Am J Transplant, Volume 20, Suppl 3 Archives - Page 199 of 223 - ATC Abstracts

2020 American Transplant Congress
Viral Integration In BK Polyomavirus-Associated Urothelial Carcinoma in Renal-Transplant Recipients: Multistage Carcinogenesis Revealed by Next Generation Virome Capture Sequencing
Y. Wang¹, Y. Liu¹, W. Deng¹, F. Fu¹, S. Yan¹, H. Yang¹, M. Luo², R. Liu¹, J. Geng¹, J. Xu¹, Y. Wu¹, J. Ma³, J. Zhou³, N. Liu³, Y. Jin¹, R. Xia¹, N. Elias⁴, R. J. Lee⁵, A. S. Feldman⁶, M. L. Blute⁶, R. B. Colvin⁷, C. Wu⁷, Y. Miao¹
¹Department of Organ Transplantation, Nanfang Hospital, Southern Medical University, Guangzhou, China, ²State Key Laboratory of Virology, Wuhan Institute of Virology, Wuhan, China, ³Mygenostics Co., Beijing, China, ⁴Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁵Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁶Department of Urology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁷Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
*Purpose: To elucidate the mechanism of carcinogenesis by BK Polyomavirus (BKV) integration in immunocompromised patients.*Methods: Virome capture sequencing and whole genome sequencing were performed on…
2020 American Transplant Congress
Early Corticosteroid Withdrawal in Pancreas and Simultaneous Pancreas-Kidney Transplant Recipients: Long-Term Clinical and Metabolic Outcomes of from a Single Center Retrospective Cohort
A. Lichvar, L. Lin, Y. Chen, Y. Yen, D. Pierce, A. Nadeem, P. West-Thielke, I. Tang, J. Almario, M. Spaggiari, I. Tzvetanov, E. Benedetti, M. Campara
University of Illinois at Chicago, Chicago, IL
*Purpose: Tacrolimus, mycophenolate mofetil, and chronic corticosteroids (CCS) are the most popular immunosuppression regimen after pancreas transplantation. Early corticosteroid withdrawal (ECSWD) is an increasingly popular…
2020 American Transplant Congress
HLA Molecular Mismatch is an Independent Correlate of T-Cell Mediated Rejection and Potential Prognostic Biomarker in Renal Transplantation
C. Wiebe¹, D. Pochinco², I. W. Gibson³, J. Ho¹, P. Birk⁴, A. Goldberg⁴, M. Karpinski⁵, J. Shaw⁵, R. N. David⁵, P. W. Nickerson¹
¹Medicine and Immunology, University of Manitoba, Winnipeg, MB, Canada, ²Shared Health Services, Winnipeg, MB, Canada, ³Pathology, University of Manitoba, Winnipeg, MB, Canada, ⁴Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada, ⁵Medicine, University of Manitoba, Winnipeg, MB, Canada
*Purpose: HLA molecular mismatch alloimmune risk categorization has correlated with de novo donor-specific antibody (dnDSA) development, however, correlation with T-cell mediated rejection (TCMR) phenotypes is…
2020 American Transplant Congress
Plasma Cells Are Not Necessary for Regulatory B Cells and Preventing Their Differentiation Markedly Prolongs Allograft Survival
W. Yuan, Q. Ding, D. Rothstein
Thomas E Starzl Transplant Institute, University of Pittsburgh, Pittsburgh, PA
*Purpose: Plasma Cells (PCs) are the primary source of circulating antibodies. PCs were reported to be the major source of B-cell lineage IL-10, and absence…
2020 American Transplant Congress
A Pilot Study of Mkidney: A Novel Mobile Health Platform to Support OPTN Living Donor Follow-Up Data Collection
C. Sidoti¹, W. Zhang¹, M. Waldram¹, A. Thomas¹, M. Levan¹, A. Massie¹, A. Bingaman², R. Forbes³, G. Edwards³, K. Warmke³, K. Centanni³, D. Segev¹, M. Henderson¹
¹Johns Hopkins School of Medicine, Baltimore, MD, ²The Texas Transplant Institute, Methodist Specialty and Transplant Hospital, San Antonio, TX, ³Vanderbilt University Medical Center, Nashville, TN
*Purpose: Transplant hospitals struggle to meet Organ Procurement and Transplantation Network (OPTN) requirements for LKD follow-up. In the face of barriers such as cost, LKD…
2020 American Transplant Congress
Inactive Status Changes Disproportionately Impacts the Probability of Obtaining a Deceased Donor Liver Transplant in Donation Service Areas with Higher MMaT
D. Haakinson¹, S. Noreen², D. Stewart², R. Batra¹, G. Gan¹, Y. Deng¹, S. Kulkarni¹
¹Yale, New Haven, CT, ²UNOS, Richmond, VA
*Purpose: Liver transplant (LT) rate is typically calculated by including both active and inactive patients, despite the fact that inactive patients are unable to receive…
2020 American Transplant Congress
Hypothermic Oxygenated Machine Perfusion vs Static Cold Storage: Preliminary Clinical Experience from a Prospective, Multi-Center Randomized Controlled Trial
G. G. Panayotova¹, R. Quillin III², F. Paterno¹, K. Lunsford¹, M. A. McCarty¹, A. Bailey², G. Dikdan¹, J. Rosado¹, S. Shah², J. V. Guarrera¹
¹Transplant and HPB Surgery, Rutgers NJMS, Newark, NJ, ²Division of Transplantation, University of Cincinnati, Cincinnati, OH
*Purpose: Hypothermic oxygenated machine perfusion (HMP-O2) is a novel liver preservation technique currently in clinical trials. It has the potential to mitigate ischemia/reperfusion injury, as…
2020 American Transplant Congress
Largest Experience of Safety, and Efficacy of Patiromer in Solid Organ Transplants (SOT)
P. Singh¹, H. Winters², T. E. Pesavento¹, K. Schnelle²
¹Transplant Nephrology, Ohio State University, Columbus, OH, ²Transplant Pharmacy, Ohio State University, Columbus, OH
*Purpose: Hyperkalemia, a potentially life‐threatening electrolyte abnormality, is commonly seen SOT. The predisposing factors are renal-dysfunction, and medications (CNI, TMP-SMX, ACEI, and ARBs). Patiromer, a…
2020 American Transplant Congress
Novel Approaches in Targeting Chromatin Modifiers in the Induction of Transplant Tolerance
G. Wang, X. Xiao, Y. Dou, G. Kong, X. Li
Houston Methodist Research Institute, Houston, TX
*Purpose: Bromodomain and extra-terminal domain (BET) proteins are a family of proteins that function as epigenetic readers that regulate transcriptional activities of target genes. BET…
2020 American Transplant Congress
Clinicopathological Evaluation of Long-Term Survivor More Than 10 Years after Living Kidney Transplant with Corticosteroid Early Withdrawal Protocol
H. Sasaki¹, T. Tanabe¹, H. Higuchi¹, T. Tsujimoto², H. Harada¹
¹Kidney Transplant Surgery, Sapporo City General Hospital, Sapporo, Japan, ²Pharmacy, Sapporo City General Hospital, Sapporo, Japan
*Purpose: We have previously reported that favorable short-term outcomes of kidney recipients were achieved by corticosteroid early withdrawal protocol (CSEW) compared to the conventional protocol…