2020 American Transplant Congress
Renal Immunoproteasome Function: A Possible Cause for Macrophage Associated Organ Damage During Renal Transplantation?
University of Arkansas for Medical Sciences, Little Rock, AR
*Purpose: A major hurdle in the field of renal transplantation is the shortage of suitable donor kidneys. Renal transplantation using living-donor organs perform better when…2020 American Transplant Congress
ANG-3777, A Hepatic Growth Factor Mimetic, Attenuates Mercuric Chloride-Induced Renal Dysfunction and Mortality in Rats
Angion Biomedica, Uniondale, NY
*Purpose: ANG-3777 is a small-molecule mimetic of hepatocyte growth factor (HGF). In vitro models have shown ANG-3777 to have protective effects in renal cell lines,…2020 American Transplant Congress
Ex Vivo Generated Regulatory B Cells Can Suppress Donor-Specific CD4 T Cells Proliferation In Vivo
*Purpose: B cells expanded in vitro via TLR9 agonist CpG and activated by LPS, PMA and ionomycin have been previously denoted “TLR-Bregs” by our team.…2020 American Transplant Congress
Characterization of CpG-stimulated, Tlr Regulatory, and Expanded Regulatory B Cells by RNA-Seq
Center for Transplant Science, MGH, Boston, MA
*Purpose: Our group previously reported three different types of in vitro generated B cell populations. Expanded regulatory B cells (eBregs), TLR regulatory B cells (TLR-Bregs),…2020 American Transplant Congress
Activation of Tacrolimus Induced Cytotoxicity Through Apoptotic Pathways
Department of Surgery, Chonnam National University, Gwangju, Korea, Republic of
*Purpose: To elucidate the mechanism of cytotoxicity in FK506-treated Jurkat T cells, signal transduction pathway of TNF-related events was studied.*Methods: Viability of Jurkat T cells…2020 American Transplant Congress
Decreased Anti-Tumor Activity of Liver-Resident NK Cells via IL-33 Associated with Portal Hypertension after Living Donor Liver Transplantation
Hiroshima Uni., Hiroshima, Japan
*Purpose: It has been reported that increasing portal vein pressure after living donor liver transplantation (LDLT) was associated with a poor prognosis, risk factors for…2020 American Transplant Congress
Development and Characterization of Decellularized Whole Human Livers for Increasing Donor Pool
Massachusetts General Hospital - Harvard Medical School, Boston, MA
*Purpose: Liver diseases are recognized as the second leading cause of mortality amongst all digestive diseases in the United States. Orthotopic liver transplantation leads to…2020 American Transplant Congress
Outcomes of Kidney Transplant Recipients with Depression and Anxiety
University of Minnesota, Minneapolis, MN
*Purpose: The outcomes of kidney transplantation in patients with depression and anxiety have been limited by small numbers. This is despite high prevalence of these…2020 American Transplant Congress
Older Organs Transfer Senescence to Transplant Recipients
1Brigham and Women's Hospital, Boston, MA, 2Mayo Clinic, Rochester, MN
*Purpose: Older organs represent an underutilized potential. Organ age, at the same time, augments alloimmune responses resulting into increased acute rejection rates. Senescent cells accumulate…2020 American Transplant Congress
Clinically Adjudicated Deceased Donor AKI and Graft Outcomes
*Purpose: We previously reported that AKI in deceased donors isn't associated with graft failure. As deceased donors undergo significant hemodynamic changes, we hypothesized that reversible…
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