Am J Transplant, Volume 20, Suppl 3 Archives - Page 2 of 223 - ATC Abstracts

2020 American Transplant Congress
Human Thrombomodulin Gene Expression on Genetically Modified Donor Pig Hearts is Correlated with Long Term Xenograft Survival
A. K. Singh, C. Goerlich, G. Braileanu, A. Hersfield, T. Zhang, I. Tatarov, B. Lewis, F. Sentz, D. Ayares, K. Horvath, D. Kaczorowski, B. Griffith, M. M. Mohiuddin
Department of Surgery, University of Maryland Baltimore, Baltimore, MD
*Purpose: Thrombomodulin (TBM) is a coagulation regulatory protein which has shown a protective role against coagulation dysregulation and prevented thrombotic microangiopathy and premature loss of…
2020 American Transplant Congress
A New Diagnostic Approach to HLA Testing in Kidney Transplant Patients Using Renal Epithelial Cells
M. Herrmann¹, C. Bach², K. X. Knaup¹, M. Schiffer¹, B. Spriewald², M. S. Wiesener¹
¹Nephrology and Hypertension, University Hospital Erlangen, Erlangen, Germany, ²Haematology and Oncology, University Hospital Erlangen, Erlangen, Germany
*Purpose: In this study we present a new diagnostic approach to HLA typing in kidney transplant recipients using cultured renal tubular cells from urine samples…
2020 American Transplant Congress
Does the Choice of Renal Arterial Anastomotic Methods in Kidney Allografts with Multiple Renal Arteries Affect the Recovery Rate of Renal Plasma Flow after Kidney Transplantation?
K. Nishikawa, K. Shinoda, T. Yonekura, M. Maeda, H. Oguchi, Y. Hidaka, M. Muramatsu, T. Kawamura, Y. Hamasaki, K. Sakai, S. Shishido
Nephrology, Toho University, Faculty of Medicine, Ota-ku,Tokyo, Japan
*Purpose: In cases of kidney allografts with multiple renal arteries, renal arterial anastomotic methods vary in each recipient. The aim of this study is to…
2020 American Transplant Congress
Does Pretransplant C-Peptide Influence Outcomes Following Simultaneous Pancreas-Kidney Transplantation: A Case-Control Study
V. Gurram, K. Gurung, J. Rogers, A. Farney, G. Orlando, C. Jay, A. Reeves-Daniel, A. Mena-Gutierrez, N. Sakhovskaya, W. Doares, S. Kaczmorski, M. Gautreaux, R. Stratta
Abdominal Transplant Surgery, Wake Forest Baptist Health, Winston Salem, NC
*Purpose: The study purpose was to evaluate outcomes in SPKT pts according to presence or absence of pretransplant Cp*Methods: Selection criteria for Cp positive (Cp+,…
2020 American Transplant Congress
Proteomic Profiling of Circulating Extracellular Vesicles Isolated from Human Lung Transplant Recipients
S. Bansal¹, M. McGilvrey², K. Garcia-Mansfield², R. Sharma², R. Bremner¹, M. Smith¹, R. Hachem³, P. Pirrotte², T. Mohanakumar¹
¹Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ, ²Translational Genomics Research Institute (TGen), Collaborative Center for Translational Mass Spectrometry (CCTMS), Phoenix, AZ, ³Department of Medicine, Washington University School of Medicine, Phoenix, AZ
*Purpose: Circulating exosomes in human lung transplant recipients (LTxRs) with acute (AR) and chronic rejection (bronchiolitis obliterans syndrome [BOS]) contain donor human leukocyte antigen (HLA)…
2020 American Transplant Congress
Serum CXCL13 Levels Indicate Humoral Alloreactivity and Donor Specific Antibody Formation
E. S. Crichton, S. Zeng, I. Badell
Emory University, Atlanta, GA
*Purpose: Donor-specific antibodies (DSA) are an increasingly recognized cause of allograft injury, yet biomarkers to predict their development or guide their clinical management post-transplant are…
2020 American Transplant Congress
Two Novel Methods to Establish Rat Kidney Transplantation Model
M. Zheng, Z. Gui, Z. Wang, J. Wei, X. Ju, R. Tan, M. Gu
Jiangsu Province Hospital, Nanjing, China
*Purpose: Rat kidney transplantation model is a standard animal model for the anti-rejection research of kidney transplantation. However, the current methods of the model require…
2020 American Transplant Congress
Establishment of Spontaneous Tolerance of Kidney Allografts is Dependent on Mitigation of Ischemia-Reperfusion Injury via the BLTA-HVEM Pathway
Q. Yuan¹, S. Hong¹, E. Szuter¹, Y. Zhao¹, E. Acheampong¹, I. Rosales¹, M. Kronenberg², P. Russell¹, J. Madsen¹, R. Colvin¹, A. Alessandrini¹
¹Massachusetts General Hospital, Boston, MA, ²La Jolla Institute for Allergy & Immunology, La Jolla, CA
*Purpose: Kidney allografts transplanted across certain mouse strain combinations (e.g. DBA/2 to B6) develop tolerance while other combinations do not (e.g. B6 to DBA/2). We…
2020 American Transplant Congress
Follow Up of Imlifidase (IdeS) Desensitized Kidney Transplant Recipients
S. C. Jordan¹, R. A. Montgomery², T. Lundgren³, C. Legendre⁴, N. Desai⁵, G. Eckerwall⁶, L. Laxmyr⁶, H. Olsson⁶, A. Runström⁶, Å. Schiött⁶, K. Sjöholm⁶, E. Sonesson⁶, L. Winstedt⁶, T. Lorant⁷, C. Kjellman⁶
¹Cedars Sinai Medical Center, Los Angeles, CA, ²NYU Langone Health Transplant Institute, New York, NY, ³Karolinska University Hospital, Stockholm, Sweden, ⁴Hospital Necker & Paris Descartes University, Paris, France, ⁵Johns Hopkins University, Baltimore, MD, ⁶Hansa Biopharma AB, Lund, Sweden, ⁷Uppsala University, Uppsala, Sweden
*Purpose: 46 highly sensitized patients received kidney transplants after desensitization with imlifidase (currently under investigation) across four Phase 2 clinical trials, and 6-month safety and…
2020 American Transplant Congress
Basiliximab vs Antithymocyte Globulin Induction with Early Steroid Withdrawal in Kidney Transplant Recipients: Early Rejection Outcomes
A. Szczepanik¹, C. Burrelli¹, A. Bixby¹, K. Yadav², K. Chavin²
¹Pharmacy, University Hospital Cleveland Medical Center, Cleveland, OH, ²Surgery, University Hospital Cleveland Medical Center, Cleveland, OH
*Purpose: Steroid withdrawal within the first month of kidney transplant (KT) remains controversial and has demonstrated a higher risk of acute rejection. The impact of…