Am J Transplant, Volume 20, Suppl 3 Archives - Page 200 of 223 - ATC Abstracts

2020 American Transplant Congress
Effect of DSA-Free Heart Allocation
V. Patel¹, M. Skeans², T. Cascino¹, R. Davies³, M. Colvin¹
¹University of Michigan, Ann Arbor, MI, ²SRTR, Minneapolis, MN, ³UT Southwestern, Dallas, TX
*Purpose: Currently, donation service area (DSA) is the first geographic unit for heart allocation, which creates discrepancies in access for high-urgency candidates. We studied the…
2020 American Transplant Congress
Successful Tacrolimus Withdrawal in Kidney Transplant Recipients Unleashes a Peripheral Blood Transcriptional and Functional Signature Resembling Exhaustion
P. Cravedi, M. Fribourg, S. Harztell, L. Anderson, P. Heeger
Icahn School of Medicine at Mount Sinai, New York, NY
*Purpose: Tacrolimus (Tac) is an effective anti-rejection drug in kidney transplant recipients (KTR), but its off-target effects make withdrawal desirable. Studies indicate that Tac can…
2020 American Transplant Congress
Age-Enhanced Transplant Vasculopathy Associates with Impaired Vascular Mitophagy
M. Blin¹, D. Tyrrell¹, S. Wood¹, D. Farris¹, S. G. Tullius², D. R. Goldstein¹
¹Micro and Immunology/Internal Medicine, University of Michigan, Ann Arbor, MI, ²Transplant Surgery, Brigham and Women's Hospital, Boston, MA
*Purpose: Donor aging leads to increased chronic allograft vasculopathy (CAV) for unclear reasons. Here, we investigated whether impaired alterations in mitophagy, a mechanism to remove…
2020 American Transplant Congress
Significant Improvement in Short and Long-Term Kidney Transplant Survival Despite Stagnant Rates of Delayed Graft Function
J. Schold¹, S. Arrigain², E. Poggio³
¹Cleveland Clinic Foundation, Cleveland, OH, ²Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, OH, ³Nephrology, Cleveland Clinic Foundation, Cleveland, OH
*Purpose: Delayed Graft Function (DGF) is routinely characterized as attributing to significant morbidity and mortality among kidney transplant recipients. While there are diverse potential mechanisms…
2020 American Transplant Congress
Continuous Improvement in Long Term Survival of Kidney Transplants Over the Past Two Decades
E. D. Poggio¹, S. Arrigain², A. Wee³, D. C. Brennan⁴, J. D. Schold²
¹Nephrology, Cleveland Clinic, Cleveland, OH, ²Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, ³Urology, Cleveland Clinic, Cleveland, OH, ⁴Nephrology, Johns Hopkins, Baltimore, MD
*Purpose: Short-term kidney transplant (KTx) graft survival has improved during past decades, but prior research has indicated stagnation or minimally improving long-term outcomes. We studied…
2020 American Transplant Congress
The Impact of Non-Directed Anonymous Live Liver Donors on the Number of Children on the Waitlist at a Single Pediatric Liver Transplant Center
D. Yoeli¹, M. A. Adams¹, M. E. Wachs¹, S. S. Sundaram², R. A. Choudhury¹, K. D. Conzen¹, J. R. Burton³, E. A. Pomfret¹, W. E. Jackson³
¹Transplant Surgery, University of Colorado, Aurora, CO, ²Pediatric Hepatology, University of Colorado, Aurora, CO, ³Transplant Hepatology, University of Colorado, Aurora, CO
*Purpose: Since the initiation of our living donor (LD) pediatric liver transplant program in November 2016, 10 non-directed anonymous donors have been approved and completed…
2020 American Transplant Congress
Letermovir Treatment for Established Cytomegalovirus Infection in Transplant Recipients
K. Linder¹, C. Kovacs², K. Mullane³, C. Wolfe⁴, N. Clark⁵, C. Butkus Small⁶, R. La Hoz⁷, J. Smith⁸, C. Kotton⁹, A. Limaye¹⁰, M. Malinis¹¹, M. Hakki¹², A. Mishkin¹³, A. Gonzalez¹⁴, D. Kaul¹
¹U Michigan, Ann Arbor, MI, ²Cleveland Clinic, Cleveland, OH, ³U Chicago, Chicago, IL, ⁴Duke, Durham, NC, ⁵Loyola, Chicago, IL, ⁶Cornell, NYC, NY, ⁷UTSW, Dallas, TX, ⁸U Wisconsin, Madison, WI, ⁹Mass General, Boston, MA, ¹⁰U Washington, Seattle, WA, ¹¹Yale, New Haven, CT, ¹²OHSU, Portland, OR, ¹³Temple, Philadelphia, PA, ¹⁴West Coast ID, Safety Harbor, FL
*Purpose: The purpose of the study was to describe the patterns of use and clinical/virologic outcomes of letermovir treatment for established CMV infection in transplant…
2020 American Transplant Congress
Outcomes of Simultaneous Pancreas-Kidney vs. Kidney Alone Transplants in Type 2 Diabetic Recipients: A Multivariate Analysis of U.S. Transplants
S. M. Riad¹, S. Jackson², D. Keys¹, V. Humphereville³, L. Caramori¹, R. Kandaswamy³
¹Medicine, University of Minnesota, Minneapolis, MN, ²Complex Care Analytics, Fairview Health Services, Minneapolis, MN, ³Surgery, University of Minnesota, Minneapolis, MN
*Purpose: The impact of simultaneous pancreas-kidney (SPK) transplants in uremic, non-obese, insulin-treated type 2 diabetic (T2DM) recipients is not well described. We analyzed the SRTR…
2020 American Transplant Congress
Evaluation of Pre-Transplant T Cell Exhaustion as a Mechanism for Immune Dysfunction and Recipient Risk of Death Following Liver Transplant
K. E. Lunsford¹, N. Aware², K. Cleveland³, D. T. Nguyen⁴, E. A. Graviss⁴, L. J. Minze³, T. N. Eagar⁴, X. C. Li³, R. M. Ghobrial³
¹Department of Surgery, Rutgers New Jersey Medical School, Newark, NJ, ²Department of Surgery, Houston Methodist Hosptial, Houston, TX, ³Department of Surgery, Houston Methodist Hospital, Houston, TX, ⁴Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX
*Purpose: Cirrhosis-related immune dysfunction likely contributes to early mortality following liver transplant (LT) resulting from infections. We previously identified a pre-transplant biomarker panel for immune…
2020 American Transplant Congress
The Mechanism How the Transplanted Islets Engraft Into White Adipose Tissue
N. Sakata, G. Yoshimatsu, T. Tanaka, R. Kawakami, S. Kodama
Department of Regenerative Medicine and Transplantation, Fukuoka University, Fukuoka, Japan
*Purpose: While islet transplantation is recognized as a promising therapeutic option for severe diabetes mellitus (DM), especially type 1 DM, it still faces to various…