Am J Transplant, Volume 20, Suppl 3 Archives - Page 197 of 223 - ATC Abstracts

2020 American Transplant Congress
Letermovir Treatment for Established Cytomegalovirus Infection in Transplant Recipients
K. Linder¹, C. Kovacs², K. Mullane³, C. Wolfe⁴, N. Clark⁵, C. Butkus Small⁶, R. La Hoz⁷, J. Smith⁸, C. Kotton⁹, A. Limaye¹⁰, M. Malinis¹¹, M. Hakki¹², A. Mishkin¹³, A. Gonzalez¹⁴, D. Kaul¹
¹U Michigan, Ann Arbor, MI, ²Cleveland Clinic, Cleveland, OH, ³U Chicago, Chicago, IL, ⁴Duke, Durham, NC, ⁵Loyola, Chicago, IL, ⁶Cornell, NYC, NY, ⁷UTSW, Dallas, TX, ⁸U Wisconsin, Madison, WI, ⁹Mass General, Boston, MA, ¹⁰U Washington, Seattle, WA, ¹¹Yale, New Haven, CT, ¹²OHSU, Portland, OR, ¹³Temple, Philadelphia, PA, ¹⁴West Coast ID, Safety Harbor, FL
*Purpose: The purpose of the study was to describe the patterns of use and clinical/virologic outcomes of letermovir treatment for established CMV infection in transplant…
2020 American Transplant Congress
Outcomes of Simultaneous Pancreas-Kidney vs. Kidney Alone Transplants in Type 2 Diabetic Recipients: A Multivariate Analysis of U.S. Transplants
S. M. Riad¹, S. Jackson², D. Keys¹, V. Humphereville³, L. Caramori¹, R. Kandaswamy³
¹Medicine, University of Minnesota, Minneapolis, MN, ²Complex Care Analytics, Fairview Health Services, Minneapolis, MN, ³Surgery, University of Minnesota, Minneapolis, MN
*Purpose: The impact of simultaneous pancreas-kidney (SPK) transplants in uremic, non-obese, insulin-treated type 2 diabetic (T2DM) recipients is not well described. We analyzed the SRTR…
2020 American Transplant Congress
Evaluation of Pre-Transplant T Cell Exhaustion as a Mechanism for Immune Dysfunction and Recipient Risk of Death Following Liver Transplant
K. E. Lunsford¹, N. Aware², K. Cleveland³, D. T. Nguyen⁴, E. A. Graviss⁴, L. J. Minze³, T. N. Eagar⁴, X. C. Li³, R. M. Ghobrial³
¹Department of Surgery, Rutgers New Jersey Medical School, Newark, NJ, ²Department of Surgery, Houston Methodist Hosptial, Houston, TX, ³Department of Surgery, Houston Methodist Hospital, Houston, TX, ⁴Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX
*Purpose: Cirrhosis-related immune dysfunction likely contributes to early mortality following liver transplant (LT) resulting from infections. We previously identified a pre-transplant biomarker panel for immune…
2020 American Transplant Congress
The Mechanism How the Transplanted Islets Engraft Into White Adipose Tissue
N. Sakata, G. Yoshimatsu, T. Tanaka, R. Kawakami, S. Kodama
Department of Regenerative Medicine and Transplantation, Fukuoka University, Fukuoka, Japan
*Purpose: While islet transplantation is recognized as a promising therapeutic option for severe diabetes mellitus (DM), especially type 1 DM, it still faces to various…
2020 American Transplant Congress
Ranking Eplet Mismatches as Predictors of Graft Failure
W. Zhang¹, H. Mohammadhassanzadeh¹, K. Oualkacha², H. Gebel³, W. Klement⁴, R. Sapir-Pichhadze¹
¹McGill University, Montreal, QC, Canada, ²UQAM, Montreal, QC, Canada, ³Emory University Hospital, Atlanta, GA, ⁴Canadian Blood Services, Ottawa, ON, Canada
*Purpose: Donor:recipient matching at the level of sequence defined HLA targets (eplets) is being promoted as a biologically sound strategy to prevent graft failure. Because…
2020 American Transplant Congress
Operational Tolerance in Kidney Transplant Recipients: Tomogram Transcriptomic Study
O. Viklicky¹, J. Klema², P. Mrazova¹, D. Abramowitz³, M. Abramowicz⁴, A. Massart³, P. Hruba¹
