Am J Transplant, Volume 20, Suppl 3 Archives - Page 216 of 223 - ATC Abstracts

2020 American Transplant Congress
Unsupervised Analysis of the Alloimmune Response Using Single-Cell Mass Cytometry
J. Harden, X. Wang, C. Esquivel, O. Martinez, S. Krams
Department of Surgery/Division of Abdominal Transplantation, Stanford Univ School of Med, Stanford, CA
*Purpose: Alloimmune responses in acute rejection are complex, involving multiple interacting cell types. Flow cytometry with biased pairwise gating is the gold standard to phenotype…
2020 American Transplant Congress
Using an Ex Vivo Blood-Free Model of Preservation and Reperfusion to Evaluate the Effects of Subnormothermic Perfusion with Hydrogen Sulfide on DCD Porcine Renal Grafts
S. Juriasingani¹, A. Ruthirakanthan¹, M. Richard-Mohamed², M. Zhang¹, M. Levine¹, E. Sogutdelen¹, M. Mandurah¹, A. Sener¹
¹University of Western Ontario, London, ON, Canada, ²London Health Sciences Centre, London, ON, Canada
*Purpose: The need for donor blood complicates the clinical translation of normothermic and subnormothermic perfusion for preservation and graft function evaluation. As such, hemoglobin-based oxygen…
2020 American Transplant Congress
The Requirement of Thymic Irradiation for Induction of Mixed Chimerism and Renal Allograft Tolerance in Non-Human Primates
T. Hirose¹, H. Sasaki¹, T. Oura¹, D. Ma¹, A. Dehnadi¹, R. B. Colvin², I. Rosales², A. B. Cosimi¹, T. Kawai¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Pathology, Massachusetts General Hospital, Boston, MA
*Purpose: Thymic irradiation (TI) has been required for consistent induction of allograft tolerance through a mixed chimerism approach in both murine and nonhuman primate (NHP)…
2020 American Transplant Congress
Donor-Derived Cell-Free DNA (dd-cfDNA) Levels in Stable Pediatric Kidney Transplant Recipients
M. Waide, J. Carmody, I. G. Restaino
Pediatrics, Eastern Virginia Medical School, Norfolk, VA
*Purpose: Among adult kidney transplant recipients, donor-derived cell-free DNA (dd-cfDNA) has been validated as a highly sensitive biomarker for graft rejection. Unfortunately, few data are…
2020 American Transplant Congress
KDPI-Based Kidney Discard Risk Assessment
S. Mehrotra¹, M. Barah², K. Bui³
¹IEMS Department, MEAS, Northwestern University, Evanston, IL, ²IEMS Department, Northwestern University, Evanston, IL, ³Department of Mathematics, University of California, Irvine, Irvine, CA
*Purpose: Despite the vital need, 3,553 (19%) deceased-donor kidneys were discarded in 2018 in the current US allocation system. The discard rate has remained at…
2020 American Transplant Congress
Impact of Severity of Glomerulosclerosis on Long-Term Outcomes in Deceased Donor Renal Transplant Recipients with Donor Acute Kidney Injury
A. Brar¹, A. Gruessner², D. Adey¹, M. Salifu²
¹University of California, San Francisco, San Francisco, CA, ²SUNY Downstate Medical Center, Brooklyn, NY
*Purpose: With long waitlist times for renal transplantation,there is a need to reduce discard rates of donor kidneys.The purpose of this study is to assess…
2020 American Transplant Congress
Incidence, Clinical Correlates and Outcomes of Pulmonary Hypertension after Kidney Transplantation: Analysis of Linked U.S. Registry and Medicare Billing Claims
K. Lentine¹, S. Costa², Y. Caliskan³, D. Levine⁴, J. Runo⁵, H. Te⁶, J. Rangaswami⁷, D. Dadhania⁸, D. Axelrod⁹, M. Schnitzler³, H. Xiao¹, B. Kasiske¹⁰, J. Snyder¹⁰, T. Villines¹¹
¹Department of Medicine, Saint Louis Univ, Saint Louis, MO, ²Dartmouth, Lebanon, NH, ³Saint Louis Univ, Saint Louis, MO, ⁴UT Health, San Antonio, TX, ⁵Univ of Wisconsin, Madison, WI, ⁶Univ of Chicago, Chicago, IL, ⁷Einstein Medical Ctr, Philadelphia, PA, ⁸Weill Cornell, New York, NY, ⁹Univ of Iowa, Iowa City, IA, ¹⁰SRTR, Minneapolis, MN, ¹¹Univ of Virginia, Charlottesville, VA
*Purpose: To describe the incidence and mortality implications of pulmonary hypertension (P-HTN) in a large, national cohort of US kidney transplant (KTx) recipients.*Methods: We examined…
2020 American Transplant Congress
The Evolution and Impact of ABMR Histology and Transplant Glomerulopathy in the Presence or Absence of HLA-DSA
M. Coemans¹, A. Senev¹, G. Verbeke², M. Emonds¹, M. Naesens¹
¹Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, ²Leuven Biostatistics and Statistical Bioinformatics Centre (L-BioStat), KU Leuven, Leuven, Belgium
*Purpose: After kidney transplantation, the occurrence of ABMRh (=histological picture of antibody-mediated rejection) and transplant glomerulopathy (cg) has been reported, both in the presence and…
2020 American Transplant Congress
Multi-National Survey among Nephrologists and Transplant Surgeons About the Suitability and Acceptance of the Marginal Live Kidney Donors Regarding Age Discrepancy
Z. Arabi¹, S. Kaysi², A. Hamad³, M. Bukhari⁴, A. Mateen¹, E. Elhassan¹, A. Altheaby¹
¹KAMC, Riyadh, Saudi Arabia, ²CHR Orleans, Orleans, France, ³The Regional Medical Center, Orangeburg, SC, ⁴Taif University, Taif, Saudi Arabia
*Purpose: Living donor kidney transplantation is the best option for patients on dialysis. There are no guidelines or generally accepted consensus about the acceptable kidney…
2020 American Transplant Congress
Frailty Predicts Increased Length of Stay after Kidney Transplantation: An Implementation Study
J. Schaenman, B. Hale-Durbin, C. Lee, N. Ventigan, S. Jaladanki, L. Shih, B. Abdalla, R. Ahn, S. Chang, M. Dunbar-Forrest, H. A. Gritsch, G. Danovitch, D. Goldwater
David Geffen School of Medicine at UCLA, Los Angeles, CA
*Purpose: Our objective was to implement a standardized an assessment of physical frailty and other aging-associated syndromes during routine evaluation of kidney transplant candidates over…