2020 American Transplant Congress
High Laminin Alpha 5 Expression is Observed in the Pancreas of Chronic Pancreatitis Patients and Correlates with Poor Autologous Islet Transplant Outcome
Baylor University Medical Ctr, Dallas, TX
*Purpose: During chronic pancreatitis (CP), the extracellular matrix (ECM) of the pancreas is destroyed by a vicious cycle of parenchymal autodigestion by digestive exocrine enzymes…2020 American Transplant Congress
The Role of the Molecular Microscope to Guide Therapy for T-Cell Mediated Rejection in Kidney Transplants
1Virginia Commonwealth University, Glen Allen, VA, 2ATAGC, Edmonton, AB, Canada
*Purpose: Histologic lesions (I+T) to characterize T-cell mediated rejection (TCMR) can be non-specific. In some cases the inflammation may represent a ‘response to wounding’ rather…2020 American Transplant Congress
Frailty-Inflammatory Index & Mortality after Kidney Transplantation: Development & Validation
*Purpose: Frailty is associated with poor outcomes like delirium, delayed graft function, and mortality, that may result from inflammation after kidney transplant (KT). Despite a…2020 American Transplant Congress
African American Patient Perceptions of Live Kidney Donation and Educational Health Animations
*Purpose: Disparities in pursuit of living donor kidney transplantation (LDKT) among African Americans remain challenging to overcome. Animation-based education is a promising approach to increasing…2020 American Transplant Congress
Utilization and Outcomes of Simultaneous Liver-Kidney Transplants after Change in Allocation Policy
1Surgery, Duke University Hospital, Durham, NC, 2Medicine, Duke University Hospital, Durham, NC
*Purpose: The July 10, 2017 change in simultaneous liver-kidney (SLK) listing policy imposed more stringent criteria on recipient renal function. Recipient outcomes following this change…2020 American Transplant Congress
Invasive Mould Infection in Transplant Recipients with Influenza: A 5-Year Retrospective Review
University Health Network, Toronto, ON, Canada
*Purpose: In non-transplant patients with severe influenza illness, an increased rate of invasive mould infection (IMI) has been noted possibly due to the local inflammatory…2020 American Transplant Congress
Interferon-Beta Acts Directly on T Cells to Promote Foxp3 Acetylation in Regulatory T Cells
Medicine, Icahn School of Medicine at Mount Sinai, New York, NY
*Purpose: Interferon-β (IFNβ) is a type I interferon that binds to its receptor (IFNAR) expressed on immune cells. It has known antiviral and pro-inflammatory activity…2020 American Transplant Congress
The Gut Microbiota Stimulates Dendritic Cells for Immune Modulation
University of Maryland, Baltimore, Baltimore, MD
*Purpose: The gut microbiota is a driving force in host immune regulation, and thus a potential target for intervention and drug development. We previously showed…2020 American Transplant Congress
Low-Dose Rabbit Antithymocyte Globulin Induction in Elderly Kidney Transplant Recipients at High Immunologic Risk is Safe and May Prevent Excess Rejection
1University of Colorado Hospital, Aurora, CO, 2University of Colorado School of Medicine, Aurora, CO
*Purpose: Patients aged ≥65 years are a growing segment of kidney transplant recipients (KTRs). Consensus on induction immunosuppression in this population is unclear given higher…2020 American Transplant Congress
Large Academic Center Experience with Treatment of Suspected/Confirmed Kidney Transplant Active Antibody Mediated Rejection
*Purpose: Therapeutic plasma exchange (TPE) and intravenous immunoglobulin (IVIG) are common active antibody mediated rejection (ABMR) treatments in kidney transplant recipients (KTRs), but with unclear…
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