¹Institute for Clinical and Experimental Medicine, Prague, Czech Republic, ²Czech Technical University, Prague, Czech Republic, ³Antwerp University Hospital, Antwerp, Belgium, ⁴Université Libre de Bruxelles, Brussels, Belgium
*Purpose: TOMOGRAM is a European multicenter study, that aims to identify transcriptomic and genomic signatures of operational tolerance (OT) in a recently identified cohort of…
2020 American Transplant Congress
Results of a Prospective Pilot Program for Transplantation of Patients with Alcohol-Related Liver Disease and Less Than 6 Months Abstinence
J. Quance, L. Carrique, I. Sales, L. Lilly, M. Bhat, Z. Galvin, A. Tan, S. Abbey, J. Lynch, N. Selzner
Multiorgan Transplant Institute, University of Toronto, Toronto, ON, Canada
*Purpose: In Canada, 6 months of abstinence for those with alcohol-associated liver disease (ALD) is typically required prior to being listed for liver transplantation (LT).This…
2020 American Transplant Congress
Viral Integration In BK Polyomavirus-Associated Urothelial Carcinoma in Renal-Transplant Recipients: Multistage Carcinogenesis Revealed by Next Generation Virome Capture Sequencing
Y. Wang¹, Y. Liu¹, W. Deng¹, F. Fu¹, S. Yan¹, H. Yang¹, M. Luo², R. Liu¹, J. Geng¹, J. Xu¹, Y. Wu¹, J. Ma³, J. Zhou³, N. Liu³, Y. Jin¹, R. Xia¹, N. Elias⁴, R. J. Lee⁵, A. S. Feldman⁶, M. L. Blute⁶, R. B. Colvin⁷, C. Wu⁷, Y. Miao¹
¹Department of Organ Transplantation, Nanfang Hospital, Southern Medical University, Guangzhou, China, ²State Key Laboratory of Virology, Wuhan Institute of Virology, Wuhan, China, ³Mygenostics Co., Beijing, China, ⁴Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁵Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁶Department of Urology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁷Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
*Purpose: To elucidate the mechanism of carcinogenesis by BK Polyomavirus (BKV) integration in immunocompromised patients.*Methods: Virome capture sequencing and whole genome sequencing were performed on…
2020 American Transplant Congress
Early Corticosteroid Withdrawal in Pancreas and Simultaneous Pancreas-Kidney Transplant Recipients: Long-Term Clinical and Metabolic Outcomes of from a Single Center Retrospective Cohort
A. Lichvar, L. Lin, Y. Chen, Y. Yen, D. Pierce, A. Nadeem, P. West-Thielke, I. Tang, J. Almario, M. Spaggiari, I. Tzvetanov, E. Benedetti, M. Campara
University of Illinois at Chicago, Chicago, IL
*Purpose: Tacrolimus, mycophenolate mofetil, and chronic corticosteroids (CCS) are the most popular immunosuppression regimen after pancreas transplantation. Early corticosteroid withdrawal (ECSWD) is an increasingly popular…
2020 American Transplant Congress
HLA Molecular Mismatch is an Independent Correlate of T-Cell Mediated Rejection and Potential Prognostic Biomarker in Renal Transplantation
C. Wiebe¹, D. Pochinco², I. W. Gibson³, J. Ho¹, P. Birk⁴, A. Goldberg⁴, M. Karpinski⁵, J. Shaw⁵, R. N. David⁵, P. W. Nickerson¹
¹Medicine and Immunology, University of Manitoba, Winnipeg, MB, Canada, ²Shared Health Services, Winnipeg, MB, Canada, ³Pathology, University of Manitoba, Winnipeg, MB, Canada, ⁴Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada, ⁵Medicine, University of Manitoba, Winnipeg, MB, Canada
*Purpose: HLA molecular mismatch alloimmune risk categorization has correlated with de novo donor-specific antibody (dnDSA) development, however, correlation with T-cell mediated rejection (TCMR) phenotypes is…