, NC
*Purpose: Ex vivo lung perfusion (EVLP) has emerged as a technique that safely preserve lungs prior to transplantation. Recent evidence demonstrates increased levels of inflammatory…
2020 American Transplant Congress
Establishing an Induction Protocol for Long-Term Multilineage Mixed Chimerism in Rhesus Macaques
K. Bruestle¹, H. Sakai¹, F. Fredriksson¹, B. Piegari¹, D. Ekanayake-Alper¹, A. McLuckie², R. Ober², J. Weiner¹, A. Iuga³, S. M. Coley³, M. Sykes¹, A. Griesemer¹
¹Columbia Center for Translational Immunology, Columbia University, New York City, NY, ²Institute for Comparative Medicine, Columbia University, New York City, NY, ³Department of Pathology and Cell Biology, Columbia University, New York City, NY
*Purpose: Mixed chimerism (MC) induction via non-myeloablative conditioning and bone marrow transplantation (BMT) induces tolerance to solid organs. Our standard MC induction protocol in cynomologous…
2020 American Transplant Congress
Comparison of 1-Year Incidence of De Novo Donor Specific Antibodies between Thymoglobulin and Alemtuzumab Induction in Kidney Transplantation
J. P. Knorr, C. Kallis, D. A. Portley, A. Jeyarajasingam, P. W. Lai, G. Bradauskaite, K. Khanmoradi
Transplant Nephrology, Einstein Medical Center, Philadelphia, PA
*Purpose: Development of de novo donor specific antibodies (dnDSA) after kidney transplantation (KTx) has been associated with acute and chronic antibody-mediated rejection, transplant glomerulopathy and…
2020 American Transplant Congress
Machine Learning to Predict Deceased Donor Kidney Biopsy Results
C. Martinez, A. Placona
United Network for Organ Sharing, Richmond, VA
*Purpose: Despite inconclusive evidence that kidney biopsy findings are associated with graft outcomes, biopsies are often cited as a key factor on whether to accept…
2020 American Transplant Congress
Do Higher Remuzzi Scores Make Good Kidneys Bad? Examining Histologic Criteria within the Framework of Single Kidney Transplantation
V. Fleetwood¹, C. Kensinger², C. Papageorge¹, D. Aufhauser¹, P. Pasha¹, G. Leverson³, B. Welch¹, D. Foley¹
¹Department of Transplantation, University of Wisconsin, Madison, WI, ²Department of Transplantation, Piedmont Transplant Center, Atlanta, GA, ³Department of Statistics, University of Wisconsin, Madison, WI
*Purpose: The Remuzzi score (RS), a histologic tool to assess chronic allograft damage, can guide allocation to single (SKT) or dual (DKT) kidney implantation. RS…
2020 American Transplant Congress
Standardization of Pre-Transplant Cardiac Testing in Kidney Transplant Recipients is Associated with Lower Post-Transplant Cardiac Events
I. Genev¹, A. Desai², R. Garcia-Roca³, S. Shah⁴, J. Lopez⁴, V. Mathew⁴, J. Yoo¹, S. Akkina¹
¹Department of Medicine, Loyola University Medical Center, Maywood, IL, ²Department of Medicine, Division of Transplant Nephrology, Loyola University Medical Center, Maywood, IL, ³Department of Surgery, Loyola University Medical Center, Maywood, IL, ⁴Department of Medicine, Division of Cardiology, Loyola University Medical Center, Maywood, IL
*Purpose: Cardiovascular disease is the leading cause of mortality after kidney transplantation and optimal approaches to pre-transplant cardiac testing are not well defined. We applied…
2020 American Transplant Congress
Treatment of Chronic Active Antibody Mediated Rejection in Kidney Transplant Recipients is Associated with Increased Risk of Urinary Tract Infections and Pneumonia
E. Joachim, S. Parajuli, K. Swanson, F. Aziz, N. Garg, M. Mohamed, D. Mandelbrot, A. Djamali
University of Wisconsin, Madison, WI
*Purpose: Infections are a common cause of morbidity and mortality after kidney transplantation. Chronic active antibody mediated rejection (cABMR) is a leading cause of kidney…
2020 American Transplant Congress
Multi- National Survey among Nephrologists & Transplant Surgeons about the Suitability and Acceptance of the Marginal Live Kidney Donors with Mild Hypertension
Z. Arabi¹, E. Elhassan¹, A. Altheaby¹, A. Hamad², S. Kaysi³
¹KAMC, Riyadh, Saudi Arabia, ²The Regional Medical Center, Orangeburg, SC, ³CHR Orleans, Orleans, France
*Purpose: There is variability among transplant centers in the acceptance of living donor candidates with well-controlled hypertension. Increased gestational hypertension and preeclampsia are more common…