Am J Transplant, Volume 20, Suppl 3 Archives - Page 199 of 223 - ATC Abstracts

2020 American Transplant Congress
Pretransplant BKV-IgG Serostatus and BKV-Specific ELISPOT Assays for the Prediction of BKV Infection
H. Bae¹, J. Jang¹, H. Lee², S. Yun¹, E. Oh³
¹Department of Biomedical Science, Graduate School, Catholic University of Korea, Seoul 137-040, Korea, Republic of, ²Department of Laboratory Medicine, Catholic Kwandong University of Korea, Incheon, Korea, Republic of, ³Department of Laboratory Medicine, Catholic University of Korea, Seoul 137-040, Korea, Republic of
*Purpose: BK Polyomavirus (BK) can lead to major infectious complications and damage to the graft in kidney transplantation (KT). We investigated whether pretransplant BK serostatus…
2020 American Transplant Congress
Th17 Cell Inhibition in a Costimulation Blockade Based Regimen for Vascularized Composite Allotransplantation Using A Non-Human Primate Model
D. P. Moris, A. Atia, M. Rae, M. Song, L. Stempora, F. Leopardi, K. Williams, J. Kwun, W. Parker, A. Cardones, A. D. Kirk, L. C. Cendales
Surgery, Duke, Durham, NC
*Purpose: Vascularized composite allotransplantation (VCA) is challenged by the morbidity of non-specific immunosuppression required to prevent rejection. The use of highly specific biologics has not…
2020 American Transplant Congress
Normothermic Ex-Vivo Kidney Perfusion is Superior to Anoxic and Oxygenated Hypothermic Machine Perfusion for the Preservation of DCD Porcine Kidney Grafts
L. Mazilescu¹, M. Kaths², P. Urbanellis¹, M. Hamar³, T. Goto¹, I. Linares-Cervantes¹, Y. Noguchi¹, A. Konvalinka¹, A. Ghanekar¹, D. Bagli⁴, R. John⁵, L. Robinson⁶, M. Selzner¹
¹Multi Organ Transplant Program, Toronto General Hospital, Toronto, ON, Canada, ²Department of General, Visceral, and Transplantation Surgery, University Hospital Essen, Essen, Germany, ³Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary, ⁴Departments of Surgery(Urology)&Physiology, The Hospital for Sick Children, Toronto, ON, Canada, ⁵Laboratory Medicine & Pathobiology, Toronto General Hospital, Toronto, ON, Canada, ⁶Division of Nephrology, The Hospital for Sick Children, Toronto, ON, Canada
*Purpose: To increase the donor pool, better preservation strategies for the storage of marginal kidney grafts are crucial. Currently, kidney grafts are either stored on…
2020 American Transplant Congress
Desensitization for Deceased Donor Transplantation: Testing a New Paradigm in the Nonhuman Primate
Z. W. Fitch, R. Schmitz, P. M. Schroder, M. Manook, A. Y. Choi, J. Yoon, J. Kwun, S. J. Knechtle
Duke University, Durham, NC
*Purpose: Desensitization regimens have rarely been applied to deceased donor allotransplantation. We hypothesized that belatacept monotherapy during a simulated deceased donor waiting list period would…
2020 American Transplant Congress
Perfect Outcome of Ureteral Stenosis after Small Incision Surgical Treatment Under Magnetic Resonance Urography Localization in Kidney Transplant Patients: A Retrospective Matched Cohort Study
G. Liu, X. Wang, W. Peng, R. Wang, H. Huang, J. Wu, J. Chen
Kidney Disease Center, First Affiliated Hospital of Zhejiang University, Hangzhou, China
*Purpose: This study aimed to evaluate the outcome of ureteral stenosis after treatment with small incision open surgery under Magnetic Resonance Urography (MRU) localization in…
2020 American Transplant Congress
Evaluation of the Safety and Tolerability of Clazakizumab® as a Desensitization Agent in Highly-HLA Sensitized ESRD Patients (NCT03380962): 12m Follow-Up
A. A. Vo¹, N. Ammerman¹, E. Huang¹, M. Toyoda², S. Ge², A. Peng¹, R. Najjar¹, S. Williamson¹, C. Meyers¹, S. Sethi¹, K. Lim¹, J. Choi¹, S. C. Jordan¹
¹Kidney Transplant, Cedars Sinai Medical Ctr, Los Angeles, CA, ²Transplant Immunology Laboratory, Cedars Sinai Medical Ctr, Los Angeles, CA
*Purpose: IL-6 mediates inflammation and activation of T-cells, B-cells & plasma cells. Thus, IL-6 may represent an important target for desensitization (DES). Here we report…
2020 American Transplant Congress
The Significance of Donor Gender on Graft Survival and Histological Ischemia Reperfusion Injury in Liver Transplant Patients
T. Ito, S. Kageyama, K. J. Dery, K. Nakamura, S. M. Younan, M. M. Lu, J. DiNorcia III, V. G. Agoian, H. Yersis, D. G. Farmer, R. W. Busuttil, F. M. Kaldas
Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA
*Purpose: Experimental animal models have demonstrated improved ability of females (F) to recover from ischemia-reperfusion injury (IRI) compared with males (M). Recent work combining human…
2020 American Transplant Congress
Mycophenolic Acid Exposure in Young, Middle Age and Older Stable Renal Transplant Recipients
K. Tornatore¹, K. Attwood², R. Venuto³
¹School of Pharmacy; University at Buffalo, Williamsville Buffalo, NY, ²School of Pharmacy; University at Buffalo Department of Biostatistics; Roswell Park Comprehensive Cancer Center, Buffalo, NY, ³School of Medicine; University at Buffalo, Buffalo, NY
*Purpose: Mycophenolic acid (MPA) is an essential drug in maintenance immunosuppressive regimens. In spite of increased kidney transplants in the elderly, limited pharmacokinetic investigations comparing…
2020 American Transplant Congress
Torque Teno Virus for Risk Stratification of Graft Rejection and Infection in Kidney Transplant Recipients – A Prospective Observational Trial
K. Doberer, G. Böhmig, E. Puchhammer, G. Bond
Medical University Vienna, Vienna, Austria
*Purpose: The non-pathogenic and ubiquitous Torque Teno virus (TTV) is associated with immunosuppression in solid organ transplant recipients. This trial was designed to assess the…
2020 American Transplant Congress
Type 1 Innate Lymphoid Cells Are Critical Pro-Inflammatory Effector Cells in a Fatty Liver Mouse Model of Ischemia-Reperfusion Injury
J. Kang, K. Loh, J. Green, M. Sadat, M. Stovroff, A. Duttargi, B. Kallakury, K. Khan, T. Fishbein, A. Kroemer
MedStar Georgetown Transplant Institute, Washington, DC
*Purpose: Innate lymphoid cells (ILCs), the most recently described family of lymphoid cells, play fundamental roles in tissue homeostasis and immune regulation through the activation…