Am J Transplant, Volume 20, Suppl 3 Archives - Page 209 of 223 - ATC Abstracts

2020 American Transplant Congress
The Impact of Epitope Mismatch Load and Shared Targeting Epitopes between De Novo Donor Specific Antibody (DSA) and Non-DSA Third Party HLA Antibody on Lung Transplantation Outcomes
A. Zhang¹, D. Good¹, D. Thomas¹, J. Allen¹, K. McCurry², M. Budev²
¹Allogen Laboratories, Cleveland Clinic, Cleveland, OH, ²Cleveland Clinic, Cleveland, OH
*Purpose: Rapid advancements in HLA typing and antibody identification technologies allow for enhanced HLA compatibility assessment at the epitope level to aid in the reduction…
2020 American Transplant Congress
Molecular Features of HLA Mismatches as Predictors of De Novo DSA Development: A Single Center Experience
V. Jucaud¹, L. Rebellato², K. Briley², C. Haisch², S. Kendrick³, H. Jones³, K. Mclawhorn³, D. Leeser², M. Everly¹
¹Terasaki Research Institute, Los Angeles, CA, ²East Carolina University, Greenville, NC, ³Eastern Nephrology Associates, Greenville, NC
*Purpose: Several molecular features (MoFs) of HLA mismatches (MMs) are currently used to predict the development of de novo donor-specific anti-HLA antibodies (dnDSA). The purpose…
2020 American Transplant Congress
Easier Said Than Done? Stated versus Actual Usage of Less-Than-Ideal Kidneys
D. Stewart, H. McGehee, J. Rosendale, D. Klassen
United Network for Organ Sharing, Richmond, VA
*Purpose: Despite long candidate waiting times and a persistent supply to demand gap, less-than-ideal (LTI) kidneys continue to be underutilized in the U.S. Usage rates…
2020 American Transplant Congress
Optimal Perioperative Management of Patients Undergoing Living Donor Nephrectomy Reduces Postoperative Length of Stay and Nausea and Vomiting
R. Chadha¹, S. Aniskevich¹, D. Perry², C. Taner², J. Burns²
¹Anesthesiology and Perioperative Medicine, Mayo Clinic Florida, Jacksonville, FL, ²Transplant Surgery, Mayo Clinic Florida, Jacksonville, FL
*Purpose: Renal transplantation with organs from living donors saves thousands of lives every year. In the perioperative period, poorly controlled nausea and pain can prolong…
2020 American Transplant Congress
The Addition of Splenectomy to Simultaneous Liver Kidney Transplantation Improves Class II DSA Clearance in Sensitized Patients
V. Fleetwood, D. Aufhauser, C. Papageorge, K. Janek, L. Hidalgo, B. Welch, R. Redfield, J. Mezrich
Department of Transplantation, University of Wisconsin, Madison, WI
*Purpose: The liver allograft clears class I donor specific antibody (DSA) more effectively than class II DSA. Persistent class II DSA in simultaneous liver kidney…
2020 American Transplant Congress
Testing Deceased Organ Donors for Infections: An Organ Procurement Organization (OPO) Survey
N. M. Theodoropoulos¹, P. Chin-Hong², M. Greenwald³, M. G. Ison⁴
¹University of Massachusetts Medical School, Worcester, MA, ²UCSF, San Francisco, CA, ³Uniformed Services University School of Medicine, Bethesda, MD, ⁴Northwestern University, Chicago, IL
*Purpose: We surveyed the 58 U.S. OPOs to update our knowledge about the current methods of infectious disease testing in deceased organ donors.*Methods: An IRB…
2020 American Transplant Congress
Evaluation of the Discrimination of 13 Mortality Risk Scores after Heart Transplantation in a Contemporary UNOS Cohort
G. Coutance, J. Patel, E. Kransdorf, R. Levine, E. Passano, J. Kobashigawa
Cedars-Sinai Smidt Heart Institute, Los Angeles, CA
*Purpose: Multiple pre-transplant scores aimed at stratifying the risk of death or allograft loss after heart transplantation have been developed over time but their use…
2020 American Transplant Congress
Survival of ESRD Patients with an EPTS > 90% Listed for Kidney Transplant
M. S. Sampaio¹, E. Lum¹, P. Homkrailas¹, G. Danovitch¹, H. Gritsch², S. Bunnapradist¹
¹UCLA - Division of Nephrology, Los Angeles, CA, ²UCLA - Division of Urology, Los Angeles, CA
*Purpose: Mortality on the kidney transplant waitlist is high especially in candidates with a high Estimated Post Transplant Survival (EPTS) score. We examined outcomes of…
2020 American Transplant Congress
Gene Expression Dynamics Demonstrate Perturbations in Innate and Adaptive Immunity in Kidney Transplantation Patients with Cytomegalovirus Viremia
R. Ahn, J. Schaenman, Z. Qian, V. Groysberg, M. Rossetti, A. Hoffmann, D. Gjertson, M. Deng, E. F. Reed
University of California Los Angeles, Los Angeles, CA
*Purpose: Cytomegalovirus (CMV) viremia and disease continues to cause significant morbidity and mortality in kidney transplant patients with clinical complications including organ rejection and death.…
2020 American Transplant Congress
The Impact of a Positive Crossmatch on KAS Patients and Organs
J. Lee¹, K. Sjöholm², C. Kjellman², T. Lorant², L. Winstedt², V. Nigro², K. M. Roupé², Å. Schiött², A. Runstrom², S. Taranto³, T. Baker³, D. Stewart³
¹Medical Affairs, Hansa Biopharma, Camas, WA, ²Hansa Biopharma, Lund, Sweden, ³UNOS, Richmond, VA
*Purpose: Evaluate the potential effects of offer refusals due to positive crossmatch (+XM) on both patients and re-allocated organs with a focus on waitlist outcomes,…